Revisiting frequencies of phonological sound classes in speech input: Change over time in child-directed speech.

The purpose of the current study was to revisit a controversial topic: whether frequencies of phonological consonant and vowel classes differ in speech directed to children and to adults. In addition, the current study investigated whether the frequency of phonological consonant and vowel classes changes with children's increasing chronological and/or developmental age. This study analyzed speech input from 44 adults to four different age groups of listeners (i.e., three groups of children at 6, 18, and 36 months of age and one group of adult listeners) in terms of frequency of occurrence of consonant and vowel classes. Results revealed that consonant stop, nasal, fricative and glide manner classes as well as all four consonant place classes were significantly different in speech directed to the four different age groups. A perspective is discussed to better understand the nature of frequency input of phonological sound classes.

English Nasalance Values of Chinese Learners of English.

INTRODUCTION: Although a number of studies have been conducted to investigate nasalance scores of speakers of different languages, little research has examined the nasalance characteristics of second language learners. OBJECTIVE: The goal of the current study was to examine whether English nasalance values of Mandarin Chinese speakers are similar to those of native English speakers, examining the potential effect of the first language on the nasalance scores of the second language production. METHODS: Thirty-two adults (16 Mandarin Chinese speakers and 16 native English speakers) with a normal velopharyngeal anatomy participated. Nasalance scores of various speech stimuli were obtained using a nasometer and compared between the 2 groups. RESULTS AND CONCLUSIONS: Chinese learners of English produced higher nasalance scores than native English speakers on prolonged vowel /i/ and /a/, the syllable "nin," and non-nasal sentences and passages. The first language effect on nasalance of the second language found in the current study suggests the importance of linguistic consideration in the clinical evaluation of resonance.

Use of ultrasound visual feedback in speech intervention for children with cochlear implants.

The purpose of the present study was to evaluate the efficacy of ultrasound visual feedback in speech intervention for young children with cochlear implants. Although ultrasound technology has been used for intervention in children with speech sound disorders, there is little systematic evidence regarding relative efficacy of ultrasound visual feedback for young children with cochlear implants. Two children with cochlear implants participated in this study. The children's articulation was tested using Goldman-Fristoe Test of Articulation-2 and probes. Therapy was provided semi-weekly for 30-minute sessions over the course of nine to 10 weeks. Visual inspection showed an increasing trend in production accuracy to the criterion accuracy of 80% for target sounds. Maintenance of skills were observed at two weeks and two months post-intervention. The results of this study indicated that ultrasound visual feedback is likely an effective intervention tool for treating speech sound disorders in children with cochlear implants. Future studies including a larger sample size should be conducted to verify these findings.

Differences in nasalance and nasality perception between Texas South and Midland dialects.

While previous research has primarily concerned the dialectal influence on speakers' production of oral-nasal balance, quantitatively represented by nasalance, information on cross-dialectal variation in nasality perception is limited. This study investigated the effects of speakers'/listeners' dialectal background on oral-nasal balance characteristics estimated by nasalance, as well as nasality perception measured by direct magnitude estimation with modulus. Represented by two geographically distinct regions, Texas South and Midland dialects were of special interest given that the two dialects lie at opposite ends of normal nasalance variation [Awan, Bressmann, Poburka, Roy, Sharp, and Watts. (2015). J. Speech Lang. Hear. Res. 58, 69-77]. Mean nasalance of various speech stimuli and direct magnitude estimation ratings on synthesized vowel stimuli with varying degrees of simulated nasalization were obtained from 62 participants (31 Texas South, 31 Midland). The results revealed that the two dialectal groups significantly differed in nasalance scores and nasality ratings, with Texas South exhibiting higher nasalance for standardized passage readings and assigning higher nasality ratings on the synthetic auditory stimuli than Midland. These findings indicate that, in addition to production variations of oral-nasal balance characteristics, perceptual variations of nasality exist at a dialectal level.

The emergence of phonetic categories in Korean-English bilingual children.

The present study examined the speech production of three-year-old Korean-English bilingual (KEB) children. English and Korean stops, as well as front vowels in both languages, were compared acoustically among the KEB children, then also measured against those of their age-equivalent monolingual counterparts. Evidence of distinctive phonetic categorization in bilingual children was more salient in vowels than in stops. Vowels and stops produced by the bilingual children were not significantly different from those of their monolingual counterparts. The findings suggest that, similar to other language domains, two linguistic systems are apparent in the phonetic production component of three-year-old KEB children, but that phonetic distinctiveness in production may not emerge holistically in an across-the-board fashion, appearing earlier in vowels than stops. Thus, the phonetic production systems of the two languages may develop with only limited interaction in simultaneous KEB children exposed to two languages at an early age.

