Analysis of pea mutants reveals the conserved role of FRUITFULL controlling the end of flowering and its potential to boost yield.

Monocarpic plants have a single reproductive phase in their life. Therefore, flower and fruit production are restricted to the length of this period. This reproductive strategy involves the regulation of flowering cessation by a coordinated arrest of the growth of the inflorescence meristems, optimizing resource allocation to ensure seed filling. Flowering cessation appears to be a regulated phenomenon in all monocarpic plants. Early studies in several species identified seed production as a major factor triggering inflorescence proliferative arrest. Recently, genetic factors controlling inflorescence arrest, in parallel to the putative signals elicited by seed production, have started to be uncovered in Arabidopsis, with the MADS-box gene FRUITFULL (FUL) playing a central role in the process. However, whether the genetic network regulating arrest is also at play in other species is completely unknown. Here, we show that this role of FUL is not restricted to Arabidopsis but is conserved in another monocarpic species with a different inflorescence structure, field pea, strongly suggesting that the network controlling the end of flowering is common to other plants. Moreover, field trials with lines carrying mutations in pea FUL genes show that they could be used to boost crop yield.

Multimodal Engineering of Catalytic Interfaces Confers Multi-Site Metal-Organic Framework for Internal Preconcentration and Accelerating Redox Kinetics in Lithium-Sulfur Batteries.

The development of highly efficient catalysts to address the shuttle effect and sluggish redox kinetics of lithium polysulfides (LiPSs) in lithium-sulfur batteries (LSBs) remains a formidable challenge. In this study, a series of multi-site catalytic metal-organic frameworks (MSC-MOFs) were elaborated through multimodal molecular engineering to regulate both the reactant diffusion and catalysis processes. MSC-MOFs were crafted with nanocages featuring collaborative specific adsorption/catalytic interfaces formed by exposed mixed-valence metal sites and surrounding adsorption sites. This design facilitates internal preconcentration, a coadsorption mechanism, and continuous efficient catalytic conversion toward polysulfides concurrently. Leveraging these attributes, LSBs with an MSC-MOF-Ti catalytic interlayer demonstrated a 62 % improvement in discharge capacity and cycling stability. This resulted in achieving a high areal capacity (11.57 mAh cm-2 ) at a high sulfur loading (9.32 mg cm-2 ) under lean electrolyte conditions, along with a pouch cell exhibiting an ultra-high gravimetric energy density of 350.8 Wh kg-1 . Lastly, this work introduces a universal strategy for the development of a new class of efficient catalytic MOFs, promoting SRR and suppressing the shuttle effect at the molecular level. The findings shed light on the design of advanced porous catalytic materials for application in high-energy LSBs.

Encapsulating Ni Nanoparticles into Interlayers of Nitrogen-Doped Nb2 CTx MXene to Boost Hydrogen Evolution Reaction in Acid.

Design and development of low-cost and highly efficient non-precious metal electrocatalysts for hydrogen evolution reaction (HER) in an acidic medium are key issues to realize the commercialization of proton exchange membrane water electrolyzers. Ni is regarded as an ideal alternative to substitute Pt for HER based on the similar electronic structure and low price as well. However, low intrinsic activity and poor stability in acid restrict its practical applications. Herein, a new approach is reported to encapsulate Ni nanoparticles (NPs) into interlayer edges of N-doped Nb2 CTx MXene (Ni NPs@N-Nb2 CTx ) by an electrochemical process. The as-prepared Ni NPs@N-Nb2 CTx possesses Pt-like onset potentials and can reach 500 mA cm-2 at overpotentials of only 383 mV, which is much higher than that of N-Nb2 CTx supported Ni NPs synthesized by a wet-chemical method (w- Ni NPs/N-Nb2 CTx ). Furthermore, it shows high durability toward HER with a large current density of 300 mA cm-2 for 24 h because of the encapsulated structure against corrosion, oxidation as well as aggregation of Ni NPs in an acidic medium. Detailed structural characterization and density functional theory calculations reveal that the stronger interaction boosts the HER.

Two-Dimensional Ultrathin Graphic Carbon Nitrides with Extended π-Conjugation as Extraordinary Efficient Hydrogen Evolution Photocatalyst.

