Optimized ultrahigh field parallel transmission workflow using rapid presaturated TurboFLASH transmit field mapping with a three-dimensional centric single-shot readout.

PURPOSE: To evaluate the usage of three-dimensional (3D) presaturated TurboFLASH (satTFL) for B 1 + $$ {\mathrm{B}}_1^{+} $$ and B 0 $$ {\mathrm{B}}_0 $$ mapping on single channel and parallel transmission (pTx) systems. METHODS: B 1 + $$ {\mathrm{B}}_1^{+} $$ maps recorded with 3D satTFL were compared to maps from three other 3D B 1 + $$ {\mathrm{B}}_1^{+} $$ mapping sequences in an agar phantom. Furthermore, individual-channel B 1 + $$ {\mathrm{B}}_1^{+} $$ maps of 18 human subjects were recorded with 3D satTFL using B 1 + $$ {\mathrm{B}}_1^{+} $$ interferometry. A neural network was trained for masking of the maps. RESULTS: Out of the sequences compared satTFL was the only one with a mapping range exceeding well over 90°. In regions with lower flip angles there was high correspondence between satTFL and AFI. DREAM and double angle method also showed high qualitative similarity, however the magnitude differed from the other two measurements. The individual-channel B 1 + $$ {\mathrm{B}}_1^{+} $$ maps were successfully used for pTx pulse calculation in a separate study. CONCLUSION: 3D satTFL can record high-quality B 1 + $$ {\mathrm{B}}_1^{+} $$ maps with a high dynamic range in a short time. Correspondence with AFI maps is high, while measurement duration is reduced drastically.

OTUP workflow: target specific optimization of the transmit k-space trajectory for flexible universal parallel transmit RF pulse design.

PURPOSE: To optimize transmit k-space trajectories for a wide range of excitation targets and to design "universal pTx RF pulses" based on these trajectories. METHODS: Transmit k-space trajectories (stack of spirals and SPINS) were optimized to best match different excitation targets using the parameters of the analytical equations of spirals and SPINS. The performances of RF pulses designed based on optimized and non-optimized trajectories were compared. The optimized trajectories were utilized for universal pulse design. The universal pulse performances were compared with subject specific tailored pulse performances. The OTUP workflow (optimization of transmit k-space trajectories and universal pulse calculation) was tested on three test target excitation patterns. For one target (local excitation of a central area in the human brain) the pulses were tested in vivo at 9.4 T. RESULTS: The workflow produced appropriate transmit k-space trajectories for each test target. Utilization of an optimized trajectory was crucial for the pulse performance. Using unsuited trajectories diminished the performance. It was possible to create target specific universal pulses. However, not every test target is equally well suited for universal pulse design. There was no significant difference in the in vivo performance between subject specific tailored pulses and a universal pulse at 9.4 T. CONCLUSIONS: The proposed workflow further exploited and improved the universal pulse concept by combining it with gradient trajectory optimization for stack of spirals and SPINS. It emphasized the importance of a well suited trajectory for pTx RF pulse design. Universal and tailored pulses performed with a sufficient degree of similarity in simulations and a high degree of similarity in vivo. The implemented OTUP workflow and the B0 /B1+ map data from 18 subjects measured at 9.4 T are available as open source (https://github.com/ole1965/workflow_OTUP.git).

Local excitation universal parallel transmit pulses at 9.4T.

PURPOSE: To demonstrate that the concept of "universal pTx pulses" is applicable to local excitation applications. METHODS: A database of B0 / B1+ maps from eight different subjects was acquired at 9.4T. Based on these maps, universal pulses that aim at local excitation of the visual cortex area in the human brain (with a flip angle of 90° or 7°) were calculated. The remaining brain regions should not experience any excitation. The pulses were designed with an extension of the "spatial domain method." A 2D and a 3D target excitation pattern were tested, respectively. The pulse performance was examined on non-database subjects by Bloch simulations and in vivo at 9.4T using a GRE anatomical MRI and a presaturated TurboFLASH B1+ mapping sequence. RESULTS: The calculated universal pulses show excellent performance in simulations and in vivo on subjects that were not contained in the design database. The visual cortex region is excited, while the desired non-excitation areas produce the only minimal signal. In simulations, the pulses with 3D target pattern show a lack of excitation uniformity in the visual cortex region; however, in vivo, this inhomogeneity can be deemed acceptable. A reduced field of view application of the universal pulse design concept was performed successfully. CONCLUSIONS: The proposed design approach creates universal local excitation pulses for a flip angle of 7° and 90°, respectively. Providing universal pTx pulses for local excitation applications prospectively abandons the need for time-consuming subject-specific B0 / B1+ mapping and pTx-pulse calculation during the scan session.

Ultrahigh-resolution quantitative spinal cord MRI at 9.4T.

PURPOSE: To present the results of the first human spinal cord in vivo MRI scans at 9.4T. METHODS: A human brain coil was used to image the human spinal cord at 9.4T. All anatomical images were acquired with a T2 *-weighted gradient-echo sequence. A comparison of the influence of four different B0 shimming routines on the image quality was performed. Intrinsic signal-to-noise-ratio maps were determined using a pseudo-multiple replica approach. Measurements with different echo times were compared and processed to one multiecho data image combination image. Based on the multiecho acquisitions, T2 *-relaxation time maps were calculated. Algorithmic spinal cord detection and gray matter/white matter segmentation were tested. RESULTS: An echo time between 9 and 13.8 ms compromised best between gray matter/white matter contrast and image quality. A maximum in-plane resolution of 0.15 × 0.15 mm2 was achieved for anatomical images. These images offered excellent image quality and made small structures of the spinal cord visible. The scanner vendor implemented B0 shimming routine performed best during this work. Intrinsic signal-to-noise-ratio values of between 6600 and 8060 at the upper cervical spinal cord were achieved. Detection and segmentation worked reliably. An average T2 *-time of 24.88 ms ± 6.68 ms for gray matter and 19.37 ms ± 8.66 ms for white matter was calculated. CONCLUSION: The proposed human brain coil can be used to image the spinal cord. The maximum in-plane resolution in this work was higher compared with the 7T results from the literature. The 9.4T acquisitions made the small structures of the spinal cord clearly visible.