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1.
Allergy ; 73(3): 673-682, 2018 03.
Artículo en Inglés | MEDLINE | ID: mdl-29055045

RESUMEN

BACKGROUND: Grass pollen-related seasonal allergic rhinoconjunctivitis (SARg) is clinically heterogeneous in severity, comorbidities, and response to treatment. The component-resolved diagnostics disclosed also a high heterogeneity at molecular level. Our study aimed at analyzing the characteristics of the IgE sensitization to Phleum pratense molecules and investigating the diagnostic relevance of such molecules in childhood. METHODS: We examined 1120 children (age 4-18 years) with SARg. Standardized questionnaires on atopy were acquired through informatics platform (AllergyCARD™). Skin prick tests were performed with pollen extracts. Serum IgE to airborne allergens and eight P. pratense molecules (rPhl p 1, rPhl p 2, rPhl p 4, rPhl p 5b, rPhl p 6, rPhl p 7, rPhl p 11, rPhl p 12) were tested by ImmunoCAP FEIA. RESULTS: The analysis of IgE responses against eight P. pratense molecules showed 87 profiles. According to the number of molecules recognized by IgE, the more complex profiles were characterized by higher serum total IgE, higher grass-specific serum IgE, and higher number and degree of sensitization to pollens. The most frequent IgE sensitization profile was the monomolecular Phl p 1. Sensitization to Phl p 7 was a reliable biomarker of asthma, whereas Phl p 12 of oral allergy syndrome. Sensitization to Phl p 7 was associated with a higher severity of SARg, and complex profiles were associated with longer disease duration. CONCLUSIONS: In a large pediatric population, the complexity of IgE sensitization profiles against P. pratense molecules is related to high atopic features although useless for predicting the clinical severity. The detection of serum IgE to Phl p 1, Phl p 7, and Phl p 12 can be used as clinical biomarkers of SARg and comorbidities. Further studies in different areas are required to test the impact of different IgE molecular profiles on AIT response.


Asunto(s)
Alérgenos/inmunología , Inmunoglobulina E/sangre , Phleum/inmunología , Rinitis Alérgica Estacional/diagnóstico , Rinitis Alérgica Estacional/inmunología , Adolescente , Biomarcadores/sangre , Niño , Preescolar , Estudios Transversales , Femenino , Humanos , Inmunoglobulina E/inmunología , Italia , Masculino , Proteínas Recombinantes/inmunología , Rinitis Alérgica Estacional/sangre
2.
Allergy ; 71(8): 1181-91, 2016 08.
Artículo en Inglés | MEDLINE | ID: mdl-26999633

RESUMEN

BACKGROUND: Pollen-food syndrome (PFS) is heterogeneous with regard to triggers, severity, natural history, comorbidities, and response to treatment. Our study aimed to classify different endotypes of PFS based on IgE sensitization to panallergens. METHODS: We examined 1271 Italian children (age 4-18 years) with seasonal allergic rhinoconjunctivitis (SAR). Foods triggering PFS were acquired by questionnaire. Skin prick tests were performed with commercial pollen extracts. IgE to panallergens Phl p 12 (profilin), Bet v 1 (PR-10), and Pru p 3 (nsLTP) were tested by ImmunoCAP FEIA. An unsupervised hierarchical agglomerative clustering method was applied within PFS population. RESULTS: PFS was observed in 300/1271 children (24%). Cluster analysis identified five PFS endotypes linked to panallergen IgE sensitization: (i) cosensitization to ≥2 panallergens ('multi-panallergen PFS'); (ii-iv) sensitization to either profilin, or nsLTP, or PR-10 ('mono-panallergen PFS'); (v) no sensitization to panallergens ('no-panallergen PFS'). These endotypes showed peculiar characteristics: (i) 'multi-panallergen PFS': severe disease with frequent allergic comorbidities and multiple offending foods; (ii) 'profilin PFS': oral allergy syndrome (OAS) triggered by Cucurbitaceae; (iii) 'LTP PFS': living in Southern Italy, OAS triggered by hazelnut and peanut; (iv) 'PR-10 PFS': OAS triggered by Rosaceae; and (v) 'no-panallergen PFS': mild disease and OAS triggered by kiwifruit. CONCLUSIONS: In a Mediterranean country characterized by multiple pollen exposures, PFS is a complex and frequent complication of childhood SAR, with five distinct endotypes marked by peculiar profiles of IgE sensitization to panallergens. Prospective studies in cohorts of patients with PFS are now required to test whether this novel classification may be useful for diagnostic and therapeutic purposes in the clinical practice.


