Antagonistic activity of selenium-enriched Bifidobacterium breve against Clostridioides difficile.

Probiotics have the potential to be used in the prevention of Clostridioides difficile infection (CDI). In this study, selenium (Se)-enriched Bifidobacterium breve YH68-Se was obtained under optimal culture conditions with single-factor and response surface optimization. The overall environmental resistance of YH68-Se was superior to that of the parental strain YH68, mainly reflected in the substantial improvement of antioxidant activity and gastrointestinal tolerance. YH68-Se dramatically inhibited C. difficile growth, spore, biofilm, toxin production, and virulence gene expression, rapidly disrupted C. difficile cell membrane permeability and integrity, and altered the membrane proton motive force (PMF), induced a large outflow of intracellular substances and eventually caused bacterial death. The main factor inducing this process originated from the lactic acid (LD) in YH68-Se. In addition, the LD production of YH68 increased with increasing selenite concentration and was accompanied by enhanced activities of thioredoxin reductase (TrxR), glutathione peroxidase (GSH-Px), and increased concentration of autoinducer-2 (AI-2), which may be the crucial factors contributing to the outstanding probiotic properties of YH68-Se and their potent antagonism of C. difficile. KEY POINTS: • Compared with the parental strain B. breve YH68, the environmental resistance of YH68-Se was improved. • YH68-Se was able to produce more lactic acid, which suppressed the important physiological activities of C. difficile and rapidly disrupted their cell membrane structures. • Sodium selenite in the suitable concentration range gradually increases the yield of lactic acid and phenylacetic acid, increased the concentration of autoinducer-2, and enhanced the activities of antioxidant enzymes TrxR and GSH-Px in YH68.

An exploratory cross-sectional study on the impact of education on perception of stigma by Chinese patients with schizophrenia.

BACKGROUND: Stigma is a major issue across various society and cultures, and few studies focus on the perception of stigma by Chinese patients with schizophrenia. In the current cross-sectional study, we sought to assess the extent of internalized stigma among outpatients with schizophrenia in China and to investigate whether education level correlated with the experience of stigma. METHODS: Outpatients with schizophrenia were evaluated using the brief psychosis rating scale (BPRS), the positive and negative syndrome scale (PANSS), the clinical global impression-severity of illness (CGI-SI) scale and the Stigma Scale for Mental Illness (SSMI 2C). Patients were categorized into the high education and low education group according to their educational levels. RESULTS: One hundred thirty-three subjects were included in the study. Their mean course of illness was 4.32 ± 6.14 years (range, 1 month to 15 years). Their mean BPRS score was 19.87 ± 5.46, their mean PANSS score was 44.11 ± 13.1, and their mean CGI-SI score was 2.22 ± 0.81. In addition, the mean SSMI 2C score of the high education group (7.15 ± 0.98) was markedly higher than that of the low education group (5.75 ± 0.79, P < 0.05). The mean domain I score of the high education group (2.30 ± 0.76) was comparable to that of the low education group (2.07 ± 0.78, P > 0.05). The mean domain II score of the high education group (2.42 ± 0.96) was markedly higher than that of the low education group (2.01 ± 0.79, P < 0.05). Moreover, the mean domain III score of the high education group (2.43 ± 0.79) was significantly higher than that of the low education group (1.67 ± 0.77, P < 0.05). CONCLUSIONS: Education level impacts on the perception of stigma by patients with schizophrenia and more psycho-education should be done to improve patients' knowledge about schizophrenia.

The impact of health information echo chambers on older adults avoidance behavior: the mediating role of information fatigue and the moderating role of trait mindfulness.

Background: In the digital media era, the prevalence of algorithm-driven content push has intensified the health information echo chambers phenomenon, characterized by excessive homogenization and overload of information. This phenomenon may negatively impact the older adults, a "digitally vulnerable" group, by limiting their access to diverse health information and potentially inducing health information avoidance behaviors. However, the psychological mechanisms within this impact process remain unclear, and this study aims to explore them. Additionally, current study introduces trait mindfulness as a potential intervention tool in reducing health information avoidance behavior among the older adults. Methods: This study constructs an impact model based on the Stress-Coping Theory and the Stress-Strain-Outcome (SSO) framework. It identifies health information similarity, relevance, and overload as characteristics of the echo chamber, constituting the Stress part; information fatigue as the Strain; and health information avoidance as the Outcome, with trait mindfulness serving as a moderating factor between Strain and Outcome. A cross-sectional survey of 236 older adults individuals aged 60 and above was conducted, and the collected data were analyzed using SmartPLS and SPSS. Results: The study found that health information similarity and overload significantly increased health information fatigue among the older adults, thereby promoting avoidance behavior, but no significant correlation was found between relevance and fatigue. While there was no significant correlation between trait mindfulness and health information fatigue, it effectively moderated the avoidance behavior induced by fatigue. Conclusion: Current study reveals the impact of the health information echo chamber phenomenon on health information avoidance behavior among the older adults and the moderating role of trait mindfulness. It emphasizes the importance of breaking the health information echo chamber and promoting diverse information dissemination to improve the health information behavior of the older adults. Furthermore, the moderating role of trait mindfulness demonstrates positive intervention potential, providing the older adults with a psychological adjustment mechanism to accept and process health information with a more open attitude, thereby reducing unproductive avoidance behavior.