Construction of 2D graphic carbon nitrides (g-CNx ) with wide visible light adsorption range and high charge separation efficiency concurrently is of great urgent demand and still very challenging for developing highly efficient photocatalysts for hydrogen evolution. To achieve this goal, a two-step pyrolytic strategy has been applied here to create ultrathin 2D g-CNx with extended the π-conjugation. It is experimentally proven that the extension of π-conjugation in g-CNx is not only beneficial to narrowing the bandgap, but also improving the charge separation efficiency of the g-CNx . As an integral result, extraordinary apparent quantum efficiencies (AQEs) of 57.3% and 7.0% at short (380 nm) and long (520 nm) wavelength, respectively, are achieved. The formation process of the extended π-conjugated structures in the ultrathin 2D g-CNx has been investigated using XRD, FT-IR, Raman, XPS, and EPR. Additionally, it has been illustrated that the two-step pyrolytic strategy is critical for creating ultrathin g-CNx nanosheets with extended π-conjugation by control experiments. This work shows a feasible and effective strategy to simultaneously expand the light adsorption range, enhance charge carrier mobility and depress electron-hole recombination of g-CNx for high-efficient photocatalytic hydrogen evolution.

Stabilize Sodium Metal Anode by Integrated Patterning of Laser-Induced Graphene with Regulated Na Deposition Behavior.

Metallic sodium is regarded as the most potential anode for sodium-ion batteries due to its high capacity and earth-abundancy. Nevertheless, uncontrolled Na dendrite growth and infinite volume change remain great challenges for developing high-performance sodium metal batteries. This work provides a simple and general approach to stabilize sodium metal anode (SMA) by constructing Sn nanoparticles-anchored laser-induced graphene on copper foil (Sn@LIG@Cu) consisting of Sn@LIG composite, polyimide (PI) columns, and Cu current collector. The Sn-based sodiophilic species effectively reduce the Na nucleation overpotential and regulate the dendrite Na-free deposition. While the flexible PI columns act as binder and buffer the volume variation of Na during cycling. Besides, the unique patterned structure provides continuous and rapid channels for ion transportation, promoting the Na+ transport kinetics. Therefore, the as-fabricated Sn@LIG@Cu electrode exhibits outstanding rate performance to 40 mA cm-2 and excellent cycling stability without dendrite growth, which is confirmed by in-situ optical microscopy observation. Moreover, the practical full cell based on such an anode displays a favorable rate capability of up to 10 C and cycling performance at 5 C for 600 cycles. This work thus demonstrates a facile, highly-efficient, and scalable approach to stabilize SMAs and can be extended to other battery systems.

Low-Temperature Vapor-Phase Growth of 2D Metal Chalcogenides.

2D metal chalcogenides (MCs) have garnered significant attention from both scientific and industrial communities due to their potential in developing next-generation functional devices. Vapor-phase deposition methods have proven highly effective in fabricating high-quality 2D MCs. Nevertheless, the conventionally high thermal budgets required for synthesizing 2D MCs pose limitations, particularly in the integration of multiple components and in specialized applications (such as flexible electronics). To overcome these challenges, it is desirable to reduce the thermal energy requirements, thus facilitating the growth of various 2D MCs at lower temperatures. Numerous endeavors have been undertaken to develop low-temperature vapor-phase growth techniques for 2D MCs, and this review aims to provide an overview of the latest advances in low-temperature vapor-phase growth of 2D MCs. Initially, the review highlights the latest progress in achieving high-quality 2D MCs through various low-temperature vapor-phase techniques, including chemical vapor deposition (CVD), metal-organic CVD, plasma-enhanced CVD, atomic layer deposition (ALD), etc. The strengths and current limitations of these methods are also evaluated. Subsequently, the review consolidates the diverse applications of 2D MCs grown at low temperatures, covering fields such as electronics, optoelectronics, flexible devices, and catalysis. Finally, current challenges and future research directions are briefly discussed, considering the most recent progress in the field.

En Route to High-Density Chiral Single-walled Carbon Nanotube Arrays using Solid Trojan Catalysts.

Solid catalyst is widely recognized as an effective strategy to control the chirality of single-walled carbon nanotubes (SWNTs). However, it is still not compatible with high density in horizontal arrays. "Trojan" catalysts strategy is one of the most effective methods to realize SWNTs with high density and has great potential in chirality control. Here, the co-realization of high density and chirality controlling for SWNTs in a low-temperature growth process is reported based on the developed solid "Trojan" catalyst. High temperature "Trojan" catalyst formation process provides sufficient catalyst number to acquire high density. These liquid "Trojan" catalysts are cooled to solid state by adopting low growth temperature (540 °C), which can be good template to realize the chirality controlling of SWNTs with exposing six-fold symmetry face, (111). Finally, (9, 6) and (13, 1) SWNTs enriched horizontal array with the purity of ≈90% and density of 4 tubes µm-1 is realized. The comparison between the distribution of initial catalysts and the density of as-grown tubes indicates no sacrificing on catalysts number to improve chirality selectivity. This work opens a new avenue on the catalyst's design and chirality controlling in SWNTs growth.

