Smart Air Quality Monitoring IoT-Based Infrastructure for Industrial Environments.

Deficient air quality in industrial environments creates a number of problems that affect both the staff and the ecosystems of a particular area. To address this, periodic measurements must be taken to monitor the pollutant substances discharged into the atmosphere. However, the deployed system should also be adapted to the specific requirements of the industry. This paper presents a complete air quality monitoring infrastructure based on the IoT paradigm that is fully integrable into current industrial systems. It includes the development of two highly precise compact devices to facilitate real-time monitoring of particulate matter concentrations and polluting gases in the air. These devices are able to collect other information of interest, such as the temperature and humidity of the environment or the Global Positioning System (GPS) location of the device. Furthermore, machine learning techniques have been applied to the Big Data collected by this system. The results identify that the Gaussian Process Regression is the technique with the highest accuracy among the air quality data sets gathered by the devices. This provides our solution with, for instance, the intelligence to predict when safety levels might be surpassed.

An Automatized Contextual Marketing System Based on a Wi-Fi Indoor Positioning System.

A complete contextual marketing platform including an indoor positioning system (IPS) for smartphones is proposed and evaluated to later be deployed in large infrastructures, such as malls. To this end, we design and implement a novel methodology based on location-as-a-service (LAAS), comprising all the required phases of IPS generation: mall digital map creation, the tools/procedures for offline calibration fingerprint acquisition, the location algorithm, the smartphone app acquiring the fingerprint data, and a validation procedure. To select an appropriate fingerprint location algorithm, a comparison among K-nearest neighbors (KNN), support vector machine (SVM), and Freeloc is accomplished by employing a set of different smartphones in two malls and assessing different occupancy levels. We demonstrate that our solution can be quickly deployed at shop level accuracy in any new location, resulting in a robust and scalable proposal.

An Analytical Approach to Flow-Guided Nanocommunication Networks.

Continuous progress of nanocommunications and nano-networking is opening the door to the development of innovative yet unimaginable services, with a special focus on medical applications. Among several nano-network topologies, flow-guided nanocommunication networks have recently emerged as a promising solution to monitoring, gathering information, and data communication inside the human body. In particular, flow-guided nano-networks display a number of specific characteristics, such as the type of nodes comprising the network or the ability of a nano-node to transmit successfully, which significantly differentiates them from other types of networks, both at the nano and larger scales. This paper presents the first analytical study on the behavior of these networks, with the objective of evaluating their metrics mathematically. To this end, a theoretical framework of the flow-guided nano-networks is developed and an analytical model derived. The main results reveal that, due to frame collisions, there is an optimal number of nano-nodes for any flow-guided network, which, as a consequence, limits the maximum achievable throughput. Finally, the analytical results obtained are validated through simulations and are further discussed.

A Prototype Framework Design for Assisting the Detection of Atrial Fibrillation Using a Generic Low-Cost Biomedical Sensor.

Cardiovascular diseases are the leading cause of death around the world. As a result, low-cost biomedical sensors have been gaining importance in business and research over the last few decades. Their main benefits include their small size, light weight, portability and low power consumption. Despite these advantages, they are not generally used for clinical monitoring mainly because of their low accuracy in data acquisition. In this emerging technological context, this paper contributes by discussing a methodology to help practitioners build a prototype framework based on a low-cost commercial sensor. The resulting application consists of four modules; namely, a digitalization module whose input is an electrocardiograph signal in portable document format (PDF) or joint photographic expert group format (JPEG), a module to further process and filter the digitalized signal, a selectable data calibration module and, finally, a module implementing a classification algorithm to distinguish between individuals with normal sinus rhythms and those with atrial fibrillation. This last module employs our recently published symbolic recurrence quantification analysis (SRQA) algorithm on a time series of RR intervals. Moreover, we show that the algorithm applies to any biomedical low-cost sensor, achieving good results without requiring.

