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1.
Support to early clinical decisions in drug development and personalised medicine with checkpoint inhibitors using dynamic biomarker-overall survival models.
Br J Cancer
; 129(9): 1383-1388, 2023 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-36765177
2.
A longitudinal model for the Mayo Clinical Score and its sub-components in patients with ulcerative colitis.
J Pharmacokinet Pharmacodyn
; 49(2): 179-190, 2022 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-34657238
3.
Assessment of pharmacokinetic linearity after repeated drug administration.
Pharm Stat
; 21(5): 932-943, 2022 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-35297534
4.
Confounding factors in exposure-response analyses and mitigation strategies for monoclonal antibodies in oncology.
Br J Clin Pharmacol
; 87(6): 2493-2501, 2021 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-33217012
5.
Platform model describing pharmacokinetic properties of vc-MMAE antibody-drug conjugates.
J Pharmacokinet Pharmacodyn
; 44(6): 537-548, 2017 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-28918591
6.
Estimation of drug receptor occupancy when non-displaceable binding differs between brain regions extending the simplified reference tissue model.
Br J Clin Pharmacol
; 80(1): 116-27, 2015 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-25406494
7.
Improved precision of exposure-response relationships by optimal dose-selection. Examples from studies of receptor occupancy using PET and dose finding for neuropathic pain treatment.
J Pharmacokinet Pharmacodyn
; 42(3): 211-24, 2015 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-25792005
8.
Simulation-based evaluation of personalized dosing approaches for anti-FGFR/KLB bispecific antibody fazpilodemab.
CPT Pharmacometrics Syst Pharmacol
; 13(4): 544-550, 2024 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-38343040
9.
gPKPDviz: A flexible R shiny tool for pharmacokinetic/pharmacodynamic simulations using mrgsolve.
CPT Pharmacometrics Syst Pharmacol
; 13(3): 341-358, 2024 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-38082557
10.
A positron emission tomography study in healthy volunteers to estimate mGluR5 receptor occupancy of AZD2066 - estimating occupancy in the absence of a reference region.
Neuroimage
; 82: 160-9, 2013 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23668965
11.
Norepinephrine transporter occupancy in the human brain after oral administration of quetiapine XR.
Int J Neuropsychopharmacol
; 16(10): 2235-44, 2013 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-23809226
12.
A disease model predicting placebo response and remission status of patients with ulcerative colitis using modified Mayo score.
Clin Transl Sci
; 16(11): 2310-2322, 2023 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-37718498
13.
Population Pharmacokinetics of Ranibizumab Delivered via the Port Delivery System Implanted in the Eye in Patients with Neovascular Age-Related Macular Degeneration.
J Clin Pharmacol
; 63(11): 1210-1220, 2023 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-37291950
14.
Non-linear mixed effects modelling of positron emission tomography data for simultaneous estimation of radioligand kinetics and occupancy in healthy volunteers.
Neuroimage
; 61(4): 849-56, 2012 Jul 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-22425672
15.
Pharmacokinetics of the Port Delivery System with Ranibizumab in the Ladder Phase 2 Trial for Neovascular Age-Related Macular Degeneration.
Ophthalmol Ther
; 11(5): 1705-1717, 2022 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-35759124
16.
Model-Informed Therapeutic Dose Optimization Strategies for Antibody-Drug Conjugates in Oncology: What Can We Learn From US Food and Drug Administration-Approved Antibody-Drug Conjugates?
Clin Pharmacol Ther
; 110(5): 1216-1230, 2021 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-33899934
17.
Population pharmacokinetic and exploratory exposure-response analysis of the fixed-dose combination of pertuzumab and trastuzumab for subcutaneous injection in patients with HER2-positive early breast cancer in the FeDeriCa study.
Cancer Chemother Pharmacol
; 88(3): 499-512, 2021 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-34106303
18.
A New Method to Model and Predict Progression Free Survival Based on Tumor Growth Dynamics.
CPT Pharmacometrics Syst Pharmacol
; 9(3): 177-184, 2020 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-32036626
19.
Analysis of Longitudinal-Ordered Categorical Data for Muscle Spasm Adverse Event of Vismodegib: Comparison Between Different Pharmacometric Models.
CPT Pharmacometrics Syst Pharmacol
; 9(2): 96-105, 2020 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-31877239
20.
Intrinsic and Extrinsic Pharmacokinetic Variability of Small Molecule Targeted Cancer Therapy.
Clin Transl Sci
; 13(2): 410-418, 2020 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-31729137