Covalent Organic Framework with Multi-Cationic Molecular Chains for Gate Mechanism Controlled Superionic Conduction in All-Solid-State Batteries.

Although solid-state batteries (SSBs) are high potential in achieving better safety and higher energy density, current solid-state electrolytes (SSEs) cannot fully satisfy the complicated requirements of SSBs. Herein, a covalent organic framework (COF) with multi-cationic molecular chains (COF-MCMC) was developed as an efficient SSE. The MCMCs chemically anchored on COF channels were generated by nano-confined copolymerization of cationic ionic liquid monomers, which can function as Li+ selective gates. The coulombic interaction between MCMCs and anions leads to easier dissociation of Li+ from coordinated states, and thus Li+ transport is accelerated. While the movement of anions is restrained due to the charge interaction, resulting in a high Li+ conductivity of 4.9×10-4  S cm-1 and Li+ transference number of 0.71 at 30 °C. The SSBs with COF-MCMC demonstrate an excellent specific energy density of 403.4 Wh kg-1 with high cathode loading and limited Li metal source.

Amorphous Tellurium-Embedded Hierarchical Porous Carbon Nanofibers as High-Rate and Long-Life Electrodes for Potassium-Ion Batteries.

Tellurium (Te) is a promising electrode active material for potassium-ion batteries due to its intrinsic electrical conductivity and ultra-high theoretical volumetric capacity. Nevertheless, Te-based electrodes usually exhibit low capacity at high rates and poor cycling stability caused by the large volume expansion and severe polytellurides dissolution. Herein, hierarchical porous carbon nanofibers (HPCNFs) film is utilized as a multifunctional Te substrate. The free-standing Te@HPCNFs electrode renders an outstanding K-ion storage performance with a high-rate capacity of 1294.4 mAh cm-3 (207.1 mAh g-1 Te ) at 14C and ultra-long lifespan for 4500 cycles at 7C, and K-ion full batteries coupled with KSn alloy anode also exhibit good cyclability. Such a superior performance benefits from the space confinement of HPCNFs to load amorphous Te in the micropores for accommodating the volume change, where the interconnected conductive frameworks and residual hierarchical pores enable fast ion/electron diffusion kinetics. In situ UV-vis absorption spectra confirm that the detachment of polytellurides and K2 Te from the electrode is effectively suppressed, and ex situ X-ray photoelectron spectroscopy analysis reveals the conversion of Te into K5 Te3 and K2 Te. This work presents the significance of porous structure design of carbon matrix to construct high performance Te electrodes, which will be instructive for chalcogens-based energy-storage materials.

MOF-Derived Pt/ZrO2 Carbon Electrocatalyst for Efficient Hydrogen Evolution.

One type of porous carbon nanomaterial decorated by abundant Pt/ZrO2 nanoparticles can be conveniently prepared, which is pyrolyzed from flower-shaped Zr-based UiO-67 precursor with a small amount of H2PtCl6 molecules in its large pores. In addition, the obtained Pt/ZrO2 carbon electrocatalyst can bring efficient electrocatalytic hydrogen evolution performance and long-term stability.

Morphologically Controlled Metal-Organic Framework-Derived FeNi Oxides for Efficient Water Oxidation.

The complex oxygen evolution reaction (OER) is recognized as the most studied and explored electrochemical conversion, which plays a crucial role in energy-related applications. In this work, a series of metal-organic framework (MOF)-derived FeNi oxides from a barrel-shaped Ni-based BMM-10 precursor are conveniently obtained to show an excellent OER performance. Under mild Fe(III) etching, a type of core-shell Fe0.5-BMM-10 can be well preserved and the coordination bond of the middle frame structure is decomposed. Furthermore, the Fex-BMM-10-T series is successfully synthesized with a well-preserved morphology compared to precursors after direct oxidation. Finally, followed by initial electrochemical activation, the decomposition of FeNi oxides generates active Fe-doped nickel oxyhydroxides for efficient water oxidation. The improved OER performance stems from the high specific surface area and abundant exposed active centers, as well as the significant synergistic effect between iron and nickel, which is further verified by the theoretical calculation. This approach can be extended to precisely adjust the morphology of MOFs and their derivatives that can result in superior electrocatalytic properties in terms of energy conversion and storage applications.

