RESUMEN
Non-compaction of the ventricular myocardium (NCM) is a genetic cardiomyopathy usually due to mutationof the G4.5 gene located in the Xq28 chromosomal region. This congenital disorder is characterized by pronounced trabeculations and intertrabecular recesses resulting from abnormal embryogenesis between the fifth and eighth fetal weeks. The reported prevalence in the general population is between 0.014% and 1.3%. The classic triad of complications includes heart failure, ventricular arrhythmias and systemic embolic events, although some patients have an asymptomatic form. NCM is commonly diagnosed by echocardiography, but contrast ventriculography, CT and MRI can also be used. Here we present a case of left ventricle NCM, manifested after respiratory infection, in a pregnant patient with congenital thrombophilia and a history of myocardial infarction. LEARNING POINTS: Non-compaction myocardium (NCM) in pregnant women has been associated with a poor prognosis.We should avoid routinely recommending young women with NCM to refuse pregnancy.A decision to continue pregnancy should be made by the patient in discussion with specialists.
RESUMEN
Acute myocardial infarction is still considered as one of the most threatening disorders in internal medicine. Numerous complications of infarction develop due to activation of different neurohumoral systems. The article discusses modern methods of pharmacological correction of neurohumoral system activity in various stages of myocardial infarction. It is emphasized that current guidelines do not always allow to effectively prevent left ventricular remodeling. New drugs used for this aim are discussed.