Asunto(s)
Alérgenos/inmunología , Conjuntivitis Alérgica/diagnóstico , Hipersensibilidad a los Alimentos/diagnóstico , Alimentos/efectos adversos , Polen/inmunología , Rinitis Alérgica Estacional/diagnóstico , Adolescente , Edad de Inicio , Niño , Preescolar , Análisis por Conglomerados , Comorbilidad , Conjuntivitis Alérgica/epidemiología , Conjuntivitis Alérgica/inmunología , Femenino , Hipersensibilidad a los Alimentos/epidemiología , Hipersensibilidad a los Alimentos/inmunología , Humanos , Inmunoglobulina E/sangre , Inmunoglobulina E/inmunología , Italia/epidemiología , Masculino , Vigilancia de la Población , Rinitis Alérgica Estacional/epidemiología , Rinitis Alérgica Estacional/inmunología , Factores de Riesgo , Estaciones del Año , Pruebas Cutáneas , Síndrome
3.
Artículo en Inglés | MEDLINE | ID: mdl-19610263

RESUMEN

INTRODUCTION: Atopic dermatitis is a common disease in children. It is usually treated with topical steroids and/or calcineurin inhibitors in association with emollients but topical antioxidants have been recently introduced as a therapeutic option for children. The aim of this study was to evaluate the efficacy and tolerability of furfuryl palmitate, a new antioxidant molecule, in a multicenter, randomized, double-blind, vehicle-controlled study. PATIENTS AND METHODS: Children with atopic dermatitis were randomized into 2 groups treated for 2 weeks. One group of children (n = 60) was treated with a basic emollient cream and the other (n = 57) was treated with the same cream enriched with furfuryl palmitate. RESULTS: In both groups, there was a significant reduction (P < .001) in atopic dermatitis-measured using the SCORAD index-after 14 days. The reduction in the per-protocol analysis was higher for the basic cream. Treatment success was defined as a reduction of 20% or more in the SCORAD index from baseline to day 14. Patients who used treatment not permitted by the protocol were also considered treatment failures. The intention-to-treat analysis showed 70% positive results for the basic treatment and 29% for the treatment containing furfuryl palmitate (P < .0001) with a number needed to treat of 2.4 (95% confidence interval, 1.6-4.6). The emollient cream without furfuryl palmitate was observed to be more efficacious by pediatricians and parents, and no differences were reported between the 2 products in terms of tolerability. CONCLUSIONS: Both products proved to be efficacious in treating atopic dermatitis in children, but the emollient cream not containing furfuryl palmitate showed better clinical efficacy.


Asunto(s)
Dermatitis Atópica/tratamiento farmacológico , Emolientes/administración & dosificación , Furanos/administración & dosificación , Palmitatos/administración & dosificación , Administración Cutánea , Niño , Preescolar , Método Doble Ciego , Femenino , Humanos , Lactante , Masculino , Resultado del Tratamiento
4.
Panminerva Med ; 37(3): 137-41, 1995 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-8869369

RESUMEN

The etiopathogenesis of infantile autism is still unknown. Recently some authors have suggested that food peptides might be able to determine toxic effects at the level of the central nervous system by interacting with neurotransmitters. In fact a worsening of neurological symptoms has been reported in autistic patients after the consumption of milk and wheat. The aim of the present study has been to verify the efficacy of a cow's milk free diet (or other foods which gave a positive result after a skin test) in 36 autistic patients. We also looked for immunological signs of food allergy in autistic patients on a free choice diet. We noticed a marked improvement in the behavioural symptoms of patients after a period of 8 weeks on an elimination diet and we found high levels of IgA antigen specific antibodies for casein, lactalbumin and beta-lactoglobulin and IgG and IgM for casein. The levels of these antibodies were significantly higher than those of a control group which consisted of 20 healthy children. Our results lead us to hypothesise a relationship between food allergy and infantile autism as has already been suggested for other disturbances of the central nervous system.