Recent Advances in Electrocatalysts for Alkaline Hydrogen Oxidation Reaction.

With the rapid development of anion-exchange membrane technology and adequate supply of high-performance non-noble metal oxygen reduction reaction (ORR) catalysts in alkaline media, the commercialization of anion exchange membrane fuel cells (AEMFCs) become possible. However, the kinetics of the anodic hydrogen oxidation reaction (HOR) in AEMFCs is significantly decreased compared to the HOR in proton exchange membrane fuel cells (PEMFCs). Therefore, it is urgent to develop HOR catalysts with low price, high activity, and robust stability. However, comprehensive timely reviews on this specific subject do not exist enough yet and it is necessary to update reported major achievements and to point out future investigation directions. In this review, the current reaction mechanisms on HOR are summarized and deeply understood. The debates between the mechanisms are greatly harmonized. Recent advances in developing highly active and stable electrocatalysts for the HOR are reviewed. Moreover, the side reaction control is for the first time systematically introduced. Finally, the challenges and future opportunities in the field of HOR catalysis are outlined.

Sulfur-Induced Growth of Coordination Polymer Derived-Straight Carbon Nanotubes on Carbon Nanofiber Network for Zn-Air Batteries.

Low-cost heteroatom-doped carbon nanomaterials have been widely studied for efficient oxygen reduction reaction and energy storage and conversion in metal-air batteries. A Masson pine twigs-like 3-dimensional network construction of carbon nanofibers (CNFs) with abundant straight long Co, N, and S-doped carbon nanotubes (CNTs) is developed by thermal treatment of Co-based polymer coated onto polyacrylonitrile nanofiber network together with thiourea at 900 °C, denoted as CNFT-Co9 S8 -900. It is interesting to note that the introduction of a high concentration of sulfur does not lead to the complete toxicity of catalysts, but promotes the axial growth to selectively form straight CNTs instead of curly bamboo-like CNTs. The highly graphitized in-situ grown Co, N, S-doped CNTs and the 3-dimensional N-doped CNF network provide both active catalytic sites and highly conductive paths, which are beneficial for oxygen reduction reaction (ORR). Thus, the optimal CNFT-Co9 S8 -900 performs the excellent ORR catalytic activity with a half-wave potential of 0.84 V and a diffusion-limited current density of 5.49 mA cm-2 . Furthermore, the CNFT-Co9 S8 -900-based Zn-air devices also possess a high power density of 136.9 mW cm-2 better than commercial Pt/C.

MALT1 positively correlates with Th1 cells, Th17 cells, and their secreted cytokines and also relates to disease risk, severity, and prognosis of acute ischemic stroke.

BACKGROUND: This study aimed to explore the association of mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) with acute ischemic stroke (AIS) risk and also to explore its association with T helper type 1 (Th1) cells, Th17 cells, disease severity, and prognosis in AIS patients. METHODS: One hundred twenty first-episode AIS patients and 120 non-AIS patients with high-stroke-risk factors (as controls) were recruited. Besides, in the cluster of differentiation 4-positive (CD4+ ) T cells, the MALT1 gene expression was detected by reverse transcription quantitative polymerase chain reaction; meanwhile, Th1 and Th17 were detected by flow cytometry. Moreover, serum interferon (IFN)-γ and interleukin (IL)-17 were determined by enzyme-linked immunosorbent assay. RESULTS: MALT1 expression was increased in AIS patients compared with controls and also it could differentiate AIS patients from controls, with an area under curve of 0.905 (95% confidence interval: 0.869-0.941). In AIS patients, MALT1 positively correlated with Th1 cells, Th17 cells, IFN-γ, and IL-17. Besides, MALT1 positively correlated with the National Institutes of Health Stroke Scale score. Furthermore, the Kaplan-Meier curve and univariate Cox's regression analyses showed no correlation of MALT1 high expression with recurrence-free survival (RFS) in AIS patients, although after adjustment using multivariant Cox's regression, high MALT1 expression independently correlated with worse RFS in AIS patients. CONCLUSION: MALT1 expression is increased and positively correlates with disease severity, Th1 cells, and Th17 cells, whose high expression severs as an independent risk factor for worse RFS in AIS patients.

