RESUMEN
Two new drimane sesquiterpenoids, changweikangic acid A (1) and B (2), were isolated from Compound Changweikang. Their structures were established on basis of extensive spectroscopic analyses including two dimensional (2D) NMR and X-ray crystallographic data. The two compounds were evaluated for their inhibitory activity against nitric oxide production in lipopolysaccharide-activated macrophage cell line, RAW 264.7 cells.
Asunto(s)
Antiinflamatorios/química , Antiinflamatorios/farmacología , Medicamentos Herbarios Chinos/química , Medicamentos Herbarios Chinos/farmacología , Óxido Nítrico/antagonistas & inhibidores , Sesquiterpenos/química , Sesquiterpenos/farmacología , Animales , Antiinflamatorios/aislamiento & purificación , Línea Celular , Cristalografía por Rayos X , Medicamentos Herbarios Chinos/aislamiento & purificación , Helechos/química , Lipopolisacáridos/inmunología , Macrófagos/efectos de los fármacos , Macrófagos/inmunología , Ratones , Modelos Moleculares , Óxido Nítrico/inmunología , Sesquiterpenos Policíclicos , Polygonum/química , Sesquiterpenos/aislamiento & purificaciónRESUMEN
Two new compounds, 1,3-bis(m-carboxylphenyl)-propan-2-one (1) and 2-(m-carboxylphenyl)-3-(m-carboxylbenzyl) succinic acid (2), were isolated from the barks of Cerbera manghas, and their structures were established on the basis of spectroscopic methods.
Asunto(s)
Acetona/análogos & derivados , Acetona/aislamiento & purificación , Apocynaceae/química , Medicamentos Herbarios Chinos/química , Succinatos/aislamiento & purificación , Acetona/química , Estructura Molecular , Resonancia Magnética Nuclear Biomolecular , Corteza de la Planta/química , Succinatos/químicaRESUMEN
OBJECTIVE: To study the constituents of the leaves of Heliciopsis lobata. METHOD: Compounds were isolated by column chromatography on silica gel, neutral aluminum oxide and Sephadex LH -20, and their structures were identified by spectroscopic and physicochemical data. RESULT: Seven known compounds were isolated and identified as: myricetin (1), myricitrin (2), syringetin-3-O-beta-D-glucopyranoside (3), medioresinol (4), D-1-O-methyl-myo-inositol (5), hydroquinone (6), and beta-sitosterol (7). CONCLUSION: All of these compounds were isolated from genus Heliciopsis for the first time.
Asunto(s)
Proteaceae/química , Flavonoides/química , Flavonoides/aislamiento & purificación , Hidroquinonas/química , Hidroquinonas/aislamiento & purificación , Espectroscopía de Resonancia Magnética , Hojas de la Planta/química , Sitoesteroles/química , Sitoesteroles/aislamiento & purificaciónRESUMEN
Two new 7,6'-coupled naphthylisoquinolines, namely ancistrotectorines A (1) and B (2), two new 5,3'-coupled naphthylisoquinolines, namely ancistrotectorines C (3) and D (4), and one new 7,8-coupled naphthylisoquinoline, namely ancistrotectorine E (5), together with 9 known naphthylisoquinoline alkaloids, hamatine (6), ancistrobertsonine B (7), ancistrocladinine (8), hamatinine (9), ancistrotanzanine A (10), ancistrotanzanine B (11), ancistrotectoriline B (12), 7-epi-ancistrobrevine D (13), and ancistrotectorine (14), were isolated from the 70% EtOH extract of Ancistrocladus tectorius. Their structures were elucidated based on the extensive analysis of spectroscopic data (1D, 2D NMR and MS). Compound 5 exhibited inhibitory activities against HL-60, K562 and U937 cell lines with IC50 values of 1.70, 4.18 and 2.56 µM respectively.
Asunto(s)
Isoquinolinas/aislamiento & purificación , Leucemia/tratamiento farmacológico , Magnoliopsida/química , Naftoles/uso terapéutico , Antineoplásicos Fitogénicos/química , Antineoplásicos Fitogénicos/aislamiento & purificación , Antineoplásicos Fitogénicos/farmacología , Antineoplásicos Fitogénicos/uso terapéutico , Células HL-60 , Humanos , Concentración 50 Inhibidora , Isoquinolinas/química , Isoquinolinas/farmacología , Células K562 , Estructura Molecular , Naftoles/química , Naftoles/aislamiento & purificación , Naftoles/farmacología , Fitoterapia , Extractos Vegetales/química , Extractos Vegetales/farmacología , Extractos Vegetales/uso terapéutico , Hojas de la Planta/química , Tallos de la Planta/química , Células U937RESUMEN
Two new phenylpropionic acid derivates, cerberic acids A (1) and B (2), were isolated from the bark of Cerbera manghas. Their structures were established on the basis of spectroscopic methods including IR, ESI-FT-ICR-MS, 1D and 2D NMR. Primary bioassays showed that compound 1 possessed weak cytotoxic activity against HepG2, MCF-7, and HeLa cell lines with IC(50) values of 44.7, 52.3, 48.7 µg/ml, respectively.