Asunto(s)
Trastorno Autístico/etiología , Hipersensibilidad a la Leche/complicaciones , Adolescente , Animales , Especificidad de Anticuerpos , Trastorno Autístico/inmunología , Caseínas/inmunología , Niño , Femenino , Humanos , Inmunoglobulinas/análisis , Inmunoglobulinas/inmunología , Lactalbúmina/inmunología , Lactoglobulinas/inmunología , Masculino , Leche/inmunología , Hipersensibilidad a la Leche/diagnóstico , Hipersensibilidad a la Leche/dietoterapia , Pruebas Cutáneas
5.
Eur Rev Med Pharmacol Sci ; 5(2): 53-7, 2001.
Artículo en Inglés | MEDLINE | ID: mdl-11863319

RESUMEN

Allergic diseases include a variety of different illnesses (rhinitis, conjunctivitis, asthma, urticaria, dermatitis) whose physiological and pathological basis is the release of chemical mediators such as histamine, PAF (platelet activating factor), metabolites of arachidonic acid and chemotactic factors from mastocytes, basophils and eosinophils. The numerous drugs used for allergy treatment now include the new pharmacological category of cysteinyl leukotriene antagonists. The cysteinyl leukotrienes (LTC4, LTD4 and LTE4) are chemical mediators of the inflammation involved in the pathogenesis of asthma, the biological effects of which are bronchial constriction and an increase in both mucus secretion and vascular permeability. Recent studies carried out above all on adult patients suggest that antileukotrienes can play an important part not only in the acute phase but also in controlling the chronic development of bronchial asthma. Antileukotrienes have also been successfully used by some authors to control atopic dermatitis and urticaria. Though further controlled testing will be required, these applications broaden the possible range of treatments for allergic disease in all its many aspects.


Asunto(s)
Antagonistas de Leucotrieno/uso terapéutico , Adolescente , Asma/tratamiento farmacológico , Niño , Humanos , Leucotrienos/metabolismo
6.
Int J Pediatr Otorhinolaryngol ; 3(4): 287-94, 1981 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-7327846

RESUMEN

Eighty children between 4 and 14 years of age suffering from bronchial asthma were investigated. Fifty-five of them showed clinical and radiological findings of sinusitis. Of these, 13 patients with purulent postnasal drip were treated with ampicillin, phenylephrine and triprolidine (therapy A) and for the other 42 ampicillin was replaced by beclomethasone (therapy B). Thirty-four of 55 children showed improvement in sinus X-rays; 20 children had a considerable decrease in the severity of asthma and many symptoms cleared up after the therapy for sinusitis (P less than 0.001). In conclusion, owing to the high prevalence of sinusitis in children with bronchial asthma, all asthmatic children should be investigated to check for a sinus disease.


Asunto(s)
Asma/complicaciones , Sinusitis/complicaciones , Adolescente , Ampicilina/administración & dosificación , Ampicilina/uso terapéutico , Asma/tratamiento farmacológico , Beclometasona/administración & dosificación , Beclometasona/uso terapéutico , Niño , Preescolar , Femenino , Humanos , Masculino , Seno Maxilar/fisiopatología , Fenilefrina/administración & dosificación , Fenilefrina/uso terapéutico , Sinusitis/tratamiento farmacológico , Sinusitis/fisiopatología , Triprolidina/administración & dosificación , Triprolidina/uso terapéutico
7.
Minerva Gastroenterol Dietol ; 45(4): 283-5, 1999 Dec.
Artículo en Italiano | MEDLINE | ID: mdl-16498340

RESUMEN

A patient with coeliac disease presenting alopecia areas as the only symptom is described. Alopecia disappeared completely after a few months of strict gluten free diet and reappeared after an unintentional prolonged introduction of gluten. After a severe gluten free diet, a new and persistent hair growth in the alopecia areas was observed. The possibility a direct relationship in some cases, between coeliac disease and alopecia areata is confirmed.

