Deep Siamese domain adaptation convolutional neural network-based quaternion fractional order Meixner moments fostered big data analytical method for enhancing cloud data security.

In this paper, Quaternion Fractional Order Meixner Moments-based Deep Siamese Domain Adaptation Convolutional Neural Network-based Big Data Analytical Technique is proposed for improving Cloud Data Security (DSDA-CNN-QFOMM-BD-CDS). The proposed methodology comprises six phases: data collection, transmission, pre-processing, storage, analysis, and security of data. Big data analysis methodologies start with the data collection phase. Deep Siamese domain adaptation convolutional Neural Network (DSDA-CNN) is applied to categorize the types of attacks in the cloud database during the data analysis process. During data security phase, Quaternion Fractional Order Meixner Moments (QFOMM) is employed to protect the cloud data for encryption with decryption. The proposed method is implemented in JAVA and assessed using performance metrics, including precision, sensitivity, accuracy, recall, specificity, f-measure, computational complexity information loss, compression ratio, throughput, encryption time, decryption time. The performance of the proposed method offers 23.31%, 15.64%, 18.89% better accuracy and 36.69%, 17.25%, 19.96% less information loss. When compared to existing methods like Fractional order discrete Tchebyshev encryption fostered big data analytical model to maximize the safety of cloud data depend on Enhanced Elman spike neural network (EESNN-FrDTM-BD-CDS), an innovative scheme architecture for safe authentication along data sharing in cloud enabled Big data Environment (LZMA-DBSCAN-BD-CDS).

Antibacterial, antibiofilm and anti-quorum sensing activities of Muntingia calabura L. leaf extract against Pseudomonas aeruginosa.

The aim of this study was to evaluate the phytochemicals, antioxidant, antibacterial and anti-quorum sensing (QS) properties of methanol extract of Muntingia calabura L. leaves against biofilm-forming strain Pseudomonas aeruginosa. The antioxidant potential of M. calabura methanol leaf extract was evaluated using a radical scavenging assay. Since the findings were so promising, the study aims to screen the phytochemical profiles using qualitative and quantitative approaches and to expand the investigation to anti-QS activity. The antibacterial activity was assessed by determining the minimum inhibitory concentration against pathogenic Gram-negative and Gram-positive biofilm-forming bacterial strains using an agar well diffusion plate method. Muntingia calabura methanol leaf extract was most potent against P. aeruginosa. The QS controlled virulence factors in P. aeruginosa is significantly inhibited by M. calabura leaf extract. The microscopy images revealed a major reduction in P. aeruginosa biofilm formation. Interestingly, M. calabura leaf extract was not toxic to Vero cell line. These findings make M. calabura a strong candidate for new antimicrobial and anti-QS herbal agents.

PEGylation in Pharmaceutical Development: Current Status and Emerging Trends in Macromolecular and Immunotherapeutic Drugs.

The purpose of the research is to examine the advantages and difficulties of target-site drug delivery methods, with an emphasis on the application of polyethylene glycol (PEG) to enhance drug solubility, bioavailability, and immune response characteristics. It has been demonstrated that this method lowers immunogenicity, enhances pharmacokinetics, and helps drugs pass the blood-brain barrier while reducing reticuloendothelial system clearance. PEG and its derivatives are being used more and more to alter therapeutic substances, offering an escape from some of the drawbacks of conventional medication formulations. In the review, different PEGylation tactics are examined, including cutting-edge methods for reversing multi-drug resistance in nanocarriers. PEGylation has a number of benefits, but there are still drawbacks, including the immunogenic reaction to PEG, which is sometimes referred to as "anti-PEG antibodies," and stability problems that call for the creation of countermeasures. The study devotes a large amount of its space to listing FDA-approved PEGylated medications, emphasizing their therapeutic advantages and clinical uses in a range of medical specialties. The research also explores the regulatory environment that surrounds PEG, closely examining its effectiveness and safety in medication compositions. The review goes beyond PEGylation and includes lipid-based nanocarriers, including liposomes, nanostructured lipid carriers (NLCs), and solid lipid nanoparticles (SLNs). Because these nanocarriers can target specific tissues or cells, improve bioavailability, and encapsulate pharmaceuticals, they are becoming more and more significant in drug delivery systems. The Target Product Profile (TPP) and Quality by Design (QbD) principles serve as the foundation for the creation and characterization of these lipid-based systems. These tools direct the methodical assessment of material properties and risk assessments during the formulation phase. This method guarantees that the finished product satisfies the appropriate requirements for efficacy, safety, and quality. The regulatory status and safety profile of nano lipid carriers are covered in the paper's conclusion, which emphasizes the importance of careful examination and oversight in bringing these cutting-edge products to market. Overall, this thorough analysis highlights the revolutionary potential of lipid-based nanocarriers and PEGylation in improving drug delivery and therapeutic efficacy, but it also draws attention to the continued difficulties and legal issues that need to be resolved in order to fully reap the benefits of these technologies in biomedicine.