Effect of a closed-loop medication order executive system on safe medication administration at a tertiary hospital: a quasi-experimental study.

Background: Closed-loop electronic medication management systems are effective measures for preventing medication errors (MEs). However, there is limited evidence supporting this, and few studies have evaluated the long-term effects of these systems on safe medication. Objective: To evaluate the long-term effects of implementing a closed-loop medication order executive system on the safe clinical use of medications. Design: A quasi-experimental design. Method: Data from 2017 to 2023 were extracted and retrospectively analyzed. The primary outcome indicator was the ME rate. Secondary outcome indicators were the accuracy of order verification and patient identification and the implementation rate of fresh medicine dispensing. The autoregressive integrated moving average (ARIMA) model in time-series analysis was used to evaluate the level and trend changes in ME rates using SPSS 25.0 before and after system implementation. Root cause analysis and descriptive statistics were used to assess changes in types, stages, and causes of ME rates. The independent samples t-test was used to analyze secondary outcomes. Results: Overall, 295 MEs were reported with a mean of 0.26 ± 0.26 ME rates per month during 2017-2023. The ARIMA model showed a decrease in the average level of ME rates after system implementation, with no statistically significant decrease in the long term, and a significant drop in the ME rate in the short and medium term (p < 0.01). Nurses' administration accounted for more than 60% of errors post-implementation, and lack of communication was a prominent factor. The accuracy of order verification and patient identification and the implementation rate of fresh medicine dispensing all increased after implementation. Conclusion: Adopting a closed-loop executive system is beneficial for ensuring patient medication safety, but a single integrated system does not completely eliminate MEs. Optimizing system functionalities and applying structured handoff tools are recommended to meet clinical needs and enhance system usability.

The study used some quality management indicators to evaluate the effect of a medication order executive system on the safety of medication administration Why was the study done? Medication errors (MEs) may cause harm to patients. A medication order execution system can effectively prevent MEs, but its long-term effects have not been fully identified. What did the researchers do? The research team collected some quality management indicators at the Jiangsu Province Hospital, such as ME rates and accuracy of patient identification, from pre-implementation to post-implementation in the short, medium, and long term. What did the researchers find? The use of the system significantly reduced ME rates, especially in the short term. The accuracy and timeliness of execution of medication orders were improved. What do the findings mean? The system can ensure the safety of medication administration to a certain extent, but the prevention and control of human risks are limited. The system can still be continuously improved by optimizing the functions of the system and using tools to further reduce the occurrence of adverse events.

Fight or Flight? Curvilinear Relations between Previous Cyberbullying Victimization Experiences and Continuous Use of Social Media: Social Media Rumination and Distress as Chain Mediators.

Recently, the number of active users of social media platforms is declining, posing a challenge to the sustainability of interest in social media and related industries. Therefore, it is of great significance to examine the environmental and psychological factors that influence the continuous use of social media. Until recently, little research has examined this topic from the perspective of the relationship between previous cyberbullying victimization experiences (PCVE) and the continuous use of social media (CUOSM), not to mention the psychological mechanisms that lead to this relationship. In addition, there are paradoxes in existing studies: one side believes that PCVE causes users to become addicted to using social media, while the other side argues that PCVE drives users to escape from using social media. In order to respond to this controversy and clarify the relationship between PCVE and CUOSM, this study introduces two psychological variables, namely "social media rumination (SMR)" and "distress", in order to construct a chain mediation model. Researchers surveyed 692 people who had experienced social media cyberbullying, and analyzed the data through SPSS and Mplus. The findings were as follows: 1. There is an inverted U-shaped curve relationship between PCVE and CUOSM. Specifically, the relationship initially exhibits a positive correlation (the period named fight), which then becomes negative (the period named flight). 2. When PCVE and CUOSM are positively correlated, SMR is the main factor that contributes to an increase in CUOSM. 3. When PCVE and CUOSM are negatively correlated, distress is the major factor that causes a decline in CUOSM. This study provides an explanation for the controversy in previous research, expands the scope of social media research, and provides a practical reference for social media platforms to enhance their existing users' continuous use.

