Detalles de la búsqueda
1.
ICH M9 Guideline in Development on Biopharmaceutics Classification System-Based Biowaivers: An Industrial Perspective from the IQ Consortium.
Mol Pharm
; 17(2): 361-372, 2020 02 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-31846335
2.
Simultaneous Physiologically Based Pharmacokinetic (PBPK) Modeling of Parent and Active Metabolites to Investigate Complex CYP3A4 Drug-Drug Interaction Potential: A Case Example of Midostaurin.
Drug Metab Dispos
; 46(2): 109-121, 2018 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-29117990
3.
A hybrid wavelet de-noising and Rank-Set Pair Analysis approach for forecasting hydro-meteorological time series.
Environ Res
; 160: 269-281, 2018 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29032311
4.
Verification of a physiologically based pharmacokinetic model of ritonavir to estimate drug-drug interaction potential of CYP3A4 substrates.
Biopharm Drug Dispos
; 39(3): 152-163, 2018 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-29451681
5.
Pharmacokinetics, Distribution, Metabolism, and Excretion of Omadacycline following a Single Intravenous or Oral Dose of 14C-Omadacycline in Rats.
Antimicrob Agents Chemother
; 61(1)2017 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27821446
6.
Midostaurin, a Novel Protein Kinase Inhibitor for the Treatment of Acute Myelogenous Leukemia: Insights from Human Absorption, Metabolism, and Excretion Studies of a BDDCS II Drug.
Drug Metab Dispos
; 45(5): 540-555, 2017 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-28270565
7.
Physiologically Based Pharmacokinetic Model Predictions of Panobinostat (LBH589) as a Victim and Perpetrator of Drug-Drug Interactions.
Drug Metab Dispos
; 45(12): 1304-1316, 2017 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-28912253
8.
Integrated TK-TD modeling for drug-induced concurrent tachycardia and QT changes in beagle dogs.
J Pharmacokinet Pharmacodyn
; 44(5): 449-462, 2017 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-28643108
9.
Utilization of Stable Isotope Labeling to Facilitate the Identification of Polar Metabolites of KAF156, an Antimalarial Agent.
Drug Metab Dispos
; 44(10): 1697-708, 2016 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-27486238
10.
Identification of Three Novel Ring Expansion Metabolites of KAE609, a New Spiroindolone Agent for the Treatment of Malaria, in Rats, Dogs, and Humans.
Drug Metab Dispos
; 44(5): 653-64, 2016 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-26921386
11.
Application of physiologically based absorption modeling to formulation development of a low solubility, low permeability weak base: mechanistic investigation of food effect.
AAPS PharmSciTech
; 15(2): 400-6, 2014 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-24435225
12.
Utility of physiologically based modeling and preclinical in vitro/in vivo data to mitigate positive food effect in a BCS class 2 compound.
AAPS PharmSciTech
; 14(3): 1255-66, 2013 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-23955148
13.
Human Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ASC42, a Novel Farnesoid X Receptor Agonist.
Drugs R D
; 23(4): 453-464, 2023 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-37919483
14.
An adenosine nucleoside inhibitor of dengue virus.
Proc Natl Acad Sci U S A
; 106(48): 20435-9, 2009 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19918064
15.
Nilotinib preclinical pharmacokinetics and practical application toward clinical projections of oral absorption and systemic availability.
Biopharm Drug Dispos
; 33(9): 536-49, 2012 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-23097199
16.
Inhibition of dengue virus RNA synthesis by an adenosine nucleoside.
Antimicrob Agents Chemother
; 54(7): 2932-9, 2010 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-20457821
17.
Model-Informed Drug Development for Everolimus Dosing Selection in Pediatric Infant Patients.
CPT Pharmacometrics Syst Pharmacol
; 9(4): 230-237, 2020 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-32150661
18.
Ribociclib Drug-Drug Interactions: Clinical Evaluations and Physiologically-Based Pharmacokinetic Modeling to Guide Drug Labeling.
Clin Pharmacol Ther
; 108(3): 575-585, 2020 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-32557601
19.
IMI - Oral biopharmaceutics tools project - Evaluation of bottom-up PBPK prediction success part 4: Prediction accuracy and software comparisons with improved data and modelling strategies.
Eur J Pharm Biopharm
; 156: 50-63, 2020 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-32805361
20.
Disposition of vildagliptin, a novel dipeptidyl peptidase 4 inhibitor, in rats and dogs.
Drug Metab Dispos
; 37(3): 545-54, 2009 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-19074976