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1.
Europace ; 25(9)2023 08 02.
Artículo en Inglés | MEDLINE | ID: mdl-37649337

RESUMEN

AIMS: Pulsed field ablation (PFA) is a non-thermal ablative approach in which cardiomyocyte death is obtained through irreversible electroporation (IRE). Data correlating the biophysical characteristics of IRE and lesion characteristics are limited. The aim of this study was to assess the effect of different procedural parameters [voltage, number of cycles (NoCs), and contact] on lesion characteristics in a vegetal and animal model for IRE. METHODS AND RESULTS: Two hundred and four Russet potatoes were used. Pulsed field ablation lesions were delivered on 3 cm cored potato specimens using a multi-electrode circular catheter with its dedicated IRE generator. Different voltage (from 300 to 1200 V) and NoC (from 1 to 5×) protocols were used. The impact of 0.5 and 1 mm catheter-to-specimen distances was tested. A swine animal model was then used to validate the results observed in the vegetable model. The association between voltage, the NoCs, distance, and lesion depth was assessed through linear regression. An almost perfect linear association between lesion depth and voltage was observed (R2 = 0.95; P < 0.001). A similarly linear relationship was observed between the NoCs and the lesion depth (R2 = 0.73; P < 0.001). Compared with controls at full contact, a significant dampening on lesion depth was observed at 0.5 mm distance (1000 V 2×: 2.11 ± 0.12 vs. 0.36 ± 0.04, P < 0.001; 2.63 ± 0.10 vs. 0.43 ± 0.08, P < 0.001). No lesions were observed at 1.0 mm distance. CONCLUSION: In a vegetal and animal model for IRE assessment, PFA lesion characteristics were found to be strongly dependent on voltage settings and the NoCs, with a quasi-linear relationship. The lack of catheter contact was associated with a dampening in lesion depth.


Asunto(s)
Adiposidad , Obesidad , Animales , Porcinos , Catéteres , Electrodos , Electroporación
2.
Trop Doct ; 54(1): 16-22, 2024 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-37820369

RESUMEN

The prevalence of Helicobacter pylori (Hp) in India is approximately 64%. However, substantial regional variations necessitate high-fidelity, locality-specific studies to characterise its population distribution in India. We conducted a cross-sectional study including 2998 dyspeptic patients at a tertiary care centre in Karnataka and investigated the relationship between Hp prevalence and the Multidimensional Poverty Index (MPI) by district. Helicobacter pylori prevalence in our population was 43.2% with a significant correlation between district-specific Hp prevalence and MPI. This data can be leveraged for evaluating local Hp infection control strategies, planning interventions for Hp hotspots in Karnataka and predicting a dyspeptic patient's risk of Hp infection.


Asunto(s)
Dispepsia , Infecciones por Helicobacter , Helicobacter pylori , Humanos , Dispepsia/epidemiología , Prevalencia , Estudios Transversales , India/epidemiología , Infecciones por Helicobacter/diagnóstico , Infecciones por Helicobacter/epidemiología , Pobreza
3.
Cardiovasc Revasc Med ; 53S: S134-S138, 2023 08.
Artículo en Inglés | MEDLINE | ID: mdl-37198066

RESUMEN

The transfemoral approach for transcatheter aortic valve replacement (TAVR) is superior to alternative access strategies. Only transfemoral access has been shown to have better clinical outcomes than surgical aortic valve replacement. In our patient, severe calcification of the distal abdominal aorta posed difficulty in using transfemoral access for TAVR. We applied intravascular lithotripsy (IVL) to the distal abdominal aorta to achieve necessary luminal gain facilitating bioprosthetic aortic valve deployment.


Asunto(s)
Estenosis de la Válvula Aórtica , Calcinosis , Litotricia , Reemplazo de la Válvula Aórtica Transcatéter , Humanos , Reemplazo de la Válvula Aórtica Transcatéter/efectos adversos , Aorta Abdominal/diagnóstico por imagen , Aorta Abdominal/cirugía , Constricción Patológica/cirugía , Estenosis de la Válvula Aórtica/diagnóstico por imagen , Estenosis de la Válvula Aórtica/cirugía , Válvula Aórtica/diagnóstico por imagen , Válvula Aórtica/cirugía , Calcinosis/diagnóstico por imagen , Calcinosis/cirugía , Resultado del Tratamiento , Factores de Riesgo
4.
Cureus ; 15(9): e44522, 2023 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-37789990

RESUMEN

Duodenal perforation most commonly presents with life-threatening symptoms of acute abdomen. However, in rare cases, a perforation may have an indolent course due to subclinical progression, and the patient may present with complications at the first visit. We present a case of an anterior abdominal abscess as the initial presentation of a duodenal perforation in a 65-year-old female with no pre-morbidities. The patient presented with a painful mass in the right upper quadrant associated with fever. Physical examination revealed a tender, erythematous swelling in the right hypochondrium and lumbar regions with no signs of peritonitis. Contrast-enhanced CT (CECT) of the abdomen showed a subcapsular hepatic abscess with parietal extension, but no signs of hollow viscus perforation were visible. Empirical antibiotics were given, and incision and drainage (I&D) were performed to drain around 100 mL of pus. However, drain on postop day one demonstrated bile suggesting a hollow viscus perforation, which was confirmed by a Gastrografin study.

