RESUMEN
Subcutaneous panniculitis-like T-cell lymphoma is a cutaneous lymphoma characterized by CD8+ T-cell infiltrate in the subcutis that is rare in children. Acute lymphoblastic lymphoma is the most common pediatric malignancy and often presents with fevers and pancytopenia. Herein, we report 2 pediatric patients presenting with subcutaneous panniculitis-like T-cell lymphoma and B-cell acute lymphoblastic lymphoma, distinct hematologic malignancies arising from different lymphoid lineages, with no identifiable germline cancer predisposition.
Asunto(s)
Linfoma de Células T/complicaciones , Paniculitis/complicaciones , Leucemia-Linfoma Linfoblástico de Células Precursoras B/complicaciones , Linfocitos B/patología , Linfocitos T CD8-positivos/patología , Preescolar , Femenino , Humanos , Linfoma de Células T/diagnóstico , Linfoma de Células T/patología , Masculino , Paniculitis/diagnóstico , Paniculitis/patología , Leucemia-Linfoma Linfoblástico de Células Precursoras B/diagnóstico , Leucemia-Linfoma Linfoblástico de Células Precursoras B/patologíaRESUMEN
Sclerodermatous graft-versus-host disease is a subtype of cutaneous chronic graft-versus-host disease that is characterized by sclerosis of the skin and subcutaneous tissue, resulting in debilitating contractures, among other life-threatening complications. Children with sclerodermatous graft-versus-host disease are at high risk of developing nonmelanoma skin cancer because of several risk factors, including young age at transplantation, prolonged immunosuppression, and exposure to photosensitizing antimicrobial prophylaxis such as voriconazole. The immunosuppression required to treat sclerodermatous graft-versus-host disease makes effectively treating nonmelanoma skin cancer and sclerodermatous graft-versus-host disease in the same patient challenging. We describe a challenging case of a 6-year-old boy with a history of sclerodermatous graft-versus-host disease and voriconazole exposure presenting with squamous cell carcinoma in situ on the left temple and actinic keratoses on the scalp treated with topical chemotherapy agents.
Asunto(s)
Antifúngicos/efectos adversos , Carcinoma de Células Escamosas/etiología , Enfermedad Injerto contra Huésped/complicaciones , Neoplasias Cutáneas/etiología , Voriconazol/efectos adversos , Administración Tópica , Antifúngicos/uso terapéutico , Trasplante de Médula Ósea/efectos adversos , Carcinoma de Células Escamosas/tratamiento farmacológico , Carcinoma de Células Escamosas/cirugía , Dermatitis Fototóxica/complicaciones , Fluorouracilo/administración & dosificación , Enfermedad Injerto contra Huésped/tratamiento farmacológico , Humanos , Inmunosupresores/efectos adversos , Inmunosupresores/uso terapéutico , Queratosis Actínica/tratamiento farmacológico , Queratosis Actínica/etiología , Masculino , Piel/patología , Neoplasias Cutáneas/tratamiento farmacológico , Voriconazol/uso terapéuticoRESUMEN
Numerous disorders present with vesiculopustular eruptions in the neonatal period, ranging from benign to life-threatening. Accurate and prompt diagnosis is imperative to avoid unnecessary testing and treatment for benign eruptions, while allowing for adequate treatment of potentially fatal disorders. In this review, we highlight several rare blistering diseases of the newborn. A diagnostic approach is outlined to provide clinicians with a framework for approaching a neonate with vesicles, pustules, or ulcers.