Suppression of α-synuclein toxicity and vesicle trafficking defects by phosphorylation at S129 in yeast depends on genetic context.

The aggregation of α-synuclein (αSyn) is a neuropathologic hallmark of Parkinson's disease and other synucleinopathies. In Lewy bodies, αSyn is extensively phosphorylated, predominantly at serine 129 (S129). Recent studies in yeast have shown that, at toxic levels, αSyn disrupts Rab homeostasis, causing an initial endoplasmic reticulum-to-Golgi block that precedes a generalized trafficking collapse. However, whether αSyn phosphorylation modulates trafficking defects has not been evaluated. Here, we show that constitutive expression of αSyn in yeast impairs late-exocytic, early-endocytic and/or recycling trafficking. Although members of the casein kinase I (CKI) family phosphorylate αSyn at S129, they attenuate αSyn toxicity and trafficking defects by an S129 phosphorylation-independent mechanism. Surprisingly, phosphorylation of S129 modulates αSyn toxicity and trafficking defects in a manner strictly determined by genetic background. Abnormal endosome morphology, increased levels of the endosome marker Rab5 and co-localization of mammalian CKI with αSyn aggregates are observed in brain sections from αSyn-overexpressing mice and human synucleinopathies. Our results contribute to evidence that suggests αSyn-induced defects in endocytosis, exocytosis and/or recycling of vesicles involved in these cellular processes might contribute to the pathogenesis of synucleinopathies.

The Correlation Between Perceptual Ratings and Nasalance Scores in Resonance Disorders: A Systematic Review.

INTRODUCTION: Assessment of resonance characteristics is essential in research and clinical practice in individuals with velopharyngeal impairment. The purpose of this study was to systematically review correlations between auditory-perceptual ratings and nasalance scores obtained by a nasometer in individuals with resonance disorders and to identify factors that affected the correlations between these two measures. METHOD: Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, a systematic search was conducted for studies reporting a correlation between nasality ratings and nasalance scores using six electronic databases based on predefined inclusion and exclusion criteria. RESULTS: A total of 27 studies were included in this systematic review. Characteristics of study components including participants, types of assessment and stimuli, correlation coefficients, and reliability values of each study were identified, and a narrative synthesis was conducted. The methodological quality of each study was also appraised. The correlation level between nasalance values and nasality ratings varied from nonsignificant to strong (r = .92). The quality rating scores of the selected studies ranged from 44% to 94%, with an average score of 75%. DISCUSSION: Factors that did or did not affect the varied correlation between nasality ratings and nasalance scores were discussed. Speech stimuli and the listeners' background were associated with correlations between the two measures. In addition, the sex of the speakers could be a factor affecting its correlation. However, the types of perceptual scales and listening conditions did not influence its correlations between the two measures. SUPPLEMENTAL MATERIAL: https://doi.org/10.23641/asha.19653207.

Normative Nasalance Values in Vietnamese With Southern Dialect: Vowel and Tone Effects.

Purpose The purpose of the current study was to examine normative nasalance values in Vietnamese adult speakers with Southern dialect and to investigate the effects of vowels and tones on nasalance. Previous studies examining nasalance have been mainly conducted with Indo-European languages. Limited information on nasalance is available in tone languages other than Chinese. Furthermore, tone and vowel effects on nasalance scores in tone languages have not been fully examined. Method Nasalance scores of various speech stimuli including passages, syllables, and prolonged vowels were obtained from Vietnamese-speaking adults with Southern dialect (M age = 23 years) using a nasometer (KayPENTAX 6450). Results The average nasalance scores of Southern Vietnamese adult speakers were 24.16%, 38.17%, and 70.03% for the oral, oral-nasal, and nasal passages, respectively. Southern Vietnamese speakers produced the highest nasalance scores on the vowel /a/, followed by /i/ and /u/. Nasalance scores of stimuli produced with the falling and restricted tone were significantly lower than those produced with the other tones. Conclusions The normative nasalance values of the current study will contribute as a reference index for the Vietnamese language. The effects of vowels and tones can also provide insight into the development of nasalance testing stimuli and for characterizing nasalance values across languages.

Universal production patterns and ambient language influences in babbling: a cross-linguistic study of Korean- and English-learning infants.

