Detalles de la búsqueda
1.
Normalizing granuloma vasculature and matrix improves drug delivery and reduces bacterial burden in tuberculosis-infected rabbits.
Proc Natl Acad Sci U S A
; 121(14): e2321336121, 2024 Apr 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-38530888
2.
A preclinical model of TB meningitis to determine drug penetration and activity at the sites of disease.
Antimicrob Agents Chemother
; 67(12): e0067123, 2023 12 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-37966227
3.
Lung microenvironments harbor Mycobacterium tuberculosis phenotypes with distinct treatment responses.
Antimicrob Agents Chemother
; 67(9): e0028423, 2023 09 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-37565762
4.
Drug distribution and efficacy of the DprE1 inhibitor BTZ-043 in the C3HeB/FeJ mouse tuberculosis model.
Antimicrob Agents Chemother
; 67(11): e0059723, 2023 11 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-37791784
5.
A Rabbit Model to Study Antibiotic Penetration at the Site of Infection for Nontuberculous Mycobacterial Lung Disease: Macrolide Case Study.
Antimicrob Agents Chemother
; 66(3): e0221221, 2022 03 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-35099272
6.
Colocation of Lipids, Drugs, and Metal Biomarkers Using Spatially Resolved Lipidomics with Elemental Mapping.
Anal Chem
; 94(34): 11798-11806, 2022 08 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-35981335
7.
Spatial quantitation of antibiotics in bone tissue compartments by laser-capture microdissection coupled with UHPLC-tandem mass spectrometry.
Anal Bioanal Chem
; 414(23): 6919-6927, 2022 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-35945288
8.
Lesion Penetration and Activity Limit the Utility of Second-Line Injectable Agents in Pulmonary Tuberculosis.
Antimicrob Agents Chemother
; 65(10): e0050621, 2021 09 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-34252307
9.
Pharmacokinetics and Target Attainment of SQ109 in Plasma and Human-Like Tuberculosis Lesions in Rabbits.
Antimicrob Agents Chemother
; 65(9): e0002421, 2021 08 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-34228540
10.
Comparative Analysis of Pharmacodynamics in the C3HeB/FeJ Mouse Tuberculosis Model for DprE1 Inhibitors TBA-7371, PBTZ169, and OPC-167832.
Antimicrob Agents Chemother
; 65(11): e0058321, 2021 10 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-34370580
11.
Correlative Imaging of Trace Elements and Intact Molecular Species in a Single-Tissue Sample at the 50 µm Scale.
Anal Chem
; 93(40): 13450-13458, 2021 10 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-34597513
12.
Tissue Distribution of Doxycycline in Animal Models of Tuberculosis.
Antimicrob Agents Chemother
; 64(5)2020 04 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-32041718
13.
Matrix metalloproteinase inhibitors enhance the efficacy of frontline drugs against Mycobacterium tuberculosis.
PLoS Pathog
; 14(4): e1006974, 2018 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-29698476
14.
Fluoroquinolone Efficacy against Tuberculosis Is Driven by Penetration into Lesions and Activity against Resident Bacterial Populations.
Antimicrob Agents Chemother
; 63(5)2019 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-30803965
15.
Whole-Cell Screen of Fragment Library Identifies Gut Microbiota Metabolite Indole Propionic Acid as Antitubercular.
Antimicrob Agents Chemother
; 62(3)2018 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-29229639
16.
Ethambutol Partitioning in Tuberculous Pulmonary Lesions Explains Its Clinical Efficacy.
Antimicrob Agents Chemother
; 61(9)2017 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-28696241
17.
Selective Inactivity of Pyrazinamide against Tuberculosis in C3HeB/FeJ Mice Is Best Explained by Neutral pH of Caseum.
Antimicrob Agents Chemother
; 60(2): 735-43, 2016 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-26574016
18.
Mtb-Selective 5-Aminomethyl Oxazolidinone Prodrugs: Robust Potency and Potential Liabilities.
ACS Infect Dis
; 10(5): 1679-1695, 2024 May 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-38581700
19.
On-Slide Heat Sterilization Enables Mass Spectrometry Imaging of Tissue Infected with High-Threat Pathogens Outside of Biocontainment: A Study Directed at Mycobacterium tuberculosis.
J Am Soc Mass Spectrom
; 32(11): 2664-2674, 2021 Nov 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-34672552
20.
Pyrazinoic Acid Inhibits Mycobacterial Coenzyme A Biosynthesis by Binding to Aspartate Decarboxylase PanD.
ACS Infect Dis
; 3(11): 807-819, 2017 11 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-28991455