8.
Minerva Gastroenterol Dietol ; 44(1): 1-5, 1998 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-16495876

RESUMEN

BACKGROUND: The association between diabetes mellitus and coeliac disease has been known for many years. In a random group of 175 insulin dependent diabetes mellitus patients of varying ages the following tests have been carried out: serum antigliadin antibodies (AGA) of IgA and IgG class, antireticulin antibodies (ARA) and antiendomisyum antibodies (AEA), both of IgA class. MATERIALS AND METHODS: The patients, 85 males and 90 females, had ages ranging from 1 yr to 30 yrs (102 in paediatric age--mainly between 6 and 14 years--and 73 adults). Patients with pathological values for AEA and/or ARA underwent an intestinal biopsy. RESULTS: Out of 175 patients studied, 21 had pathological values for AEA with or without pathological values for ARA and AGA, and 2 patients had only pathological values for ARA. 23 patients (21 with pathological values for AEA with or without ARA and AGA, 2 only for ARA ) underwent intestinal biopsy, all patients with pathological values for AEA had villous atrophy. The prevalence of coeliac disease among IDDM patients was 8.8% (95% CI 3.3 to 14.3) for the children and 16.4% (95% CI 7.9 to 24.9) for the adults. In patients with mucous atrophy, ARA, AGA IgA and IgG were pathological in 85%, 71% and 61% respectively. Symptoms and insulin requirements in all patients affected by coeliac disease before and after one year on a gluten free diet were also evaluated. The patients had clinical features with prevalently one or only few atypical symptoms which disappeared on a gluten free diet. Insulin requirements after one year on a gluten free diet appeared unchanged in coeliac patients. CONCLUSIONS: The need to screen all diabetic patients for coeliac disease is underlined.

9.
Pediatr Med Chir ; 26(3): 196-7, 2004.
Artículo en Inglés | MEDLINE | ID: mdl-16366404

RESUMEN

The hypothesis that certain foods or allergens might bring about convulsions has been suggested repeatedly in the literature over the last century. Some clinical studies have highlighted an unusually high prevalence of allergic disorders in patients with epilepsy. This paper reports the consistent disappearance of partial idiopathic epilepsy symptoms in a nine-year-old patient as a result of diet free of cow's milk protein. This case appears to confirm the possible role of food allergy in certain types of epilepsy in patients of pediatric age.


Asunto(s)
Epilepsias Parciales/dietoterapia , Epilepsias Parciales/inmunología , Hipersensibilidad a la Leche/complicaciones , Niño , Humanos , Inducción de Remisión
10.
Pediatr Med Chir ; 14(3): 329-33, 1992.
Artículo en Italiano | MEDLINE | ID: mdl-1528804

RESUMEN

We report the case of twins with intrahepatic cholestasis in "paucity of interlobular bile ducts". Both the children presented an associated cardiac defect even if dissimilar and a transient tubulopathy. Despite the presence of these alterations we suppose that these cases can be included among the group of rare nonsyndromic paucity of interlobular bile ducts. The different extent of the pathology in the two patients suggest a toxic etiology which could have struck more severely the twin who were less protected by the utero-placental barrier. In the literature reports we found some cases of extrahepatic biliary atresia related with maternal amphetamine addiction, but no cases of intrahepatic atresia. As during pregnancy the mother had abused of a number of drugs and in particular of amphetamine, we suppose that the amphetamine addiction can account for the hepatic pathology.


