Asunto(s)
Antígenos CD1/genética , Células de Langerhans/inmunología , Mutación Puntual/genética , Adulto , Células Presentadoras de Antígenos/inmunología , Células Presentadoras de Antígenos/patología , Biopsia , Línea Celular , Línea Celular Tumoral , Epidermis/inmunología , Epidermis/patología , Femenino , Células HEK293 , Antígenos HLA-DR/genética , Humanos , Células K562 , Células de Langerhans/patología , Masculino , Persona de Mediana Edad , Piel/inmunología , Piel/patología , Adulto JovenRESUMEN
Dengue is endemic in tropical countries worldwide and the four dengue virus serotypes often co-circulate. Infection with one serotype results in high titers of cross-reactive antibodies produced by plasmablasts, protecting temporarily against all serotypes, but impairing protective immunity in subsequent infections. To understand the development of these plasmablasts, we analyzed virus-specific B cell properties in patients during acute disease and at convalescence. Plasmablasts were unrelated to classical memory cells expanding in the blood during early recovery. We propose that only a small subset of memory B cells is activated as plasmablasts during repeat infection and that plasmablast responses are not representative of the memory B cell repertoire after dengue infection.