FDG-PET in the pretherapeutic evaluation of primary squamous cell carcinoma of the oral cavity and the involvement of cervical lymph nodes.

PURPOSE: The diagnostic role of positron emission tomography (PET) with 2-deoxy-2-[18F]fluoro-D-glucose (FDG) in squamous cell carcinoma of the oral cavity is evaluated. PROCEDURES: In 38 patients, the results of FDG-PET, magnetic resonance imaging (MRI), computed tomography (CT), and ultrasound were compared. The standard uptake values (SUV) of FDG-PET were correlated to histopathological grading and DNA-image cytometry. RESULTS: In the case of lymph node metastases, the sensitivity of FDG-PET (93%) was higher than the sensitivity for the compared methods. The specificity was best for CT. SUVs of diploid tumor cell lines seemed to be lower than in non-diploid tumor cell lines. CONCLUSIONS: The high sensitivity and the high negative predictive value of PET may lead to more restrictive therapeutic regimens regarding lymph node metastases. Studies are necessary regarding possible relationships between glucose metabolism and tumor grading.

Analysis of complications in fractures of the mandibular angle--a study with finite element computation and evaluation of data of 277 patients.

AIM: The purpose of this study was to compute the load on different osteosynthesis plates in a simplified model using finite element analysis, and to find out whether miniplates were sufficiently stable for application at the mandibular angle. PATIENTS: Data from 277 patients with 293 fractures of the mandibular angle have been evaluated. METHODS: A computation model using finite elements was established in order to compute mechanical stress occurring in osteosynthesis plates used for fixation of fractures of the mandibular angle. In the second part of this study, the data from all in-patients treated for fracture of the mandibular angle were evaluated retrospectively. Age and sex of the patients, cause of fracture, state of dentition, type of therapy as well as complications were noted. RESULTS: In those tests, both the 1.0 mm miniplate and the 2.3 mm module plate were sufficiently stable. The rate of major complications (requiring revisional surgery with general anaesthesia) amounted to approximately 17% in comminuted fractures, or in non-compliant patients in which primary stability with a single miniplate did not appear sufficient, so that other osteosynthesis methods were used in addition. This rate was considerably higher than that in simple mandibular fractures. Simple fractures of the mandibular angle were just treated with one miniplate following Champy's guidelines strictly. In these fractures the rate of major complications was only 2.3%. CONCLUSION: In comminuted fractures and in non-compliant patients, the use of a stronger osteosynthesis material should be considered while in all other cases application of a single 1.0 mm miniplate was regarded as sufficient for fixation using open reduction.

Histologic study of incorporation and resorption of a bone cement-collagen composite: an in vivo study in the minipig.

OBJECTIVE: Calcium phosphates are clinically established as bone defect fillers. They have the capability of osseoconduction and are characterized by a slow resorption process. The present study evaluated the suitability of a newly developed calcium phosphate cement modified with collagen type I. STUDY DESIGN: The modified cement paste was inserted in differently designed defects of 10 minipigs. Further, an alveolar ridge augmentation was performed, applying the cement paste. The cement hardened in situ during the operation, forming a hydroxyapatite collagen composite. Animals were sacrificed after 1, 3, 6, 12, and 18 months. The tissue integration and resorption process was then evaluated using nondecalcified microsections. All animals were evaluated for histology. RESULTS: The implanted material showed osseoconductive characteristics. Resorption started from the edge of the defect zone, and bone substitution followed rapidly. Twelve months after placement of the cement, complete remodeling was observed. CONCLUSION: It can be concluded that the applied hydroxyapatite-collagen cement composite shows good resorption and bone integration.

Assessment of patients treated for intracapsular fractures of the mandibular condyle by closed techniques.

PURPOSE: The goals to study different lines of intracapsular fractures of the mandibular condyle and to evaluate their influence on the prognosis after closed treatment. PATIENTS AND METHODS: Clinical, radiologic, and axiographic follow-up of 40 patients with 50 intracapsular fractures of the mandibular condyle was carried out after closed treatment. The examinations were performed an average of 22 weeks after treatment. Three types of intracapsular fractures were distinguished: type A, or fractures through the medial condylar pole; type B, or fractures through the lateral condylar pole with loss of vertical height of mandibular ramus, and type M, multiple fragments, comminuted fractures. RESULTS: Moderate to serious dysfunction was observed in 33% of the cases. Radiologic examination of fracture types B and M revealed a reduction in the height of the mandibular ramus of up to 13% compared with the contralateral side. These 2 fracture types also resulted in the most prominent deformations of the condylar head. Axiography revealed irregular excursions and a limitation of condylar movement in comminuted fractures of up to 74% compared with the nonfractured side. CONCLUSION: Lesions to the osseodiscoligamentous complex of the temporomandibular joint caused by intracapsular fractures of the mandibular condyle can be severe. The poor functional and radiologic results encountered in the fracture types B and M showed the limitations of closed functional treatment.