Asunto(s)
Anomalías Inducidas por Medicamentos/etiología , Conductos Biliares Intrahepáticos/anomalías , Enfermedades en Gemelos , Complicaciones del Embarazo , Trastornos Relacionados con Sustancias , Adulto , Anfetaminas/efectos adversos , Atresia Biliar/inducido químicamente , Colestasis Intrahepática/inducido químicamente , Femenino , Humanos , Recién Nacido , Masculino , Embarazo
11.
Pediatr Med Chir ; 9(6): 767-70, 1987.
Artículo en Italiano | MEDLINE | ID: mdl-3328162

RESUMEN

Group B streptococci (GBS) have gained much attention in recent years as a cause of serious infection in the newborn. Traditionally two clinical syndromes have been defined as "early onset", with fulminant septicemia, pneumonia and meningitis, and "late onset", with a mild meningitis. More recently some previously unrecognized clinical presentations of GBS disease have been documented. These include asymptomatic bacteremia, septic arthritis, osteomyelitis, ethmoiditis with orbital cellulitis, pneumoniae with empyema, conjunctivitis. The literature to date reports 30 instances of osteomyelitis due to GBS. This report describes a forty days infant with a group B streptococcal osteomyelitis of the proximal humerus. Has been also emphasized the increased frequency and the benign clinical course of streptococcal osteomyelitis in the neonate.


Asunto(s)
Artritis Infecciosa/etiología , Osteomielitis/etiología , Infecciones Estreptocócicas , Humanos , Lactante , Masculino , Streptococcus agalactiae
12.
Pediatr Med Chir ; 15(5): 531-3, 1993.
Artículo en Italiano | MEDLINE | ID: mdl-8159591

RESUMEN

The Authors describe a case of Lyme disease in a 3 year old child who lives in the center of Italy, in the Rome area. In this report it has been underlined the presence of Lyme disease also in central Italy and the importance of early diagnosis and therapy in order to prevent severe complications.


Asunto(s)
Enfermedad de Lyme/epidemiología , Preescolar , Femenino , Humanos , Italia/epidemiología , Enfermedad de Lyme/diagnóstico
13.
Minerva Pediatr ; 53(1): 43-8, 2001 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-11309542

RESUMEN

The Niikawa-Kuroki (Kabuki make-up) syndrome is a recognizable pattern of malformation consisting of mental retardation, dysmorphic cranio-facial features, bone and joint anomalies, postnatal growth deficiency and susceptibility to infections. Two male siblings, 8 and 5 years of age, displaying characteristic clinical and radiological manifestations of this syndrome as well as their father, who displays only some of the facial features, are presented.


Asunto(s)
Anomalías Múltiples/genética , Huesos/anomalías , Anomalías Craneofaciales/genética , Trastornos del Crecimiento/genética , Discapacidad Intelectual/genética , Articulaciones/anomalías , Anomalías Múltiples/diagnóstico , Adulto , Artrografía , Huesos/diagnóstico por imagen , Niño , Preescolar , Anomalías Craneofaciales/diagnóstico , Trastornos del Crecimiento/diagnóstico , Humanos , Discapacidad Intelectual/diagnóstico , Masculino , Síndrome
14.
Clin Allergy ; 9(5): 459-63, 1979 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-498488

RESUMEN

The purpose of the present study was to compare the results of the skin tests, the specific IgE levels and bronchial provocation tests in a group of sensitive asthmatic children with a Dermatophagoides pteronyssinus extract standardized by the RAST inhibition method. Skin tests showed a positive 'end point' in twelve children of 0.5 U/ml antigen; in eleven 5 U/ml; seven of 50 U/ml; six of 500 U/ml. Specific IgE was present in thirty-three children (92%). A close relationship between positive skin tests and serum IgE levels was found. Bronchial provocation tests were positive in twenty-eight children (78%): eight children with both positive RAST and positive skin tests had negative bronchial provocation tests.