Robotic percutaneous coronary intervention (R-PCI): Time to focus on the pros and cons.

AIM: To assess the safety, efficiency, and device compatibility of the Second Generation Robotic System. METHODS: Data on Robot-Assisted PCI (R-PCI) is frequently insufficient in India. Many articles were published in national, non-indexed journals that are not available online and are difficult to obtain. Recognizing these constraints, the current review is intended to compile the available data on this important new innovation technique. This review could encourage future research and serve as a valuable source of information. RESULTS/CONCLUSION: In terms of procedure efficiency, operator radiation reduction, and safety, the recent implementation and development of second-generation robotic systems have had a significant impact on interventional cardiology. This technology will play a significant role in the future of interventional cardiology as advancements eliminate the need for manual assistance, improve devices compatibility, and expand the use of robotics for telestenting procedures. A larger study demonstrating the safety and feasibility of tele-stenting over greater geographic distances, as well as addressing fundamental technical difficulties, would be required before attempting R-PCI.

Evaluation of glycemic status among hypercholesterolemic patients on atorvastatin in a tertiary care hospital - A retrospective study.

INTRODUCTION: Statins are effective in reducing low-density lipoprotein cholesterol and are favorable in primary and secondary prevention of cardiovascular disease. Recent large trials have linked the use of statins and increased incidence of new-onset diabetes mellitus, the possibility of worsening of glucose level in individuals with diabetes following statin therapy, and this possibility is increased with the use of atorvastatin. This study was undertaken to analyze the possibility of the diabetogenic potential of atorvastatin among hypercholesterolemic patients. MATERIALS AND METHODS: This retrospective cohort study was conducted in the cardiology department from July 2019 to December 2019. Patients on atorvastatin for more than 6 months with normoglycemia on commencement of therapy were included. The occurrence of prediabetes or new-onset diabetes mellitus after atorvastatin therapy is the outcome of the study. Adverse drug effects to atorvastatin were also recorded and WHO-UMC causality assessment was performed. Descriptive statistics were performed for baseline and demographic characteristics. RESULTS: Sixty study participants were included in the study. Eighteen (30%) study participants developed prediabetes with an HbA1c value of 5.97 ± 0.22 and 17 (28%) of participants developed new-onset diabetes mellitus with an HbA1c value of 7.24 ± 0.50. Atorvastatin at dose of 40 mg was found to be the most frequently prescribed dose. CONCLUSION: Atorvastatin has a dose-dependent risk of developing new-onset diabetes mellitus. Hence, the following statin therapy glycemic status should be periodically monitored especially in patients with a large dose of atorvastatin and also in patients with higher risk factors for diabetes.

Synthesis, spectroscopic, DFT, and molecular docking studies on 1,4-dihydropyridine derivative compounds: a combined experimental and theoretical study.

Dihydropyridines are the most extensively used drugs in the treatment of hypertension. Nifedipine is the prototype of calcium channel blocker. The dihydropyridine derivative compounds of diethyl 4-(4-bromophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate (DHPB), diethyl 4-(furan-2yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate (DHPF), and diethyl-4-phenyl-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate (DHPP) were synthesized using the Hantzsch reaction. The DFT/B3LYP exchange-correlation function was employed to perform quantum chemical calculations such as molecular geometry optimization, vibrational analysis, frontier molecular orbital (FMO), molecular electrostatic potential (MEP), natural bond order (NBO), global reactive descriptors, and Fukui functions to determine the structural characteristics related to biological activity of the compounds. The molecular docking and molecular dynamics were employed to study the binding interaction and stability of protein-ligand complex in the docked site.

Quinoline based reversible fluorescent probe for Pb2+; applications in milk, bioimaging and INHIBIT molecular logic gate.

