RESUMEN
We reviewed MRI and SPECT images in 10 patients with septo-optic dysplasia (SOD). MRI was performed in all of them. Six of them had bilateral optic nerve atrophy and abnormality of midline brain structures (e. g., septum pellucidum, corpus callosum). Four cases had one-sided optic nerve atrophy. They have ipsilateral or bilateral cortical dysplasia. It may suggest that one of the pathogenesis of SOD is a disruption of the anterior cerebral artery at embryonic site. SPECT was performed in 3 patients with cortical dysplasia. At cortical dysplasia area, CBF-SPECT and IMZ-SPECT showed the same RI count as the normal cortex. This finding is compatible with the fact that few patients with SOD have epileptic seizures.
Asunto(s)
Displasia Septo-Óptica/diagnóstico , Adolescente , Niño , Preescolar , Femenino , Humanos , Imagen por Resonancia Magnética , Masculino , Tomografía Computarizada de Emisión de Fotón ÚnicoRESUMEN
We reviewed the efficacy and a pharmacokinetics of intranasal midazolam (MDL) for status epilepticus in childhood epilepsies. This trial was planned for the patients who developed status epilepticus at least once in the past and had no responses with diazepam. Intranasal midazolam was proved to be effective (complete remission;65%), rapidly (an average time to stop seizures; 5.7 min) and safe with no adverse effects including respiratory depression with this dosage (an average of 0.26 mg/kg). In patients whose longitudinal concentrations of MDL in the blood were measured, MDL level was increased rapidly within five minutes after nasal application. Intranasal MDL is useful as a simple and safe method in the child emergency situation.