Research on the influence mechanism of privacy invasion experiences with privacy protection intentions in social media contexts: Regulatory focus as the moderator.

Introduction: In recent years, there have been numerous online privacy violation incidents caused by the leakage of personal information of social media users, yet there seems to be a tendency for users to burn out when it comes to privacy protection, which leads to more privacy invasions and forms a vicious circle. Few studies have examined the impact of social media users' privacy invasion experiences on their privacy protection intention. Protection motivation theory has often been applied to privacy protection research. However, it has been suggested that the theory could be improved by introducing individual emotional factors, and empirical research in this area is lacking. Methods: To fill these gaps, the current study constructs a moderated chain mediation model based on protection motivation theory and regulatory focus theory, and introduces privacy fatigue as an emotional variable. Results and discussion: An analysis of a sample of 4800 from China finds that: (1) Social media users' previous privacy invasion experiences can increase their privacy protection intention. This process is mediated by response costs and privacy fatigue. (2) Privacy fatigue plays a masking effect, i.e., increased privacy invasion experiences and response costs will raise individuals' privacy fatigue, and the feeling of privacy fatigue significantly reduces individuals' willingness to protect their privacy. (3) Promotion-focus individuals are less likely to experience privacy fatigue than those with prevention-focus. In summary, this trend of "lie flat" on social media users' privacy protection is caused by the key factor of "privacy fatigue", and the psychological trait of regulatory focus can be used to interfere with the development of privacy fatigue. This study extends the scope of research on privacy protection and regulatory focus theory, refines the theory of protection motivation, and expands the empirical study of privacy fatigue; the findings also inform the practical governance of social network privacy.

The effect of trait mindfulness on social media rumination: Upward social comparison as a moderated mediator.

Social media rumination means that social media users are inclined to worry about their posts, relevant situational elements, and ramifications of the posts on a regular basis, and it is one of the main reasons why people's use of social media is linked to unfavorable mental health and interpersonal results. Rumination is antagonistic to mindfulness, which entails paying attention on purpose and without judgment, and mindfulness appears to be useful in reducing rumination. However, in the context of social media, the nature of the relationship between rumination and mindfulness has gained less attention. The current research study indicates that trait mindfulness, upward social comparison (USC), and self-esteem are implicated in social media rumination (SMR). However, no research study has synthesized the findings into one model. Therefore, the current research study aims to explore the relationship between trait mindfulness and SMR, the mediating effect of USC, and the moderating effect of self-esteem. The model was tested using AMOS and the PROCESS macro in SPSS with bootstrapping. According to the findings, SC appears to have a moderated mediator effect on the relationship between trait mindfulness and SMR. Specifically, individuals with high mindfulness trait do not necessarily have less USC. Self-esteem moderated the above mediation. The beneficial effect of trait mindfulness on social media rumination is explained in depth in this study.

A cross-sectional study on perception of stigma by Chinese schizophrenia patients.

OBJECTIVE: In this cross-sectional study, we sought to assess the extent of internalized stigma among inpatients and outpatients with schizophrenia in the People's Republic of China and to investigate whether education level correlated with the experience of stigma. METHODS: Schizophrenia patients were evaluated using the Brief Psychiatric Rating Scale (BPRS), the Positive and Negative Syndrome Scale (PANSS), the Clinical Global Impressions-Severity of Illness (CGI-S) scale and the Stigma Scale for Mental Illness (SSMI-C). Patients were categorized into high education and low education groups, according to their educational levels. RESULTS: One hundred thirty-three subjects were included in the study. Their mean course of illness was 4.32±6.14 years (range: 1 month to 15 years). Their mean BPRS score was 19.87±5.46, their mean PANSS score was 44.11±13.1, and their mean CGI-S score was 2.22±0.81. In addition, their mean SSMI-C score was 6.49±0.9. The mean SSMI-C score of patients who have received high school education or above was 7.15±0.98, which was markedly higher than that of patients who have received middle school education or below, which was 5.75±0.79 (P<0.05). Before the study most patients (92.5%, 123/133) took atypical drugs. CONCLUSION: Education level impacts on the perception of stigma by schizophrenia patients, and more psychoeducation should be undertaken to improve patients' knowledge about schizophrenia.