A mild hand cleanser, alkyl ether sulphate supplemented with alkyl ether carboxylic acid and alkyl glucoside, improves eczema on the hand and prevents the growth of Staphylococcus aureus on the skin surface.

OBJECTIVE: Washing the hands using cleansers with antiseptic materials is the most popular method for hand hygiene and helps maintain health by preventing food poisoning and bacterial infections. However, repeated hand washing tends to induce eczema of the hand, such as dryness, cracking and erythema. Moreover, eczema on the hand leads to increased levels in Staphylococcus aureus (S. aureus) on the skin surface in contrast to expectations. Thus, mild hand cleansers which induce less eczema even with repeated washings are desired. Here, we evaluated the efficacy of a hand cleanser formulated with alkyl ether sulphate (AES), alkyl ether carboxylic acid (AEC) and alkyl glucoside (AG) that contains isopropyl methylphenol (IPMP) on skin symptoms and S. aureus levels. METHODS: Eczema of the hand and the presence of S. aureus on the skin surface were analysed prior to and following 4 weeks of usage of the hand cleanser. A soap-based hand cleanser with IPMP was used as a reference cleanser. Eczema and cutaneous conditions were evaluated by visual grading, transepidermal water loss (TEWL), stratum corneum moisture-retention ability (MRA) and skin surface pH. RESULTS: The repeated use of the soap-based hand cleanser significantly worsened the hand dryness, scaling and cracks on the tips of the fingers and significantly increased the TEWL and decreased the MRA. In contrast, usage of the test cleanser only induced a significant increase in skin dryness but did not induce skin scaling or cracking and did not increase TEWL or decrease the MRA. Corresponding to these changes in skin symptoms, the presence of S. aureus increased the following use of the reference cleanser but not the test cleanser. There was no significant difference in skin surface pH between the two cleansers. Moreover, the increase in S. aureus was significantly correlated to the worsening of skin dryness and scaling. CONCLUSION: These results suggest that not only antimicrobial activity but also the mildness, which minimizes cutaneous effects, are important for hand cleansers to prevent the growth of S. aureus. The cleanser formulated with AES, AEC and AG containing IPMP is mild and is effective to promote hand hygiene.

On atmospheric loss of oxygen ions from earth through magnetospheric processes.

In Earth's environment, the observed polar outflow rate for O(+) ions, the main source of oxygen above gravitational escape energy, corresponds to the loss of approximately 18% of the present-day atmospheric oxygen over 3 billion years. However, part of this apparent loss can actually be returned to the atmosphere. Examining loss rates of four escape routes with high-altitude spacecraft observations, we show that the total oxygen loss rate inferred from current knowledge is about one order of magnitude smaller than the polar O(+) outflow rate. This disagreement suggests that there may be a substantial return flux from the magnetosphere to the low-latitude ionosphere. Then the net oxygen loss over 3 billion years drops to approximately 2% of the current atmospheric oxygen content.

A cascade associative memory model with a hierarchical memory structure.

The introduction of a hierarchical memory structure into a cascade associative memory model for storing hierarchically correlated patterns improves the storage capacity and the size of the basins of attraction remarkably. A learning algorithm groups descendants (second-level patterns) according to their ancestors (first-level ones), and organizes the memory structure in a weight matrix where the groups are memorized separately. The weight matrix is, thus, in the form of a pile of covariance matrices, each of which is responsible for recalling only the descendants of each ancestor. Putting it simply, the model is multiplex associative memory. The recalling process proceeds as follows: the model first recalls the ancestor of a target descendant. Then, the dynamics with dynamic threshold combines the ancestor and the weight matrix to activate the covariance matrix for recalling only the descendants of the ancestor. This mechanism suppresses the cross-talk noise generated by the descendants of the other ancestors, and the recalling ability is enhanced.

Cascade associative memory storing hierarchically correlated patterns with various correlations.

In conventional models for storing hierarchically correlated patterns, correlations between ancestors (first-level patterns) and their descendants (second-level ones) are assumed to be uniform, so that the descendants are distributed around their ancestors with equal distances. However, this assumption might be unnatural. We believe that objects are encoded into patterns by preserving the similarity between them. In this case, descendants are distributed around their ancestors with various distances, so that the assumption is invalid and the conventional models become inapplicable. To overcome this, we propose a model CASM3 for storing hierarchically correlated patterns with various correlations. In CASM3, critical load levels vary with the descendants, and become higher with increasing correlations. Increase in load level successively destroys the memories of the descendants in descending order of their correlations. The size of the basins of attraction depends on the range of the correlations, and becomes larger as the correlation range is shifted toward lower levels.

A neural network model for visual motion detection that can explain psychophysical and neurophysiological phenomena.

This paper proposes a new neural network model for visual motion detection. The model can well explain both psychophysical findings (the changes of displacement thresholds with stimulus velocity and the perception of apparent motion) and neurophysiological findings (the selectivity for the direction and the velocity of a moving stimulus). To confirm the behavior of the model, numerical examinations were conducted. The results were consistent with both psychophysical and neurophysiological findings.