Quick and Cost-Effective Estimation of Vitamin C in Multifruit Juices using Voltammetric Methods.

Ascorbic Acid (AA) is a natural and powerful water-soluble antioxidant associated with long-lasting food products. As time passes, the AA content in products sharply decreases, and they become increasingly degraded. There are several techniques to precisely quantify AA concentrations. However, most of them employ costly laboratory instruments, such as High-Performance Liquid Chromatography (HPLC) or complex electrochemical methods, which make unfeasible recurrent AA measurements along the entire supply chain. To address this issue, we contribute with an in-field and real-time voltammetric method, carried out with a low-cost, easy-to-use, and portable device. An unmodified Screen-Printed Electrode (SPE) is used together with the device to achieve short reading times. Our method has been extensively tested in two multifruit juices using three different SPEs. Calibration curves and Limit of Detection were derived for each SPE. Furthermore, periodic experiments were conducted to study the shelf life of juices under consideration. During the analysis, a set of assays for each SPE were implemented to determine the remaining AA amount per juice and compare it with that obtained using HPLC under the same conditions. Results revealed that our cost-effective device is fully comparable to the HPLC equipment, as long as the juice does not include certain interferents; a scenario also contemplated in this article.

Machine Learning Techniques Applied to Dose Prediction in Computed Tomography Tests.

Increasingly more patients exposed to radiation from computed axial tomography (CT) will have a greater risk of developing tumors or cancer that are caused by cell mutation in the future. A minor dose level would decrease the number of these possible cases. However, this framework can result in medical specialists (radiologists) not being able to detect anomalies or lesions. This work explores a way of addressing these concerns, achieving the reduction of unnecessary radiation without compromising the diagnosis. We contribute with a novel methodology in the CT area to predict the precise radiation that a patient should be given to accomplish this goal. Specifically, from a real dataset composed of the dose data of over fifty thousand patients that have been classified into standardized protocols (skull, abdomen, thorax, pelvis, etc.), we eliminate atypical information (outliers), to later generate regression curves employing diverse well-known Machine Learning techniques. As a result, we have chosen the best analytical technique per protocol; a selection that was thoroughly carried out according to traditional dosimetry parameters to accurately quantify the dose level that the radiologist should apply in each CT test.

On the Nature of Energy-Feasible Wireless Nanosensor Networks.

Electromagnetic nanocommunications, understood as the communication between electronic nanoscale devices through electromagnetic waves in the terahertz band, has attracted increasing attention in recent years. In this regard, several solutions have already been proposed. However, many of them do not sufficiently capture the significance of the limitations in nanodevice energy-gathering and storing capacity. In this paper, we address key factors affecting the energy consumption of nanodevices, highlighting the effect of the communication scheme employed. Then, we also examine how nanodevices are powered, focusing on the main parameters governing the powering nanosystem. Different mathematical expressions are derived to analyze the impact of these parameters on its performance. Based on these expressions, the functionality of a nanogenerator is evaluated to gain insight into the conditions under which a wireless nanosensor network (WNSN) is viable from the energetic point of view. The results reveal that a micrometer-sized piezoelectric system in high-lossy environments (exceeding 100 dB/mm) becomes inoperative for transmission distances over 1.5 mm by its inability to harvest and store the amount of energy required to overcome the path loss.

A COTS-Based Portable System to Conduct Accurate Substance Concentration Measurements.

Traditionally, electrochemical procedures aimed at determining substance concentrations have required a costly and cumbersome laboratory environment. Specialized equipment and personnel obtain precise results under complex and time-consuming settings. Innovative electrochemical-based sensors are emerging to alleviate this difficulty. However, they are generally scarce, proprietary hardware and/or software, and focused only on measuring a restricted range of substances. In this paper, we propose a portable, flexible, low-cost system, built from commercial off-the-shelf components and easily controlled, using open-source software. The system is completed with a wireless module, which enables the transmission of measurements to a remote database for their later processing. A well-known PGSTAT100 Autolab device is employed to validate the effectiveness of our proposal. To this end, we select ascorbic acid as the substance under consideration, evaluating the reliability figure and obtaining the calibration curves for both platforms. The final outcomes are shown to be feasible, accurate, and repeatable.

