RESUMEN
Excess soluble fms-like tyrosine kinase 1 (sFlt-1), a soluble inhibitor of vascular endothelial growth factor pathway, has been demonstrated to promote endothelial dysfunction. Here, we demonstrate that sFlt-1 plasma levels correlate with respiratory symptom severity, expression of endothelial dysfunction biomarker, and incidence of organ failure in coronavirus disease 2019 patients. Clinical Trials Registration: NCT04394195.
Asunto(s)
COVID-19 , Receptor 1 de Factores de Crecimiento Endotelial Vascular , Enfermedad Crítica , Humanos , SARS-CoV-2 , Factor A de Crecimiento Endotelial VascularRESUMEN
Since there was no French tool adapted to the reality of people with autism enrolled in a work integration program in Quebec, we have modified the Profile of Rehabilitation and Adaptation in a Work Context for People with Intellectual Disabilities according to the scientific literature on autism. Content validity (n=17) and applicability (n=5) were done with success. Result is an Excel compiler containing 3 informative tabs, 10 tabs on the dimensions of work rehabilitation (59 items) and 4 tabs used to compile the results. Socio-professional practicians are welcomed to use this new tool to pursue construct and internal validity.
Asunto(s)
Trastorno Autístico , Discapacidad Intelectual , Medicina , Humanos , Lugar de Trabajo , QuebecRESUMEN
To facilitate the integration of people with autism into the food industry labour market, this cross sectoral project aimed to design, validate and test instructional videos to concretely demonstrate various tasks in the grocery store, and to probe interest and assess knowledge about these tasks. Results are the delivery of 21 instructional videos validated for individuals with autism and 21 for mentors in grocery.
Asunto(s)
Trastorno Autístico , Humanos , Supermercados , Escolaridad , Aprendizaje , ComercioRESUMEN
Originality and relevance are not the only factors in the success of innovative programs. Community consensus, expertise and credibility of staff, and evaluative approaches are important as well. Virgule ("Comma"), a program aimed at helping 10- and 11-year-olds who are first offenders, has these characteristics. The temporary hitch in the youth's life is viewed not as a definitive failure but as an opportunity for change. This is Virgule's philosophy: "Changing a period into a comma means changing a difficulty into a reason for progress."