We report the modular design and synthesis of an amine dangled Schiff base quinoline-morpholine conjugate (QMC) for highly selective detection of Pb2+ ions via fluorimetry. The sensing strategy of QMC towards Pb2+ ion exhibits a large blue shift with fluorescent enhancement via the intramolecular charge transfer (ICT) process. At the same time, QMC coordination with Pb2+, the CN single bond rotation between quinoline and morpholine rings and the CN isomerization process were blocked. Best of our knowledge, this is the first blue shifted turn-on fluorescent chemosensor for Pb2+ ion via the ICT process. Furthermore, QMC selectively detects Pb2+ ion without any interference with alkali, alkaline earth, and transition metal ions, and limit of detection (LOD) downs to 13 µM, which is a permissible level of Pb2+ ion in drinking water reported by WHO. The 1:2 binding stoichiometry between QMC and Pb2+ was confirmed by fluorimetric, 1H NMR titration, mass spectrometry, and theoretical studies. Finally, QMC was potentially applied for the sensing of Pb2+ ions in milk, red wine, live cells and an INHIBIT molecular logic function was constructed by using Pb2+ and EDTA as chemical inputs.

Review of phenotypic markers used in flow cytometric analysis of MGUS and MM, and applicability of flow cytometry in other plasma cell disorders.

Flow cytometric immunophenotyping is considered an indispensable tool for the diagnosis, classification and monitoring of disease in monoclonal gammopathies. The clinical sensitivity of flow cytometry is comparable with advanced molecular methods. Clinical application of flow cytometry in monoclonal gammopathies has various dimensions, such as differential diagnosis of malignant plasma cell disorder from reactive plasmacytosis, identifying the progression risk in monoclonal gammopathy of undetermined significance (MGUS) and asymptomatic multiple myeloma (MM), and minimal residual disease detection. Flow cytometry-based clonality assessment with immunophenotyping encourages and enables the most stringent method of diagnosis and follow-up. The objective of this review is to update the malignant plasma cells phenotypic profile of MGUS and MM. The most comprehensive antigens, such as CD19, CD27, CD28, CD45, CD56 and CD117, play a significant role in the characterization of normal and malignant plasma cells. Several research groups described the putative phenotype of myeloma cell progenitors, but no remarkable suggestion could be made because of disparity. This review also focuses on the association of malignant phenotypic markers and chromosomal aberrations that identify the specific prognostic features in monoclonal gammopathies.

Sb nanoparticle decorated rGO as a new anode material in aqueous chloride ion batteries.

An aqueous chloride ion battery (CIB) is an emerging technology for electrochemical energy storage as well as battery desalination systems. However, the instability and decomposition of electrode materials in an aqueous medium is a major issue in CIBs. Herein, in one step, we synthesized fine antimony nanoparticles with a size of ∼20 nm on reduced graphene oxide (Sb@rGO) sheets using a hydrothermal route with facile and cost-effective processes. It is proposed as a new anode material and coupled with the AgCl cathode in an aqueous CIB. The specific capacity is maintained constantly at 51.6 mA h g-1 at a current density of 400 mA g-1 even after 200 cycles. In addition, characterization methods such as electrochemical analysis, X-ray diffraction, etc. were used to confirm the reaction mechanism. The chloride ion capture material developed in this research work will be significant for CIBs as an energy storage technology or battery desalination system.

Workplace based Potentially Malignant Oral Lesions Screening among Tobacco Consuming Migrant Construction Site Workers in Chennai, South India: A Pilot Study.

CONTEXT: Vulnerable population groups such as migrant workers are identified as emerging high-risk groups for oral cancer owing to the high prevalence of smokeless tobacco consumption. Premature deaths due to oral cancer can be prevented by screening the population with high tobacco consumption practices and detecting early reversible stages of oral mucosal cavity lesions and facilitating linkages for further care. AIM: To assess prevalence of potentially malignant oral mucosal cavity lesions among tobacco consuming migrant construction workers in sub-urban Chennai, India. SETTINGS AND DESIGNS: A workplace based cross-sectional study design. MATERIALS AND METHODS: A cross-sectional study was conducted at workplaces i.e., construction sites for screening potentially malignant oral mucosal cavity lesions among migrant workers across 23 construction sites of Chennai during September 2019 - February 2020. An onsite, group health education session was provided about the harms of tobacco use to the migrants. STATISTICAL ANALYSIS USED: Data entered in MS Excel was analysed using SPSS and multivariate analysis was performed. RESULTS: Among 640 migrants included in the study, 411 (64.2%) were less than 30 years of age, 623 (97.4%) were from north-eastern states of India such as West Bengal, Bihar, Rajasthan, Uttar Pradesh, Jharkhand. A considerable size (272, 42.5%) could not read or write and 355 (55.4%) earn a monthly income of less than ten thousand rupees. Current tobacco users were 619 (96.7%), smokeless tobacco users (463, 72.34%), smokers (206, 32.2%) and dual users (52,8.12%). Inflammatory mucosal lesions in the oral cavity were 70.97% and more among smokeless tobacco users comparable to 22.58% among tobacco smokers and was significantly associated with up to 20 years of tobacco consumption. CONCLUSIONS: Prevalence of Potentially malignant oral lesions among smokeless tobacco using interstate migrant construction site workers is very high and need urgent interventions.