Ionizing Radiation Measurement Solution in a Hospital Environment.

Ionizing radiation is one of the main risks affecting healthcare workers and patients worldwide. Special attention has to be paid to medical staff in the vicinity of radiological equipment or patients undergoing radioisotope procedures. To measure radiation values, traditional area meters are strategically placed in hospitals and personal dosimeters are worn by workers. However, important drawbacks inherent to these systems in terms of cost, detection precision, real time data processing, flexibility, and so on, have been detected and carefully detailed. To overcome these inconveniences, a low cost, open-source, portable radiation measurement system is proposed. The goal is to deploy devices integrating a commercial Geiger-Muller (GM) detector to capture radiation doses in real time and to wirelessly dispatch them to a remote database where the radiation values are stored. Medical staff will be able to check the accumulated doses first hand, as well as other statistics related to radiation by means of a smartphone application. Finally, the device is certified by an accredited calibration center, to later validate the entire system in a hospital environment.

Evaluating the More Suitable ISM Frequency Band for IoT-Based Smart Grids: A Quantitative Study of 915 MHz vs. 2400 MHz.

IoT has begun to be employed pervasively in industrial environments and critical infrastructures thanks to its positive impact on performance and efficiency. Among these environments, the Smart Grid (SG) excels as the perfect host for this technology, mainly due to its potential to become the motor of the rest of electrically-dependent infrastructures. To make this SG-oriented IoT cost-effective, most deployments employ unlicensed ISM bands, specifically the 2400 MHz one, due to its extended communication bandwidth in comparison with lower bands. This band has been extensively used for years by Wireless Sensor Networks (WSN) and Mobile Ad-hoc Networks (MANET), from which the IoT technologically inherits. However, this work questions and evaluates the suitability of such a "default" communication band in SG environments, compared with the 915 MHz ISM band. A comprehensive quantitative comparison of these bands has been accomplished in terms of: power consumption, average network delay, and packet reception rate. To allow such a study, a dual-band propagation model specifically designed for the SG has been derived, tested, and incorporated into the well-known TOSSIM simulator. Simulation results reveal that only in the absence of other 2400 MHz interfering devices (such as WiFi or Bluetooth) or in small networks, is the 2400 MHz band the best option. In any other case, SG-oriented IoT quantitatively perform better if operating in the 915 MHz band.

Conceptual Design of a Nano-Networking Device.

Nanotechnology is an emerging scientific area whose advances, among many others, have a positive direct impact on the miniaturization of electronics. This unique technology enables the possibility to design and build electronic components as well as complete devices (called nanomachines or nanodevices) at the nano scale. A nanodevice is expected to be an essential element able to operate in a nanonetwork, where a huge number of them would coordinate to acquire data, process the information gathered, and wirelessly transmit those data to end-points providing innovative services in many key scenarios, such as the human body or the environment. This paper is aimed at studying the feasibility of this type of device by carefully examining their main component parts, namely the nanoprocessor, nanomemory, nanoantenna, and nanogenerator. To this end, a thorough state-of-the-art review is conveyed to discuss, substantiate, and select the most suitable current technology (commercial or pre-commercial) for each component. Then, we further contribute by developing a complete conceptual nanodevice layout taking into consideration its ultra-small size (similar to a blood cell) and its very restricted capabilities (e.g., processing, memory storage, telecommunication, and energy management). The required resources as well as the power consumption are realistically estimated.

On the Feasibility of Wireless Multimedia Sensor Networks over IEEE 802.15.5 Mesh Topologies.

