RESUMEN
To determine whether there is an airway IFN response in infants with acute bronchiolitis and to establish whether the rate of such a response is related to the severity of illness, the expression of some IFN-induced genes was measured in nasopharyngeal washes from 39 infants with acute bronchiolitis. The results indicate that in infants with a virus-associated acute bronchiolitis there is a strong activation of IFN system and that the severity of illness is inversely related to the level of expression of IFN-induced genes. This suggests that the IFN response plays an important role in determining virus-associated respiratory disease in early life.
Asunto(s)
Bronquiolitis/genética , Regulación de la Expresión Génica , Interferones/farmacología , Bronquiolitis/fisiopatología , Bronquiolitis/virología , Citocinas/genética , Regulación de la Expresión Génica/efectos de los fármacos , Humanos , Lactante , Consumo de Oxígeno , Reacción en Cadena de la Polimerasa , Virus Sincitiales Respiratorios/aislamiento & purificación , Rhinovirus/aislamiento & purificaciónAsunto(s)
Antihipertensivos/uso terapéutico , Hernias Diafragmáticas Congénitas , Hipertensión Pulmonar/tratamiento farmacológico , Lipresina/análogos & derivados , Presión Sanguínea/efectos de los fármacos , Femenino , Humanos , Lactante , Lipresina/uso terapéutico , Oxígeno/sangre , Terlipresina , Resultado del TratamientoRESUMEN
BACKGROUND: Human bocavirus (HBoV) was first discovered in Sweden in 2005 and has now been found worldwide; however its role in clinically relevant diseases has not yet been clearly defined. OBJECTIVES: To gain new insight into HBoV infection among children hospitalized with acute respiratory infections in Rome. METHODS: Between November 2004 and May 2007, 415 nasal washings were tested for the presence of an extensive range of respiratory viruses using molecular methods. RESULTS: Viral pathogens were detected in 214 children (51.6%), 28.9% being respiratory syncytial virus (RSV) and 9.6% being rhinovirus positive. Of the 34 children (8.2%) who tested positive for HBoV, 21 (61.8%) were co-infected with another respiratory virus, mainly RSV. Human bocavirus was the only pathogen identified in four pneumonia and six bronchiolitis cases in March 2005 and January 2007, respectively. Human bocavirus was also detected in one child hospitalized with gastroenteritis and in another with erythema. CONCLUSIONS: In the examined population, HBoV was the third most common virus detected but with a high rate of co-infection with other respiratory viruses. Human bocavirus appeared to be the etiological agent in some pneumonia and bronchiolitis cases in which tests for all likely respiratory pathogens were negative.