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Food Funct ; 13(14): 7487-7493, 2022 Jul 18.
Artículo en Inglés | MEDLINE | ID: mdl-35762857

RESUMEN

Resveratrol (RSV) was known to be metabolised by the gut microbiota to dihydroresveratrol, lunularin (LUNU), and (or) 3,4'-dihydroxy-trans-stilbene (DHST). We describe here for the first time that LUNU can be further dehydroxylated, but only at the 3-position, to yield 4-hydroxydibenzyl, a novel metabolite found in human urine after RSV intake in 41 out of 59 healthy participants. In contrast, DHST was not further dehydroxylated, and thus, 4-hydroxy-trans-stilbene was not detected as a gut microbial metabolite of RSV. Faecal in vitro incubations confirmed the in vivo results.


Asunto(s)
Microbioma Gastrointestinal , Estilbenos , Antioxidantes , Heces , Humanos , Resveratrol , Estilbenos/farmacología
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