Wireless Multimedia Sensor Networks (WMSNs) are a special type of Wireless Sensor Network (WSN) where large amounts of multimedia data are transmitted over networks composed of low power devices. Hierarchical routing protocols typically used in WSNs for multi-path communication tend to overload nodes located within radio communication range of the data collection unit or data sink. The battery life of these nodes is therefore reduced considerably, requiring frequent battery replacement work to extend the operational life of the WSN system. In a wireless sensor network with mesh topology, any node may act as a forwarder node, thereby enabling multiple routing paths toward any other node or collection unit. In addition, mesh topologies have proven advantages, such as data transmission reliability, network robustness against node failures, and potential reduction in energy consumption. This work studies the feasibility of implementing WMSNs in mesh topologies and their limitations by means of exhaustive computer simulation experiments. To this end, a module developed for the Synchronous Energy Saving (SES) mode of the IEEE 802.15.5 mesh standard has been integrated with multimedia tools to thoroughly test video sequences encoded using H.264 in mesh networks.

An examination of the mechanisms involved in secondary clinical failure to adalimumab or etanercept in inflammatory arthropathies.

BACKGROUND: Biological therapies against tumor necrosis factor α have revolutionized the treatment of several inflammatory rheumatic diseases. However, 30% of responders will present a clinical failure after having controlled the disease for at least 6 months (secondary clinical failure). Biological therapies may induce an unwanted immune response, which may alter the bioavailability of the drug causing a loss of clinical response. OBJECTIVE: The objective of this study was to assess the correlation between secondary clinical failure (based on Disease Activity Score in 28 Joints or Bath Ankylosing Spondylitis Disease Activity Index) and the type of mechanism involved in failure (based on drug levels) in patients with inflammatory arthropathies treated with anti-tumor necrosis factor α. METHODS: Drug and antidrug antibodies (ADAs) serum levels were determined by enzyme-linked immunosorbent assay immediately before drug administration in patients with rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis who presented secondary clinical failure after at least 6 months of treatment with adalimumab (ADL) or etanercept (ETN). RESULTS: Thirty-six patients with secondary clinical failure were recruited: 63.88% had rheumatoid arthritis, 22.22% had psoriatic arthritis, and 13.88% had ankylosing spondylitis; 58.33% did not respond to ADL, whereas 41.66% did not to ETN. None of the patients treated with ETN showed either subtherapeutic drugs levels or ADAs (failure due to a primary mechanism) whereas it was found that 23.80% of the patients treated with ADL had subtherapeutic drug levels for reasons attributable to immunogenicity (failure due to a secondary mechanism; P = 0.000048). CONCLUSIONS: We suggest the utility of measuring drug and ADA levels in patients with secondary clinical failure to ADL for a better optimization and rational use, but not in patients who fail to ETN.

A comprehensive WSN-based approach to efficiently manage a Smart Grid.

The Smart Grid (SG) is conceived as the evolution of the current electrical grid representing a big leap in terms of efficiency, reliability and flexibility compared to today's electrical network. To achieve this goal, the Wireless Sensor Networks (WSNs) are considered by the scientific/engineering community to be one of the most suitable technologies to apply SG technology to due to their low-cost, collaborative and long-standing nature. However, the SG has posed significant challenges to utility operators-mainly very harsh radio propagation conditions and the lack of appropriate systems to empower WSN devices-making most of the commercial widespread solutions inadequate. In this context, and as a main contribution, we have designed a comprehensive ad-hoc WSN-based solution for the Smart Grid (SENSED-SG) that focuses on specific implementations of the MAC, the network and the application layers to attain maximum performance and to successfully deal with any arising hurdles. Our approach has been exhaustively evaluated by computer simulations and mathematical analysis, as well as validation within real test-beds deployed in controlled environments. In particular, these test-beds cover two of the main scenarios found in a SG; on one hand, an indoor electrical substation environment, implemented in a High Voltage AC/DC laboratory, and, on the other hand, an outdoor case, deployed in the Transmission and Distribution segment of a power grid. The results obtained show that SENSED-SG performs better and is more suitable for the Smart Grid than the popular ZigBee WSN approach.

