Biocompatible dressing for pediatric hypospadias repair.

PURPOSE: The search for an ideal Hypospadias repair dressing continues. We aimed to develop a hypoallergenic optimized biocompatible dressing (BD). METHOD: BD with a multi-layered structure of hydrophilic treated Polypropylene with three-layered technologies; Absorbent-spunlaced hydroentangled polyester/viscose blend, outer Polypropylene, Polyester, Acrylic, and Spandex, with super Absorbent Polymer and Acrylic adhesive. Wistar rat abdominal wound model was divided into two groups: control (normal gauze dressing with adhesive) and Study (BD). The physical properties and wound characteristics were compared. RESULTS: Average mass: thickness of BD was 626.7 ± 5.6 g m-2: 2.6 ± 0.015 mm. Absorption was 1425.2 ± 127.6%. Percentage desorption of solution A from dressings at 24:40 h was 1249 ± 150%:1417 ± 230%. BD was hydrophilic with no particles/residue after immersion and pH neutral. The average air permeability was 11.6 ± 1.6 cm3/cm2/sec. The tensile force was 200N-220N with an extension on the breaking point at 24 mm. BD was superior for ease of removability on Day 6 (p = 0.012) and sticking quality (p = 0.036), absorption (p = 0.036), ease of removability(p = 0.036), and sustenance (p = 0.030) on Day 10. BD dressing demonstrated better wound healing (p = 0.015) and decreased redness (p = 0.002) on Day 10. Histopathological healing was better with BD on Day 14(p = 0.025) and Day 20 (p = 0.034). CONCLUSION: BD demonstrated better desirable physical and wound healing qualities with less inflammation compared with control normal dressing.

Metal-organic frameworks functionalized smart textiles for adsorptive removal of hazardous aromatic pollutants from ambient air.

Organic pollutants, with their increasing concentrations in the ambient air, are posing a severe threat to human health. Metal-organic frameworks (MOFs), due to their active functionalities and porous nature, have emerged as potential materials for the capture of organic pollutants and cleaning of the environment/air. In this work, the functionalization of cotton fabric is reported by the in-situ growth of zeolitic imidazolate framework (ZIF-8 and ZIF-67) MOFs on carboxymethylated cotton (CM Cotton) by employing a rapid and eco-friendly approach. The physicochemical characterization of the MOF functionalized fabrics (ZIF-8@CM Cotton and ZIF-67@CM Cotton) revealed uniform and wash durable attachment of porous ZIF nanocrystals on the surface of the fabric. These ZIF functionalized fabrics possessed high surface area and have been observed to adsorb significantly high concentrations of organic pollutants such as aniline, benzene, and styrene from ambient air. Interestingly these fabrics could be regenerated and reused repeatedly without any deterioration in their adsorption capacity. The negative and low binding energies calculated by DFT confirmed the physisorption of the aromatic pollutants on the surface of MOF functionalized fabrics. Such fabrics have a huge potential as protective textiles, anti-odor clothing, air purification filters, and related products.