5.
Methodist Debakey Cardiovasc J ; 19(1): 55-60, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-37600449

RESUMEN

We report a case of recurrent ST-segment elevation myocardial infarction (STEMI) due to a previously implanted under-expanded stent with in-stent thrombosis refractory to traditional interventional techniques. We underscore the utility of bail-out shockwave intravascular lithotripsy to tackle previously under-expanded stents in this acute setting.


Asunto(s)
Litotricia , Infarto del Miocardio con Elevación del ST , Humanos , Infarto del Miocardio con Elevación del ST/diagnóstico por imagen , Infarto del Miocardio con Elevación del ST/terapia , Stents , Litotricia/efectos adversos
6.
Indian J Thorac Cardiovasc Surg ; 39(1): 60-63, 2023 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-36590053

RESUMEN

Pyopericardium is rare in the modern antibiotic era but is still infrequently seen in the setting of immunosuppression, recent thoracic surgery and sepsis. Although classically an extension of a thoracic gram-positive bacterial infection, gram-negative bacterial purulent pericarditis may be encountered in the setting of nosocomial infections. Emergent pericardial drainage allows for prompt definitive management and planning for further intervention. Early surgery should be the priority after a failed retrieval of the catheter. Appropriate surgical methods should be employed to minimize complications associated with stuck catheters. We report a case of pyopericardium secondary to a clinically silent lung abscess in an immunocompetent 49-year-old patient. This was treated by standard pericardial drainage via a pigtail catheter. Multiple failed attempts in removal warranted a surgical approach to remove the coiled catheter. The catheter was found to be coiled around the heart with presence of clots in the pericardium.

7.
Ochsner J ; 22(3): 277-280, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-36189089

RESUMEN

Background: The association between congenital spigelian hernia and ipsilateral ectopic testis has been debated in the literature, and the management of such cases has yet to be standardized. Both pediatric surgeons and sonographers should be aware of this entity to allow for prompt diagnosis and monitoring/repair because congenital spigelian hernias have a high risk of incarceration. Case Report: A 3-month-old male presented with left-sided abdominal wall swelling present since birth with coexisting left-sided undescended testis. Ultrasound confirmed the suspicion of a congenital spigelian hernia with undescended testis but failed to locate the ectopic testis. Diagnostic laparoscopy and open repair of the spigelian hernia were performed when the patient was 9 months of age. Left-sided orchidopexy was also performed as the left testis was located within the spigelian sac. The patient was asymptomatic at 1-year follow-up. Conclusion: The association between congenital spigelian hernia and ipsilateral ectopic testis requires the surgeon and sonographer to pay special attention to the spigelian hernia sac as it may contain the ectopic testis. Orchidopexy and hernia repair in very young children may be delayed while closely monitoring for incarceration to allow for improvement in immunity, an increase in size of the spermatic cord and vasculature, and avoidance of the stress of 2 separate surgeries. The surgical approach can be laparoscopic or open depending on the experience of the surgeon and the complexity of intraoperative findings.

8.
Vasc Specialist Int ; 38: 3, 2022 Mar 21.
Artículo en Inglés | MEDLINE | ID: mdl-35307697

RESUMEN

The aberrant right subclavian artery (ARSA, arteria lusoria) is the most common intrathoracic vascular anomaly, affecting up to 2% of the population. However, aneurysms of congenital anomalies are extremely unusual and often present with dysphagia, dysphonia, or dyspnea due to compression of the surrounding structures. We report a case of an asymptomatic 57-year-old male with chronic kidney disease who was incidentally found to have a large aneurysm of the ARSA on preoperative computed tomography for laparoscopic nephrectomy. Surgery is unequivocally warranted as these aneurysms are associated with a high risk of complications, including thrombosis, embolism, and rupture. We debranched the ARSA, followed by anastomosis to the right carotid artery through a right neck incision. Subsequently, aneurysmal resection was performed through left thoracotomy. The patient had an uneventful postoperative recovery and was asymptomatic during the follow-up.

9.
Proc (Bayl Univ Med Cent) ; 35(4): 552-554, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-35754597

RESUMEN

Pulmonary sequestration is a rare bronchopulmonary foregut anomaly that occurs when a portion of the lung derives its blood supply from an aberrant vessel rather than the customary tracheobronchial supply. The sequestration can be classified as intralobar or extralobar. Most patients with intralobar sequestration are asymptomatic. Among symptomatic patients, presentations vary greatly, from fever, cough with expectoration, exertional dyspnea, pleuritic chest pain, and hemoptysis to eventual lung abscess or empyema. Contrast-enhanced computed tomography/computed tomography angiography is performed to determine the origin of the anomalous blood supply as well as the pathological manifestations involving the lobes. We present a patient with diagnosed intralobar sequestration who developed pulmonary tuberculosis of the sequestered lung tissue. The patient was successfully managed with long-term antitubercular therapy and left lower lobectomy with ligation of the anomalous vessel.

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