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Bioorg Med Chem Lett
; 20(5): 1589-92, 2010 Mar 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-20138513
RESUMEN
A series of N1-alkyl pyrimidinediones were designed, synthesized and evaluated as HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs). Our efforts identified compound 10b, which represents the lead compound in this series with pharmacokinetics and antiviral potency that may support once-daily dosing.