Asunto(s)
Asma/inmunología , Pruebas de Provocación Bronquial , Inmunoglobulina E/inmunología , Adolescente , Alérgenos , Sitios de Unión de Anticuerpos , Bronquios/inmunología , Niño , Preescolar , Femenino , Humanos , Pruebas Intradérmicas , Masculino , Ácaros , Prueba de Radioalergoadsorción , Pruebas Cutáneas
15.
Acta Neurol Scand ; 104(6): 349-52, 2001 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-11903088

RESUMEN

OBJECTIVES: The possibility that certain foods or allergens may induce convulsions has already been reported in the literature. None of the relevant studies has, however, shown a close correlation between allergy and epilepsy, most reports being anecdotal and open to various causal hypotheses. The case-control study reported here was undertaken to test the hypothesis that epilepsy is linked to allergy. MATERIAL AND METHODS: Seventy-two epileptic children and a group of 202 controls in the same age bracket were investigated for allergy together with their immediate families. RESULTS: The study revealed significantly higher rates of eczema in the mothers and rhinitis in the siblings of the patients studied as well as generally higher incidence of allergic pathologies in both of these groups with respect to the relevant controls. A significantly higher incidence of allergy to cow's milk and asthma was also documented in the epileptic children with respect to the control group. Prick tests gave a significantly higher rate of positive results for cow's milk proteins in the cases examined with respect to the controls. The total serum IgE of a random sample of cases and controls showed no difference in mean values. CONCLUSION: The study appears to bear out the hypothesis of a higher incidence of allergy in the children with epilepsy and their immediate families than in the controls and their families.


Asunto(s)
Epilepsia/epidemiología , Hipersensibilidad a la Leche/epidemiología , Adolescente , Niño , Preescolar , Electroencefalografía , Epilepsia/diagnóstico , Femenino , Humanos , Lactante , Masculino
16.
Pediatr Allergy Immunol ; 8(2): 106-9, 1997 May.
Artículo en Inglés | MEDLINE | ID: mdl-9617782

RESUMEN

In this study we investigated the HLA association with cow milk allergy. Thirty-seven Italian children with cow milk allergy and 35 randomly selected age-matched healthy children as control group were included in the study. DNA typing was performed by restriction fragment length polymorphism (RFLP) technique. We show the first statistically significant positive association between the expression of the HLA-DQ7 antigen and cow milk allergy. Several immunological tests (skin prick test, RIA, radioallergosorbent test (RAST) and ELISA) were performed to evaluate the humoral immune responses of DQ7 positive and DQ7 negative allergic patients. Our results show that among the DQ7 positive patients the majority presented a high humoral response. Furthermore, the in vitro proliferative response of patients to the beta-lactoglobulin antigen was performed to evaluate their cell-mediated immune response. We observed that the number of the nonresponders was higher in the DQ7 positive patients when compared to the DQ7 negative patients. Our data indicate an association of HLA-DQ7 antigen with cow milk protein allergy and that the DQ7 positive patients had a prevalence of humoral rather than cellular responses.


Asunto(s)
Antígenos HLA-DQ/análisis , Hipersensibilidad a la Leche/inmunología , Adolescente , Animales , Bovinos , Niño , Preescolar , ADN/análisis , Ensayo de Inmunoadsorción Enzimática , Femenino , Predisposición Genética a la Enfermedad , Antígenos HLA-DQ/genética , Antígenos HLA-DR/análisis , Antígenos HLA-DR/genética , Humanos , Lactante , Italia , Leucocitos Mononucleares/inmunología , Masculino , Hipersensibilidad a la Leche/genética , Polimorfismo de Longitud del Fragmento de Restricción , Prueba de Radioalergoadsorción , Pruebas Cutáneas
17.
Ann Sclavo ; 18(5): 763-6, 1976.
Artículo en Italiano | MEDLINE | ID: mdl-1028390

RESUMEN

The Maunsell-test for the evaluation in vivo of a rise in blocking antibodies after specific hyposensitization therapy was perfomed in 27 children with asthma and/or graminaceous rhinitis. The Authors have found a good correlation between blocking antibodies level and clinical improvement.