Understanding the enhanced electrical properties of free-standing graphene paper: the synergistic effect of iodide adsorption into graphene.

Free-standing graphene (FSG) paper plays a vital role in a wide variety of applications as an electrode material. Specifically, the electrical properties of FSG are the most important factor affecting its use as an electrode material. Herein, the vacuum filtration technique is utilized to fabricate GO paper, which is then reductively treated with HI. Initially, the electrical conductivity is measured for GO papers with different thicknesses by varying the concentration of GO precursor as well as the reduction time. The FSG paper with a thickness of 3 microns exhibits the lowest sheet resistance and further characterization is carried out to reveal the origin of this enhancement of electrical properties. The low resistance is attributed to its crystalline nature, stacking height (L c), in-plane crystallite size (L a) and defect density (n D). Meanwhile, iodide ions intercalated into the graphene layers act as hole-carriers, and their intercalation is favoured over adsorption at the surface.

Free-standing graphene/NiMoS paper as cathode for quasi-solid state dye-sensitized solar cells.

Highly catalytic two dimensional and metal-doped two-dimensional nanomaterials (MoS2 and NiMoS) were deposited over free-standing graphene (FSG) paper using electrodeposition method and subsequently used as a counter electrode in quasi solid-state dye-sensitized solar cells (q-DSSCs). The replacement of FTO by FSG facilitates high electrical conductivity and electrodeposited metal sulphides provide electrocatalytic activity. The morphology, structural phase formation and chemical composition of FSG-MoS2 and FSG-NiMoS were investigated using FESEM, XRD, Raman and XPS analysis. The electrochemical behavior of metal sulphide decorated FSG cathodes is investigated using an electrochemical workstation and their effects on the photo-conversion efficiency of DSSCs were assessed. NiMoS with FSG substrate is an intriguing counter electrode material that can be utilized at low fabrication cost than the conventional platinum-based counter electrodes. FSG along with the metallic-two dimensional nanoparticles (NiMoS) functions as an effective catalytic material thereby allowing DSSCs to achieve enhanced efficiency of ∼7% to provide better alternative of FTO and Pt.

Difficulties encountered in preauricular approach over retromandibular approach in condylar fracture.

Fracture of mandible can be classified according to its anatomical location, in which condylar fracture is the most common one overall and is missed on clinical examination. Due to the unique geometry of the mandible and temporomandibular joint, without treatment the fractures can result in marked pain, dysfunction, and deformity. The condylar fracture may be further classified depending on the sides involved: unilateral/bilateral, depending on the height of fracture: intracapsular (within the head of condyle), extracapsular - head and neck (high condyle fracture), and subcondylar (low condyle fracture), and depending on displacement: nondisplaced, displaced (anteromedially, medially, and lateral), and dislocated. The clinical features include swelling and tenderness over the temporomandibular joint region, restricted mouth opening, and anterior open bite. A 34-year-old male patient reported to the Department of Oral and Maxillofacial Surgery at Madha Dental College and Hospital; suffered fall trauma resulting in bilateral condyle fracture, dentoalveolar fracture in mandible with restricted mouth opening, and anterior open bite.

Fibrous dysplasia-recent concepts.

Fibrous dysplasia (FD) is a benign intramedullary fibro-osseous lesion. FD is a bone developmental anomaly characterized by replacement of normal bone and marrow bone by fibrous tissue. It involves any of the bones as single lesion (monostotic) or in multiple bone lesions (polyostotic) or all of the skeletal system (panostotic). Long bones are most commonly involved, which mostly identified incidentally and clinically appears asymptomatic. Clinical, radiographical and histopathological findings will help in confirming the lesion. There are many treatment option available, but still management of FD remains challenging.

Stable colloidal dispersion of functionalized reduced graphene oxide in aqueous medium for transparent conductive film.

We prepared stable colloidal suspension graphene in aqueous medium by surface modification of graphene with 4-benzenediazonium sulfonate. The sulfonate group on graphene surface interacts with water, exhibits well dispersibility and which prevents the aggregation even at neutral pH. This dispersion shows stability for three months and facile to produce films. Using such a modified graphene dispersion, transparent conductive film (TCF) has been fabricated on glass substrate by spin coating method. At appropriate concentration, the film exhibits an excellent optoelectrical property with resistivity of 1.1 kΩ with the transparency of 89% at the wavelength of 550 nm. Further, we also demonstrated the mechanical, thermal, and optoelectrical properties of prepared films.