"Zuòyuèzi" dietary and behavioural associations with maternal health among puerperal women in South China.

BACKGROUND AND OBJECTIVES: This study aimed to explore the associations of postpartum dietary quality and behavioral practices with maternal health in Guangzhou China. METHODS AND STUDY DESIGN: We conducted a cross-sectional study among puerperal women in urban and suburban areas in Guangzhou, China (n=2013). Data for postpartum dietary and behavioral practices and health conditions were collected by a standardized questionnaire. Dietary balance index (DBI) was calculated to assess an individual's dietary quality. Logistic regression analysis was used to identify the factors related to women's health. RESULTS: 75.5% of women reported at least one postpartum disease, and the most common problems were prolonged duration of lochia (70.0%) and backache (43.0%), followed by constipation (23.6%), insufficient milk secretion (19.2%), breast swelling (18.5%) and hemorrhoids (13.8%). Average postpartum weight retention was 3.5 kg. Logistic regression analysis revealed that 12-18 h/d of bed rest time, breastfeeding, doing postpartum exercise, basking, getting out of bed within 2 days after delivery, higher intake of fish and shrimp, fruits, vegetable, milk were protective factors for at least one out of these health problems or weight retention (p<0.05). Bed rest time for more than 18 h/d or less than 12 h/d, ginger vinegar intake, doing housework, cesarean section, and excessive and inadequate intake of cereals had an adverse association (p<0.05). CONCLUSIONS: Some features of a traditional Chinese postpartum diet and behaviour are related to maternal morbidity during the puerperium. Further studies are needed to assess whether postpartum diet and behavioral intervention improve maternal health during the postpartum period.

Methylation-Induced Reversible Metallic-Semiconducting Transition of Single-Walled Carbon Nanotube Arrays for High-Performance Field-Effect Transistors.

Acquirement of aligned semiconducting single-walled carbon nanotube (s-SWNT) arrays is one of the most promising directions to break Moore's Law, thus developing the next-generation electronic devices. Despite that widespread approaches have been developed, it is still a great challenge to facilely prepare s-SWNT arrays with tunable electronic properties. Herein, a different perspective is proposed to produce s-SWNT arrays by implementing reversible methylation reactions on the as-grown aligned SWNT arrays. In this way, the metallic single-walled carbon nanotubes (m-SWNTs) are selectively and reversibly methylated to acquire semiconducting properties, to afford tunable electronic properties of the as-obtained SWNT arrays in a highly controllable and simple manner. Electrical measurements suggest a high fraction of s-SWNTs is attained (>97.5%) after methylation, facilitating its exceptional performance as a field-effect transistor (FET) with an on-off ratio of up to 17543. This method may provide a new way for the preparation of s-SWNT arrays with tunable electronic properties and impressive prospects toward the fabrication of high-performance FETs.

Surfactant-Mediated Morphological Evolution of MnCo Prussian Blue Structures.

In the preparation of nanomaterials, the kinetics and thermodynamics in the reaction can significantly affect the structures and phases of nanocrystals. Therefore, people are keen to adopt various synthetic strategies to accurately assemble the target nanocrystals, and reveal the underlying mechanism of the formation of specific structures. In this work, the total reaction time is adjusted to let the prepared MnCo Prussian blue analogous (MnCoPBA) crystals show four evolving morphological changes at different stages with the assistance of sodium dodecyl sulfate. Furthermore, it is clearly observed that the epitaxial growth along the (100) plane on the shell of MnCoPBA nanocrystals is favored, and the thermodynamics and kinetics in the morphology change process are analyzed in detail. Through the simple pyrolysis, MnCoPBA crystals can be successfully converted into the corresponding carbon composites, of which Mn2 Co2 C nanoparticles are evenly distributed in highly graphitized carbon matrix. Among them, PBA-III-700 performs good oxygen reduction reaction performance in alkaline solution with the half-wave potential of 0.801 V and diffusion-limited current density of 5.36 mA cm-2 , and its zinc-air battery exhibits the peak power density of 103.4 mW cm-2 competitive with commercial Pt/C.

Structural and Morphological Conversion between Two Co-Based MOFs for Enhanced Water Oxidation.

