RESUMEN
BACKGROUND: The signals acquired in brain-computer interface (BCI) experiments usually involve several complicated sampling, artifact and noise conditions. This mandated the use of several strategies as preprocessing to allow the extraction of meaningful components of the measured signals to be passed along to further processing steps. In spite of the success present preprocessing methods have to improve the reliability of BCI, there is still room for further improvement to boost the performance even more. METHODS: A new preprocessing method for denoising P300-based brain-computer interface data that allows better performance with lower number of channels and blocks is presented. The new denoising technique is based on a modified version of the spectral subtraction denoising and works on each temporal signal channel independently thus offering seamless integration with existing preprocessing and allowing low channel counts to be used. RESULTS: The new method is verified using experimental data and compared to the classification results of the same data without denoising and with denoising using present wavelet shrinkage based technique. Enhanced performance in different experiments as quantitatively assessed using classification block accuracy as well as bit rate estimates was confirmed. CONCLUSION: The new preprocessing method based on spectral subtraction denoising offer superior performance to existing methods and has potential for practical utility as a new standard preprocessing block in BCI signal processing.