Rattle-Structured Upconversion Nanoparticles for Near-IR-Induced Suppression of Alzheimer's ß-Amyloid Aggregation.

Rose bengal (RB)-loaded upconverting nanocomposites are synthesized as a near-infrared (NIR)-responsive inhibitor of Aß aggregation. Rattle-structured, organosilica shell (ROS) is deposited on NaYF4 :Yb,Er nanocrystals (UCNPs) for high loading efficiency and disaggregation of RB. RB/UCNP@ROS successfully inhibits Aß self-assembly under NIR irradiation by generating 1 O2 . Furthermore, photoexcited RB/UCNP@ROS is effective in suppressing Aß-induced cytotoxicity.