[The outcomes of Tiantan first-aid protocol on critically ill patients with primary central nervous system lymphoma].

Objective: To examine the outcomes of Tiantan first-aid protocol on critically ill patients with primary central nervous system lymphoma (PCNSL). Methods: The clinical data of 18 patients with PCNSL who were treated according to Tiantan first-aid protocol at Department of Neurosurgery,Beijing Tiantan Hospital, Capital Medical University from November 2019 to December 2021 were retrospectively analyzed. There were 9 males and 9 females, aged (56.9±11.1)years (range: 29 to 77 years). The median Karnofsky performance status(KPS) score at admission was 40 (range: 20 to 60). Three patients were mild coma, 3 were lethargy and 12 were conscious. The mean midline shift was 0.7 cm (range: 0 to 1.8 cm). After admission, all patients were treated according to the plan of rapid biopsy, rapid routine pathology and rapid salvage chemotherapy. The treatment procedures, clinical and radiographic outcomes, KPS score and adverse reactions of patients after chemotherapy were collected. Results: All of the 18 patients completed the first-aid treatment. The median duration from admission to the biopsy was 1 day (range: 0 to 5 days), from biopsy to routine pathological diagnosis was 1 day (range: 1 to 4 days) and from routine pathology to salvage chemotherapy was 1 day (range: 0 to 4 days). All the patients were pathologically confirmed with diffuse large B cell lymphoma, 1 patient was double-hit lymphoma. Seventeen patients underwent clinical remission and 1 died of cardiac dysfunction. The successful salvage rate was 17/18. Radiologically, complete remission was observed in 1 case, partial remission in 16 cases, and stable disease in 1 case. The median KPS score at discharge was 60 (range: 30 to 80). The mild gastrointestinal, hematological and hepatic adverse effects were observed after chemotherapy. Conclusion: Tiantan first-aid protocol is effective for critically ill patients with PCNSL, which has the merit to be popularly used and improved.

In-fiber Mach-Zehnder interferometer with piecewise interference spectrum based on hole-assisted dual-core fiber for refractive index sensing.

We demonstrate theoretically and experimentally a novel in-fiber Mach-Zehnder interferometer (MZI) with piecewise interference spectrum. The interferometer is constructed by splicing a short section of single eccentric hole-assisted dual-core fiber (SEHADCF) to two single mode fibers (SMFs) with a lateral-offset. Due to the offset splicing and the small distance between cores, different core modes in two cores of the SEHADCF can be excited to form interference at the different wavelength ranges. The discontinuous region of the interference spectrum can be employed as a mark to identify the order of the interference valley. The in-fiber MZI is experimentally investigated as a refractive index sensor, the sensitivity of 353.9 nm/RIU is obtained in the RI range of 1.335 ~1.395. The in-fiber MZI with a high sensitivity has a great potential in biological and chemical applications. Especially, due to the ability to identify the order of interference valleys by the discontinuous region, the proposed in-fiber MZI can improve the reliability of fiber sensors in remote monitoring applications.

In-fiber Mach-Zehnder interferometer with piecewise interference spectrum based on hole-assisted dual-core fiber for refractive index sensing: erratum.

This erratum is presented to correct Fig. 3 in [Opt. Express26(15), 19091 (2018)].

Optically controlled background-free terahertz switching in chiral metamaterial.

We demonstrate a multiband background-free terahertz (THz) switch in photoactive chiral metamaterial using polarization conversion. Orthogonal arrangement of two asymmetrical split-ring apertures allows a high polarization conversion efficiency and low copolarization transmission. The chiral metamaterial embedded with photoactive silicon promises a dynamic control on cross-polarization transmission and thus enables an efficient background-free THz switch. The on/off state of THz metamaterial switching can be efficiently controlled by an optical pump. The realization of a cross-polarization THz switch provides a new mechanism of mode switching to control THz wave propagation and will be a promising candidate for polarization devices.

[Studies on clinicopathological features of duodenal-type follicular lymphoma of 18 patients].

To investigate the clinical and pathological characteristics of duodenal-type follicular lymphoma (D-FL), and to deepen the understanding of Duodenal-type follicular lymphoma. The clinical symptoms, endoscopic features, pathologic features, immunophenotype, molecular pathological features and treatment follow-up of 18 D-FL patients diagnosed in Department of Pathology, Beijing Tiantan Hospital affiliated to Capital Medical University between January 2020 and July 2023 were summarized. A total of 18 patients with D-FL were included, including 10 males and 8 females. The median age was 49 (32-69) years respectively. Most of the patients were found during gastroenteroscopy or presented with the common gastrointestinal symptoms of stomach pain, acid reflux, vomiting and diarrhea. Most endoscopic findings were multiple small gray and white polyposis. In the pathological morphology, the mucous layer and submucous layer showed lymphoid follicular structures with full and strained follicles. The immunophenotype showed that the tumor cells strongly expressed CD20 and BCL2 and had low proliferation activity. Immunoglobulin clonal analysis of 1 case showed IgK monoclonal rearrangement (1/1). FISH showed 1 case of BCL2 gene rearrangement (1/3). All patients did not receive targeted chemotherapy and adopted a wait-and-see strategy. Median follow-up was 12 (2-34) months. This study shows that D-FL is an indolent lymphoma, which tends to occur in the duodenum and has a good prognosis.

