Liver organoids: established tools for disease modeling and drug development.

In the past decade, liver organoids have evolved rapidly as valuable research tools, providing novel insights into almost all types of liver diseases, including monogenic liver diseases, alcohol-associated liver disease, metabolic-associated fatty liver disease, various types of (viral) hepatitis, and liver cancers. Liver organoids in part mimic the microphysiology of the human liver and fill a gap in high-fidelity liver disease models to a certain extent. They hold great promise to elucidate the pathogenic mechanism of a diversity of liver diseases and play a crucial role in drug development. Moreover, it is challenging but opportunistic to apply liver organoids for tailored therapies of various liver diseases. The establishment, applications, and challenges of different types of liver organoids, for example, derived from embryonic, adult, or induced pluripotent stem cells, to model different liver diseases, are presented in this review.

[New method for wave-plate orientation determination based on the shape of the modulated spectrum].

A new method for the determination of fast axis of wave-plate is introduced. Based on the principle of electro-optic phase compensation in the wave-plate phase measuring method, the relation between the polarization extinction system out-put signal and the modulating signal can be acquired through the composition of frequency fixed alternating voltage modulation signal. Through the analysis of this process with Jones matrix, the out-put signal was usually found to be the composition of fundamental frequency and second harmonic frequency, the composition signal reflects the axis information as well as the phase information of the wave-plate, and this phenomenon has never been noticed before. Through the analysis of this phenomenon, the transformation trends of the composed wave-form by rotating of wave-plates with different orientations were deduced, and through the observation of the transformation trend, one can easily distinguish the fast and slow axes of wave-plates with phase retardation > pi as well as those with phase retardation < pi, and their phenomena are reverse to each other.