Asunto(s)
Anticuerpos/aislamiento & purificación , Complejo Antígeno-Anticuerpo , Asma/inmunología , Adolescente , Formación de Anticuerpos , Asma/terapia , Niño , Desensibilización Inmunológica/métodos , Humanos , Rinitis Alérgica Estacional/inmunología , Rinitis Alérgica Estacional/terapia
18.
Minerva Pediatr ; 42(6): 215-8, 1990 Jun.
Artículo en Italiano | MEDLINE | ID: mdl-2250627

RESUMEN

Ninety-two children affected by migraine were studied, of which 49 had positive skin tests to one or more foods. Forty of those who tested positive (87%) improved after following an elimination diet for 4-6 weeks and were positive for at least one challenge test for the same types of foods which resulted in positive skin tests. Thirty-one children were cured following the elimination diet and 9 improved. At two years, despite the reintroduction of the suspected food or foods 6 to 12 months after the start of the elimination diet, these results remained unchanged.


Asunto(s)
Hipersensibilidad a los Alimentos/complicaciones , Trastornos Migrañosos/etiología , Adolescente , Niño , Preescolar , Femenino , Hipersensibilidad a los Alimentos/diagnóstico , Humanos , Inmunoglobulina E/análisis , Masculino , Pruebas Cutáneas
19.
J Pediatr ; 115(3): 380-4, 1989 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-2769496

RESUMEN

In 10 children with chronic cholestasis and without neurologic signs, we evaluated lipid peroxidation and vitamin E levels in serum and in the erythrocytes before and after a therapeutic trial with alpha-tocopherol. We also studied the effects of vitamin E administration on hematocrit and hemoglobin values and on reticulocyte and erythrocyte counts. Plasma and erythrocyte malonyldialdehyde (MDA) values were significantly higher compared with normal control values, whereas plasma and erythrocyte tocopherol measurements were lower. Oral administration of high doses of vitamin E (300 mg/day for 15 days) resulted in lower serum MDA levels, whereas serum vitamin levels did not change significantly. In erythrocytes, the MDA decreased but not to control levels, and vitamin E increased but to lower values than normal. Hematologic values also improved. We conclude that longer treatment might be necessary to completely reverse the oxidative damage associated with vitamin E deficiency in children with cholestasis.


Asunto(s)
Colestasis/sangre , Membrana Eritrocítica/metabolismo , Peroxidación de Lípido , Vitamina E/uso terapéutico , Atresia Biliar/complicaciones , Recuento de Células/efectos de los fármacos , Niño , Preescolar , Colestasis/tratamiento farmacológico , Colestasis/etiología , Enfermedad Crónica , Ácidos Grasos/metabolismo , Femenino , Hematócrito , Hemoglobinas/análisis , Humanos , Masculino , Malondialdehído/sangre , Reticulocitos , Vitamina E/sangre
20.
Dig Dis Sci ; 46(4): 831-5, 2001 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-11330420

RESUMEN

Cyclic vomiting syndrome is a disorder characterized by recurrent episodes of nausea and vomiting with complete resolution of symptoms between attacks. Nitric oxide plays a critical role in regulating several components of gastrointestinal mucosal defense and injury. Interleukin-6 has a wide variety of actions in the gastrointestinal apparatus. The purpose of this study was to evaluate the synthesis and release of nitric oxide and interleukin-6 by the esophageal and gastric mucosa in 10 children with cyclic vomiting syndrome, during symptom-free periods, and in 10 controls. The nitric oxide and interleukin-6 release by esophageal mucosa cells obtained from cyclic vomiting patients was quite similar to that in controls, but the release of nitric oxide from gastric mucosa cells of patients was significantly higher than that of controls. Conversely, no interleukin-6 was detectable in gastric mucosa cell supernatants in any of the patients. Further studies are needed to evaluate the relationship between factors triggering cyclic vomiting syndrome and the release of nitric oxide and interleukin-6 by gastric mucosa.


Asunto(s)
Esófago/metabolismo , Mucosa Gástrica/metabolismo , Interleucina-6/biosíntesis , Óxido Nítrico/biosíntesis , Vómitos/metabolismo , Células Cultivadas , Niño , Esófago/citología , Femenino , Mucosa Gástrica/citología , Humanos , Masculino , Membrana Mucosa/citología , Membrana Mucosa/metabolismo , Recurrencia , Síndrome
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