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1.
A Novel C-C Chemoattractant Cytokine (Chemokine) Receptor 6 (CCR6) Antagonist (PF-07054894) Distinguishes between Homologous Chemokine Receptors, Increases Basal Circulating CCR6+ T Cells, and Ameliorates Interleukin-23-Induced Skin Inflammation.
J Pharmacol Exp Ther
; 386(1): 80-92, 2023 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-37142443
2.
Probing the enzyme kinetics, allosteric modulation and activation of α1- and α2-subunit-containing AMP-activated protein kinase (AMPK) heterotrimeric complexes by pharmacological and physiological activators.
Biochem J
; 473(5): 581-92, 2016 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26635351
3.
Identification and optimization of indolo[2,3-c]quinoline inhibitors of IRAK4.
Bioorg Med Chem Lett
; 24(9): 2066-72, 2014 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24726805
4.
Discovery of a Series of Pyrimidine Carboxamides as Inhibitors of Vanin-1.
J Med Chem
; 65(1): 757-784, 2022 01 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-34967602
5.
Escherichia coli expression, purification and characterization of functional full-length recombinant alpha2beta2gamma3 heterotrimeric complex of human AMP-activated protein kinase.
Protein Expr Purif
; 73(2): 189-97, 2010 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-20451617
6.
Synthesis and SAR of 1,2,3,4-tetrahydroisoquinolin-1-ones as novel G-protein-coupled receptor 40 (GPR40) antagonists.
Bioorg Med Chem Lett
; 19(9): 2400-3, 2009 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19346127
7.
Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design.
J Med Chem
; 60(13): 5521-5542, 2017 07 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-28498658
8.
Structural basis for AMPK activation: natural and synthetic ligands regulate kinase activity from opposite poles by different molecular mechanisms.
Structure
; 22(8): 1161-1172, 2014 Aug 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-25066137
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