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Science ; 373(6556): 808-812, 2021 08 13.
Artículo en Inglés | MEDLINE | ID: mdl-34385400

RESUMEN

Total daily energy expenditure ("total expenditure") reflects daily energy needs and is a critical variable in human health and physiology, but its trajectory over the life course is poorly studied. We analyzed a large, diverse database of total expenditure measured by the doubly labeled water method for males and females aged 8 days to 95 years. Total expenditure increased with fat-free mass in a power-law manner, with four distinct life stages. Fat-free mass-adjusted expenditure accelerates rapidly in neonates to ~50% above adult values at ~1 year; declines slowly to adult levels by ~20 years; remains stable in adulthood (20 to 60 years), even during pregnancy; then declines in older adults. These changes shed light on human development and aging and should help shape nutrition and health strategies across the life span.


Asunto(s)
Envejecimiento , Metabolismo Energético , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Metabolismo Basal , Composición Corporal , Peso Corporal , Niño , Preescolar , Ejercicio Físico , Femenino , Humanos , Lactante , Recién Nacido , Masculino , Persona de Mediana Edad , Embarazo , Adulto Joven
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