The phonetic characteristics of canonical babbling produced by Korean- and English-learning infants were compared with consonant and vowel frequencies observed in infant-directed speech produced by Korean- and English-speaking mothers. For infant output, babbling samples from six Korean-learning infants were compared with an existing English babbling database (Davis & MacNeilage, 1995). For ambient language comparisons, consonants and vowels in ten Korean and ten English infant-directed speech (IDS) samples were analyzed. The two infant groups demonstrated similar consonant patterns, but showed different vowel patterns from one another. For both languages, infant vowel patterns were related to those of ambient language IDS. Ambient language patterns were manifested in infant vowel output, perhaps because vowels are more perceptually and motorically available in the input and output capacities of babbling infants.

Segmental distribution patterns of English infant- and adult-directed speech.

This study compared segmental distribution patterns for consonants and vowels in English infant-directed speech (IDS) and adult-directed speech (ADS). A previous study of Korean indicated that segmental patterns of IDS differed from ADS patterns (Lee, Davis & MacNeilage, 2008). The aim of the current study was to determine whether such differences in Korean are universal or language-specific. Results indicate that consonant distribution patterns of English IDS were significantly different from English ADS. Speakers who used IDS produced fewer fricatives, affricates, nasals and liquids, but more stops and glides, than speakers who used ADS. In terms of vowels, IDS speakers produced more high-back vowels /u / and /open oI/ diphthongs than ADS speakers. These results indicate both general trends and language-specific segmental distribution patterns in IDS. When compared to previous findings on ADS and IDS in Korean, these results for English give support to a more general assertion that segmental distribution patterns in IDS seem to be mediated by linguistic and cultural factors across languages.

Feasibility of a Supplemental Phonological Awareness Intervention via Telepractice for Children with Hearing Loss: A Preliminary Study.

The goal of the current study was to examine the feasibility of a telepractice intervention to improve phonological awareness skills in children with hearing loss as compared to a conventional in-person intervention. Twenty children with hearing loss participated in this study. Two groups of ten children each received a supplemental phonological awareness intervention either via telepractice or an in-person service delivery model. Within each of the two groups, five children were enrolled in preschool or kindergarten and five children were enrolled in first or second grade. The two groups of children demonstrated similar phonological awareness, non-verbal IQ, and vocabulary skills during pre-tests. After a 12-week intervention children with hearing loss showed improved phonological awareness skills as measured by a standardized post-test. No significant differences were found between the performance of the telepractice group and in-person group. Nor was a significant interaction found between the two age groups (PreK/K vs. 1st /2nd grade) and the two types of service delivery models (in-person vs. telepractice). The results suggest that a telepractice service delivery model is feasible for young children with hearing loss, and that telepractice may be as effective as in-person intervention in improving phonological awareness skills.

The dysfunctional placenta epigenome: causes and consequences.

The placenta is a fetal-maternal endocrine organ responsible for ensuring proper fetal development throughout pregnancy. Adverse insults to the intrauterine environment often lead to expression level changes in placental genes, many of which are epigenetically regulated by DNA methylation, histone modifications and ncRNA interference. These epigenetic alterations may cause placental dysfunction, resulting in offspring of low birthweight owing to adverse pregnancy complications such as intrauterine growth restriction. Numerous epidemiological studies have shown a strong correlation between low birthweight and increased risk of developing metabolic diseases and neurological imbalances in adulthood, and in subsequent generations, indicating that epigenetic regulation of gene expression can be propagated stably with long-term effects on health. This article provides an overview of the various environmental factors capable of inducing detrimental changes to the placental epigenome, as well as the corresponding mechanisms that prime the offspring for onset of disease later in life.

Vowel category formation in Korean-English bilingual children.

PURPOSE: A previous investigation (Lee & Iverson, 2012) found that English and Korean stop categories were fully distinguished by Korean-English bilingual children at 10 years of age but not at 5 years of age. The present study examined vowels produced by Korean-English bilingual children of these same ages to determine whether and when bilinguals establish distinct vowel categories across their 2 languages. METHOD: Both English and Korean vowels produced by 40 Korean-English bilingual children (5 and 10 years of age) were examined in terms of 1st formant frequency (F1) and 2nd formant frequency (F2), vowel duration, and F1 and F2 formant trajectories. RESULTS: Formant frequencies of vowels produced by the bilingual children were similar to those of monolingual English and Korean children. The bilinguals distinguished vowel categories across languages using both the assimilation and dissimilation mechanisms as identified by Flege, Schirru, and MacKay (2003). CONCLUSIONS: Vowel categories developed earlier than stops in bilingual children because vowels were typically acquired earlier than consonants. The results of this study suggest that detailed phonetic categories do not form across the board and that bilingual children may invoke multidimensional representations of phonetic categories.