The rapid development of suitable and cheap water oxidation catalysts is of great significance in energy conversion and storage. In this context, herein we have synthesized two different types of metal-organic frameworks (MOFs, denoted as BMM-11 and BMM-12) constructed from the same metal salts (cobalt nitrate) and organic linkers (H4BPTC) at the similar solvothermal conditions. Interestingly, we learned that both crystalline materials can be conveniently converted into each other by a single-crystal-to-single-crystal transformation method at their corresponding synthetic conditions. Meanwhile, we applied them directly as electrocatalysts into OER application where the pure BMM-11 and BMM-12 can achieve a stable current density of 10 mA cm-2 with an overpotential of 0.362 and 0.393 V, respectively, during which MOF degradation unexpectedly occurs. After electrolysis, the following microscopic, spectroscopic, as well as electrochemical measurements confirm that these initial MOF precursors are rapidly transformed into the mixed phases of CoOxHy species consisting of CoOOH and Co(OH)2, which are essentially active components for OER performance. Finally, we have also considered other strategies to improve MOF-derived composites in oxygen evolution activity, including bimetallic doping and physical grinding strategy. The approach described here can further be extended to other cobalt-based MOFs-derived electrocatalysts for water splitting.

Highly efficient utilization of light and charge separation over a hematite photoanode achieved through a noncontact photonic crystal film for photoelectrochemical water splitting.

The trade-off problem between light absorption and charge collection under lower band-bending (bias) is extremely difficult to resolve in water splitting on photoelectrodes. Although the use of metallic back-reflectors, antireflection coatings, and textured substrates and light absorbers enable the improvement of light utilization efficiency, these methods still suffer from high cost and complex fabrication process, especially, incompetent separation of photogenerated carriers. Here taking the hematite (α-Fe2O3) photoanode as a model, we report that a noncontact photonic crystal (PC) film composed of silica nanoparticles and ethoxylated trimethylolpropane triacrylate (ETPTA) resin can significantly enhance the photoelectrochemical (PEC) activity of the photoelectrode. Specifically, more than 250 mV cathodic shift in the onset potential and 4 times larger photocurrent at 1.0 V versus a reversible hydrogen electrode (RHE) were achieved over the α-Fe2O3-PC photoanode hybrid system, compared with the pristine α-Fe2O3 photoanode. Our work showed that a PC film not only boosted light absorption of the α-Fe2O3 layer but also improved its charge transfer efficiency under light illumination. These new findings of the synergistic effect will open a new avenue to design high-performance solar energy conversion devices.

Long noncoding RNA HULC in acute ischemic stroke: Association with disease risk, severity, and recurrence-free survival and relation with IL-6, ICAM1, miR-9, and miR-195.

BACKGROUND: This study aimed to evaluate the clinical role of long noncoding RNA (lncRNA) HULC in acute ischemic stroke (AIS). METHODS: LncRNA HULC in plasma samples from 215 first episode AIS patients and 215 age/gender-matched non-AIS controls was detected by reverse transcriptional-quantitative polymerase chain reaction (RT-qPCR). Then, in AIS patients, interleukin-6 and intercellular adhesion molecule 1 (ICAM1), as well as microRNA (miR) target of lncRNA HUCL (miR-9 and miR-195), were detected by enzyme-linked immunosorbent assay and RT-qPCR, respectively. Disease severity was assessed by National Institution of Health stroke scale (NIHSS) score. AIS recurrence or death was recorded, and recurrence-free survival (RFS) was calculated. RESULTS: LncRNA HULC was increased in AIS patients compared to non-AIS controls (P < .001), and receiver operating characteristic curve showed that it was correlated with increased AIS risk (area under curve: 0.876, 95% confidence interval: 0.843-0.908). Meanwhile, lncRNA HULC was positively correlated with NIHSS score (P < .001, r = .456), interleukin-6 (P < .001, r = .275) and ICAM1 (P < .001, r = .383), whereas negatively correlated with miR-9 (P < .001, r = -.438) but not miR-195 (P = .205, r = -.087) in AIS patients. Additionally, miR-9 was negatively correlated with NIHSS score (P < .001, r = -.335), interleukin-6 (P = .001, r = -.231), and ICAM1 (P < .001, r = -.280), while miR-195 was only negatively associated with NIHSS score (P = .041, r = -.139) in AIS patients. Moreover, lncRNA HULC high expression predicted worse RFS (P = .013) in AIS patients. CONCLUSION: LncRNA HULC is correlated with higher AIS risk, increased disease severity and worse prognosis in AIS patients. Meanwhile, it associates with higher IL-6, elevated ICAM1, and lower miR-9 AIS patients.