Coherent control of double deflected anomalous modes in ultrathin trapezoid-shaped slit metasurface.

Coherent light-matter interaction in ultrathin metamaterials has been demonstrated to dynamically modulate intensity, polarization and propagation direction of light. The gradient metasurface with a transverse phase variation usually exhibits an anomalous refracted beam of light dictated by so-called generalized Snell's law. However, less attention has been paid to coherent control of the metasurface with multiple anomalous refracted beams. Here we propose an ultrathin gradient metasurface with single trapezoid-shaped slot antenna as its building block that allows one normal and two deflected transmitted beams. It is numerically demonstrated that such metasurface with multiple scattering modes can be coherently controlled to modulate output intensities by changing the relative phase difference between two counterpropagating coherent beams. Each mode can be coherently switched on/off and two deflected anomalous beams can be synchronously dictated by the phase difference. The coherent control effect in the trapezoid-shaped slit metasurface will offer a promising opportunity for multichannel signals modulation, multichannel sensing and wave front shaping.

Hybrid metamaterial switching for manipulating chirality based on VO2 phase transition.

Polarization manipulations of electromagnetic waves can be obtained by chiral and anisotropic metamaterials routinely, but the dynamic and high-efficiency modulations of chiral properties still remain challenging at the terahertz range. Here, we theoretically demonstrate a new scheme for realizing thermal-controlled chirality using a hybrid terahertz metamaterial with embedded vanadium dioxide (VO2) films. The phase transition of VO2 films in 90° twisted E-shaped resonators enables high-efficiency thermal modulation of linear polarization conversion. The asymmetric transmission of linearly polarized wave and circular dichroism simultaneously exhibit a pronounced switching effect dictated by temperature-controlled conductivity of VO2 inclusions. The proposed hybrid metamaterial design opens exciting possibilities to achieve dynamic modulation of terahertz waves and further develop tunable terahertz polarization devices.

Dual-polarity metamaterial circular polarizer based on giant extrinsic chirality.

Chirality is ubiquitous in nature. The associated optical activity has received much attention due to important applications in spectroscopy, analytical chemistry, crystallography and optics, however, artificial chiral optical materials are complex and difficult to fabricate, especially in the optical range. Here, we propose an ultrathin dual-polarity metamaterial circular polarizer by exploiting the mechanism of giant extrinsic chirality. The polarity of the circular polarizer with large suppression of linear anisotropy can be switched by changing the sign of incident angle. The microwave experiments and optical simulations demonstrate that the large angle of incidence facilitates the high-efficiency circular polarizer, which can be realized in the whole spectra from microwave to visible frequencies. The ultrathin single-layer metamaterials with extrinsic chirality will be a promising candidate for circular polarization devices.

[Construction of linkage map and mapping resistance gene of Scterotinia scterotiorum in Brassica napus].

Scterotinia scterotiorum (Lib.) de by is a world-wide disease, which seriously decreases the yield and the quality of oil of rapeseed. Mapping resistance genes of S. scterotiorum is of vital effect to breed new elite cultivars resisting the disease. In this paper, we reported that a RAPD linkage map was constructed, including 193 RAPD markers, 19 linkage groups and covering 1,324 cM, by using Mapmaker 3.0. On the basis of map, and resistance genes, Sc1, Sc2 and Sc3, were located in 4th, 8th and 18th linkage groups. Among three QTLs, Sc2 has the characteristics of major gene with explained 29%. The three QTLs together explained about 56% of phenotypic variation.

A novel Bacillus thuringiensis strain LLB6, isolated from bryophytes, and its new cry2Ac-type gene.

AIMS: To isolate and characterize the novel Bacillus thuringiensis strains from bryophytes collected from Wuyi Mountain, Fujian Province of China, and identify new B. thuringiensis strains and toxins active against mosquitoes. METHODS AND RESULTS: Twelve novel B. thuringiensis strains were isolated from 76 bryophyte samples. According to the results of this preliminary screening, LLB6 was the most toxic to Aedes albopictus. Then phase-contrast as well as scanning electron microscopy, bioassays, cloning, sequencing and expression were performed to characterize the novel isolate LLB6 and its new gene cry2Ac5. CONCLUSIONS: Bacillus thuringiensis occurred naturally on bryophytes. LLB6 isolated from Physcomitrium japonicum was toxic to A. albopictus. A new cry2Ac5 gene of LLB6 was detected, cloned and expressed successfully. Bioassays on A. albopictus showed that the expressed Cry2Ac5 was also toxic to the third instar larvae. SIGNIFICANCE AND IMPACT OF THE STUDY: This is the first report of B. thuringiensis strains isolated from bryophytes. It represents a specific source of new B. thuringiensis strains and is of great importance for the knowledge of the ecology of B. thuringiensis. Novel LLB6 harboring the new gene cry2Ac5 and its expressed Cry2Ac5 protein revealed activity against A. albopictus and became a new member of B. thuringiensis toxins.