Detalles de la búsqueda
1.
Monomethyl Auristatin E (MMAE), a Payload for Multiple Antibody Drug Conjugates (ADCs), Demonstrates Differential Red Blood Cell Partitioning Across Human and Animal Species.
Xenobiotica
; : 1-13, 2024 Apr 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-38647387
2.
Translational PK/PD framework for antibody-drug conjugates to inform drug discovery and development.
Xenobiotica
; : 1-11, 2024 May 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-38738473
3.
Nonclinical toxicology development of a novel antibody antibiotic conjugate for treating invasive Staphylococcus Aureus infections.
Toxicol Appl Pharmacol
; 435: 115811, 2022 01 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-34896194
4.
Anti-Lymphocyte Antigen 6 Complex, Locus E-Seco-Cyclopropabenzindol-4-One-Dimer Antibody-Drug Conjugate That Forms Adduct with α1-Microglobulin Demonstrates Slower Systemic Antibody Clearance and Reduced Tumor Distribution in Animals.
Drug Metab Dispos
; 48(12): 1247-1256, 2020 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-33020064
5.
Characterization of Tissue Distribution, Catabolism, and Elimination of an Anti-Staphylococcus aureus THIOMAB Antibody-Antibiotic Conjugate in Rats.
Drug Metab Dispos
; 48(11): 1161-1168, 2020 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-32839277
6.
Antibody-mediated delivery of chimeric protein degraders which target estrogen receptor alpha (ERα).
Bioorg Med Chem Lett
; 30(4): 126907, 2020 02 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-31902710
7.
A Phase 1, Randomized, Single-Ascending-Dose Study To Investigate the Safety, Tolerability, and Pharmacokinetics of DSTA4637S, an Anti-Staphylococcus aureus Thiomab Antibody-Antibiotic Conjugate, in Healthy Volunteers.
Antimicrob Agents Chemother
; 63(6)2019 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-30910894
8.
Hyaluronic Acid-Antibody Fragment Bioconjugates for Extended Ocular Pharmacokinetics.
Bioconjug Chem
; 30(11): 2782-2789, 2019 11 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-31553572
9.
Antibody-Drug Conjugates Derived from Cytotoxic seco-CBI-Dimer Payloads Are Highly Efficacious in Xenograft Models and Form Protein Adducts In Vivo.
Bioconjug Chem
; 30(5): 1356-1370, 2019 05 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30966735
10.
Attachment Site Cysteine Thiol pKa Is a Key Driver for Site-Dependent Stability of THIOMAB Antibody-Drug Conjugates.
Bioconjug Chem
; 28(10): 2538-2548, 2017 10 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-28885827
11.
Current Approaches for Absorption, Distribution, Metabolism, and Excretion Characterization of Antibody-Drug Conjugates: An Industry White Paper.
Drug Metab Dispos
; 44(5): 617-23, 2016 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-26669328
12.
Translational pharmacokinetics and pharmacodynamics of monoclonal antibodies.
Drug Discov Today Technol
; 21-22: 75-83, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-27978991
13.
Peripheral neuropathy with microtubule inhibitor containing antibody drug conjugates: Challenges and perspectives in translatability from nonclinical toxicology studies to the clinic.
Regul Toxicol Pharmacol
; 82: 1-13, 2016 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-27773754
14.
Challenges and advances in the assessment of the disposition of antibody-drug conjugates.
Biopharm Drug Dispos
; 37(2): 66-74, 2016 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-25904406
15.
Preclinical Pharmacokinetic Considerations for the Development of Antibody Drug Conjugates.
Pharm Res
; 32(11): 3470-9, 2015 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-25446773
16.
A Minimal PBPK/PD Model with Expansion-Enhanced Target-Mediated Drug Disposition to Support a First-in-Human Clinical Study Design for a FLT3L-Fc Molecule.
Pharmaceutics
; 16(5)2024 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-38794321
17.
A Bispecific Modeling Framework Enables the Prediction of Efficacy, Toxicity, and Optimal Molecular Design of Bispecific Antibodies Targeting MerTK.
AAPS J
; 26(1): 11, 2024 Jan 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-38167740
18.
The HER2-directed antibody-drug conjugate DHES0815A in advanced and/or metastatic breast cancer: preclinical characterization and phase 1 trial results.
Nat Commun
; 15(1): 466, 2024 Jan 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-38212321
19.
Engineering upper hinge improves stability and effector function of a human IgG1.
J Biol Chem
; 287(8): 5891-7, 2012 Feb 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-22203673
20.
Utilizing PK and PD Biomarkers to Guide the First-in-Human Starting Dose Selection of MTBT1466A: A Novel Humanized Monoclonal Anti-TGFß3 Antibody for the Treatment of Fibrotic Diseases.
J Pharm Sci
; 112(11): 2910-2920, 2023 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-37429356