1.
Chem Commun (Camb)
; (10): 1261-3, 2005 Mar 14.
Artículo
en Inglés
| MEDLINE
| ID: mdl-15742045
RESUMEN
A neutral uridine-based amphiphile is described which condenses plasmid DNA. AFM studies show that the three distinct structural components of the amphiphile (i.e, nucleobase, alkyl chains, and poly(ethylene glycol)) are required for the formation of DNA-amphiphile supramolecular assemblies on a mica surface.
Asunto(s)
ADN/química , Tensoactivos/química , Uridina/química , Sustancias Macromoleculares/química , Microscopía de Fuerza Atómica/métodos , Conformación Molecular , Polietilenglicoles/química , Sensibilidad y Especificidad , Solubilidad , Propiedades de Superficie
2.
Org Lett
; 4(26): 4571-4, 2002 Dec 26.
Artículo
en Inglés
| MEDLINE
| ID: mdl-12489932
RESUMEN
[reaction: see text] A facile procedure for the incorporation of N-methyl phenothiazine as the terminal nucleoside in oligodeoxynucleotides is reported. The phenothiazine nucleoside analogue is synthesized and then incorporated into DNA using an automated DNA solid-phase synthesizer. Phenothiazine-labeled oligodeoxynucleotides form stable B-form duplexes with higher melting temperatures compared to unlabeled DNA duplexes.