Scientific output of Dutch medical students.

BACKGROUND: In medical curricula, considerable effort is put into scientific education and research training. The output of these efforts, however, is not known. AIM: To assess the number of students who published at least one scientific paper during the course of their medical studies. METHODS: Names and initials of all students who received their medical degree in 2006 or 2007 in one of the six participating university medical centers in the Netherlands were searched in the Web of Science database using a well-validated algorithm. RESULTS: Of the 2973 students, 14.5% had published at least one scientific paper during the last 3 years of their medical studies. These papers were of good quality, as the average number of citations per paper is above the average for papers published in their field. CONCLUSION: Based on the results of our survey, we conclude that medical students in the Netherlands are productively involved in research during their studies. Due to publication delay, the true number of papers is likely to be higher than we counted, but the bibliometric index chosen gives a robust estimate of the effect on the output of the scientific climate of a medical school. Using such an index on a larger scale may stimulate medical faculties to recognize and cultivate academic talent among their students.

Hox collinearity - a new perspective.

Hox collinearity is a spectacular phenomenon that has excited life scientists since its discovery in 1978. Two mechanisms have been proposed to explain the spatially sequential pattern of Hox gene expression in animal embryonic development: interactions among Hox genes, or the progressive opening of chromatin in the Hox clusters, from 3' to 5'. A review of the evidence across different species and developmental stages points to the universal involvement of trans-acting factors and cell-cell interactions. The evidence focuses attention on interactions between Hox genes and on the vertebrate somitogenesis clock. These novel conclusions open new perspectives for the field.