Current trends in wireless mesh sensor networks: a review of competing approaches.

Finding a complete mesh-based solution for low-rate wireless personal area networks (LR-WPANs) is still an open issue. To cope with this concern, different competing approaches have emerged in the Wireless Mesh Sensor Networks (WMSNs) field in the last few years. They are usually supported by the IEEE 802.15.4 standard, the most commonly adopted LR-WPAN recommendation for point-to-point topologies. In this work, we review the most relevant and up-to-date WMSN solutions that extend the IEEE 802.15.4 standard to multi-hop mesh networks. To conduct this review, we start by identifying the most significant WMSN requirements (i.e., interoperability, robustness, scalability, mobility or energy-efficiency) that reveal the benefits and shortcomings of each proposal. Then, we re-examine thoroughly the group of proposals following different design guidelines which are usually considered by end-users and developers. Among all of the approaches reviewed, we highlight the IEEE 802.15.5 standard, a recent recommendation that, in its LR-WPAN version, fully satisfies the greatest number of WMSN requirements. As a result, IEEE 802.15.5 can be an appropriate solution for a wide-range of applications, unlike the majority of the remaining solutions reviewed, which are usually designed to solve particular problems, for instance in the home, building and industrial sectors. In this sense, a description of IEEE 802.15.5 is also included, paying special attention to its efficient energy-saving mechanisms. Finally, possible improvements of this recommendation are pointed out in order to offer hints for future research.

On maximizing the lifetime of Wireless Sensor Networks by optimally assigning energy supplies.

The extension of the network lifetime of Wireless Sensor Networks (WSN) is an important issue that has not been appropriately solved yet. This paper addresses this concern and proposes some techniques to plan an arbitrary WSN. To this end, we suggest a hierarchical network architecture, similar to realistic scenarios, where nodes with renewable energy sources (denoted as primary nodes) carry out most message delivery tasks, and nodes equipped with conventional chemical batteries (denoted as secondary nodes) are those with less communication demands. The key design issue of this network architecture is the development of a new optimization framework to calculate the optimal assignment of renewable energy supplies (primary node assignment) to maximize network lifetime, obtaining the minimum number of energy supplies and their node assignment. We also conduct a second optimization step to additionally minimize the number of packet hops between the source and the sink. In this work, we present an algorithm that approaches the results of the optimization framework, but with much faster execution speed, which is a good alternative for large-scale WSN networks. Finally, the network model, the optimization process and the designed algorithm are further evaluated and validated by means of computer simulation under realistic conditions. The results obtained are discussed comparatively.

Embedded bleeding detector into a PMMA applicator for electron intraoperative radiotherapy.

PURPOSE: The aim of this work is to present a ready to industrialize low-cost and easy-to-install bleeding detector for use in intraoperative electron radiation therapy (IOERT). The detector works in stand-alone mode and is embedded into a translucent polymethylmethacrylate (PMMA) applicator avoiding any contact with the patient, which represent a novelty compared to previous designs. The use of this detector will prevent dose misadministration during irradiation in the event of accumulation of fluids in the applicator. METHODS: The detector is based on capacitive sensor and wireless power-supply electronics. Both sensor and electronics have been embedded in the applicator, so that any contact with the patient would be avoided. Since access to the tumor can be done through different trajectories, the detector has been calibrated for different tilting angles. RESULTS: The result of the calibration provides us with a fit curve that allows the interpolation of the results at any angle. Comparison of estimated fluid height vs real height gives an error of 1 mm for tilting angles less than 10° and 2 mm for tilting angles greater than 15°. This accuracy is better than the one required by clinic. CONCLUSIONS: The performance of the bleeding detector was evaluated in situ. No interference was observed between the detector and the beam. In addition, a user-friendly mobile application has been developed to help the surgical team making decisions before and during irradiation. The measurement provided by the mobile application was stable during the irradiation process.

