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1.
Potential therapeutic targets from Mycobacterium abscessus (Mab): recently reported efforts towards the discovery of novel antibacterial agents to treat Mab infections.
RSC Med Chem
; 13(4): 392-404, 2022 Apr 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-35647542
2.
A new strategy for hit generation: Novel in cellulo active inhibitors of CYP121A1 from Mycobacterium tuberculosis via a combined X-ray crystallographic and phenotypic screening approach (XP screen).
Eur J Med Chem
; 230: 114105, 2022 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-35065413
3.
Tri-partite complex for axonal transport drug delivery achieves pharmacological effect.
BMC Neurosci
; 11: 8, 2010 Jan 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-20085661
4.
Fragment-based discovery of mexiletine derivatives as orally bioavailable inhibitors of urokinase-type plasminogen activator.
J Med Chem
; 51(2): 183-6, 2008 Jan 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-18163548
5.
Application of fragment screening by X-ray crystallography to beta-secretase.
J Med Chem
; 50(6): 1116-23, 2007 Mar 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-17315856
6.
Application of fragment screening by X-ray crystallography to the discovery of aminopyridines as inhibitors of beta-secretase.
J Med Chem
; 50(6): 1124-32, 2007 Mar 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-17315857
7.
Application of fragment-based lead generation to the discovery of novel, cyclic amidine beta-secretase inhibitors with nanomolar potency, cellular activity, and high ligand efficiency.
J Med Chem
; 50(24): 5912-25, 2007 Nov 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-17985862
8.
Discovery of a Potent Nonpeptidomimetic, Small-Molecule Antagonist of Cellular Inhibitor of Apoptosis Protein 1 (cIAP1) and X-Linked Inhibitor of Apoptosis Protein (XIAP).
J Med Chem
; 60(11): 4611-4625, 2017 06 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-28492317
9.
Fragment-based lead discovery using X-ray crystallography.
J Med Chem
; 48(2): 403-13, 2005 Jan 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-15658854
10.
Identification of novel p38alpha MAP kinase inhibitors using fragment-based lead generation.
J Med Chem
; 48(2): 414-26, 2005 Jan 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-15658855
11.
Fragment-based discovery of type I inhibitors of maternal embryonic leucine zipper kinase.
ACS Med Chem Lett
; 6(1): 25-30, 2015 Jan 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-25589925
12.
Structure-Based Design of Type II Inhibitors Applied to Maternal Embryonic Leucine Zipper Kinase.
ACS Med Chem Lett
; 6(1): 31-6, 2015 Jan 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-25589926
13.
Vinyl fluoride as an isoelectronic replacement for an enolate anion: inhibition of type II dehydroquinases.
Chem Commun (Camb)
; (17): 1886-7, 2002 Sep 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-12271658
14.
Potent, selective inhibitors of fibroblast growth factor receptor define fibroblast growth factor dependence in preclinical cancer models.
Mol Cancer Ther
; 10(9): 1542-52, 2011 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-21764904
15.
Fragment-based drug discovery applied to Hsp90. Discovery of two lead series with high ligand efficiency.
J Med Chem
; 53(16): 5942-55, 2010 Aug 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-20718493
16.
Discovery of (2,4-dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl]methanone (AT13387), a novel inhibitor of the molecular chaperone Hsp90 by fragment based drug design.
J Med Chem
; 53(16): 5956-69, 2010 Aug 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-20662534
17.
Selective Inhibition of Type II Dehydroquinases.
J Org Chem
; 64(8): 2612-2613, 1999 Apr 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-11674325
18.
(1R,4S,5R)-3-Fluoro-1,4,5-trihydroxy-2-cyclohexene-1-carboxylic acid: the fluoro analogue of the enolate intermediate in the reaction catalyzed by type II dehydroquinases.
Org Biomol Chem
; 2(11): 1592-6, 2004 Jun 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-15162210
19.
Enzymic synthesis of 3-[3- 13C]dehydroquinic acid.
Org Biomol Chem
; 1(19): 3271-3, 2003 Oct 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-14584789
20.
Design, synthesis and evaluation of bifunctional inhibitors of type II dehydroquinase.
Org Biomol Chem
; 1(12): 2075-83, 2003 Jun 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-12945898
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