Relationships between heavy metal concentrations in three different body fluids and male reproductive parameters: a pilot study.

BACKGROUND: Animal studies have shown the reproductive toxicity of a number of heavy metals. Very few human observational studies have analyzed the relationship between male reproductive function and heavy metal concentrations in diverse biological fluids. METHODS: The current study assessed the associations between seminal and hormonal parameters and the concentration of the 3 most frequent heavy metal toxicants (lead, cadmium and mercury) in three different body fluids. Sixty one men attending infertility clinics that participated in a case-control study to explore the role of environmental toxins and lifestyles on male infertility were analyzed. Concentration of lead, cadmium and mercury were measured in blood and seminal plasma and whole blood using anodic stripping voltammetry and atomic absorption spectrophotometry. Serum samples were analyzed for follicle-stimulating hormone, luteinizing hormone and testosterone. Semen analyses were performed according to World Health Organization criteria. Mann-Whitney test and Spearman's rank correlations were used for unadjusted analyses. Multiple linear regression models were performed controlling for age, body mass index and number of cigarettes per day. RESULTS: There were no significant differences between cases and controls in the concentrations of heavy metals in any of the three body fluids. In multivariate analyses using all subjects no significant associations were found between serum hormone levels and metal concentrations. However there was a significant positive association between the percentage of immotile sperms and seminal plasma levels of lead and cadmium. CONCLUSIONS: Our results suggest that the presence of lead and cadmium in the reproductive tract of men may be related to a moderate alteration of their seminal parameters.

A Comprehensive approach to WSN-based ITS applications: a survey.

In order to perform sensing tasks, most current Intelligent Transportation Systems (ITS) rely on expensive sensors, which offer only limited functionality. A more recent trend consists of using Wireless Sensor Networks (WSN) for such purpose, which reduces the required investment and enables the development of new collaborative and intelligent applications that further contribute to improve both driving safety and traffic efficiency. This paper surveys the application of WSNs to such ITS scenarios, tackling the main issues that may arise when developing these systems. The paper is divided into sections which address different matters including vehicle detection and classification as well as the selection of appropriate communication protocols, network architecture, topology and some important design parameters. In addition, in line with the multiplicity of different technologies that take part in ITS, it does not consider WSNs just as stand-alone systems, but also as key components of heterogeneous systems cooperating along with other technologies employed in vehicular scenarios.

Eyes-Open Versus Eyes-Closed Somatosensory Motor Balance in Professional Soccer Players With Chronic Ankle Instability: A Case-Control Study.

BACKGROUND: Chronic ankle instability (CAI) is a condition defined by certain structural and functional deficits in the ankle joint complex after acute ankle injury. These deficits include pathological joint laxity, impaired postural control, and decreased strength and neuromuscular control. PURPOSE: To compare an eyes-open versus an eyes-closed balance training protocol in professional soccer players with CAI. STUDY DESIGN: Cohort study; Level of evidence, 2. METHODS: For this study, we evaluated 19 players from 2 professional soccer teams in Madrid, Spain, all of whom had CAI. Participants from both teams were randomly assigned to an eyes-open group (n = 9) or eyes-closed group (n = 10). All participants completed 4 weeks of a supervised exercise protocol consisting of 3 sessions per week. Members of both the eyes-open and eyes-closed groups performed the same exercise protocol in the same order of execution. At the end of the protocol, the participants were assessed for pain (visual analog scale), ankle dorsiflexion range of motion (weightbearing lunge test), dynamic stability (Star Excursion Balance Test), and fear of movement and reinjury (Tampa Scale for Kinesiophobia). We compared results both before and after balance training and between the eyes-open and eyes-closed balance training groups. RESULTS: Statistically significant differences were found for all of the assessed variables before and after balance training. No statistically significant differences were found between the eyes-closed and eyes-open groups on any variable. CONCLUSION: In the current study, eyes-closed balance training was not more effective than eyes-open balance training for CAI in professional soccer players.