Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 69
Filtrar
Más filtros

Banco de datos
País/Región como asunto
Tipo del documento
Intervalo de año de publicación
1.
J Sex Med ; 21(8): 716-722, 2024 08 01.
Artículo en Inglés | MEDLINE | ID: mdl-38971577

RESUMEN

BACKGROUND: Peyronie's disease (PD) is a connective tissue disorder that affects the penis and is characterized by abnormal collagen structure in the penile tunica albuginea, resulting in plaque formation and penile deformity. PD's overall prevalence is estimated at 3.2% to 8.9%, with rates as high as 20.3% among men with type 2 diabetes mellitus (DM). However, the characteristics of DM associated with PD complications remain unclear. AIM: To explore clinical associations between DM characteristics and PD complications. METHODS: We conducted a retrospective analysis of patients with DM and PD who presented at our institution between 2007 and 2022. We examined patients' clinical histories, DM- and PD-related clinical parameters, and complications. Penile deformities were assessed through physical examination, photographs, and penile Doppler ultrasound. Patients were categorized into subgroups based on age of DM onset: early (<45 years), average (45-65 years), and late (>65 years). OUTCOMES: Outcomes included effects of DM characteristics on PD development, progression, and severity. RESULTS: In total, 197 patients were included in the evaluation. Early-onset diabetes and elevated hemoglobin A1c (HbA1c) levels exhibited significant correlations with the early development of PD (ρ = 0.66, P < .001, and ρ = -0.24, P < .001, respectively). Furthermore, having DM at an early age was associated with the occurrence of penile plaque (ρ = -0.18, P = .03), and there were no significant differences in plaque dimensions (ρ = -0.29, P = .053). A rise in HbA1c levels after the initial PD diagnosis displayed positive correlations with the formation of penile plaque (ρ = 0.22, P < .006). CLINICAL IMPLICATIONS: These findings emphasize the need for comprehensive assessments and personalized treatment strategies for individuals with DM and PD. Enhanced management approaches can improve outcomes for those facing both challenges. STRENGTHS AND LIMITATIONS: Limitations include the single-site retrospective design with potential selection bias, inaccuracies in medical record data, and challenges in controlling confounding variables. CONCLUSIONS: This study highlights that early-onset diabetes and poor diabetes control, as indicated by a subsequent rise in HbA1c levels following PD diagnosis, are significantly correlated with the onset and severity of PD. Revealing the mechanisms behind these findings will help us develop better management strategies for individuals with DM and PD.


Asunto(s)
Diabetes Mellitus Tipo 2 , Hemoglobina Glucada , Induración Peniana , Humanos , Induración Peniana/complicaciones , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Diabetes Mellitus Tipo 2/complicaciones , Hemoglobina Glucada/análisis , Hemoglobina Glucada/metabolismo , Anciano , Edad de Inicio , Adulto , Progresión de la Enfermedad , Pene/diagnóstico por imagen , Factores de Riesgo
2.
Pediatr Emerg Care ; 40(8): e120-e125, 2024 Aug 01.
Artículo en Inglés | MEDLINE | ID: mdl-38355140

RESUMEN

OBJECTIVE: We sought to describe patterns of and indications for surgical specialty consultation for facial laceration repair in pediatric emergency departments (PEDs). METHODS: We performed a multicenter survey of PED leadership throughout the United States and Canada evaluating the practice patterns of surgical specialty consultation for patients presenting for facial lacerations requiring repair. We measured demographics of PEDs, factors influencing the decision to obtain a surgical specialty consultation, and the presence and components of consultation guidelines. Factors related to consultation were ranked on a Likert scale from 1 to 5 (1 = Not at all important, 5 = Extremely important). We evaluated relationships between reported rates of surgical specialty consultation and PED region, annual PED volume, and reported factors associated with PED consultation. RESULTS: Survey responses were received from 67/124 (54%) queried PEDs. The median self-reported rate of surgical specialty consultation for facial lacerations was 10% and ranged from 1% to 70%, with resident physicians performing the repair 71% of the time a subspecialist was consulted. There was regional variability in specialty consultation, with the highest and lowest rate in the Midwest and Canada, respectively ( P = 0.03). The top 4 influential factors prompting consultation with the highest percentage of responses of "Extremely Important" or "Very Important" were: discretion of the physician caring for the patient (95%), parental preference (39%), limited PED resources (32%), and patient requires sedation (32%). Surgical specialty consult guidelines were used in only 6% of PEDs with consensus that depth necessitating more than 2-layer repair or involvement of critical structures should prompt consultation. CONCLUSIONS: Surgical specialty usage in the management of patients who present with facial lacerations to PEDs has significant variation related to patient, provider, and department-level factors that influence the decision to consult. Lack of consult guidelines represent a potential opportunity to standardize care delivery to this common presentation.


Asunto(s)
Servicio de Urgencia en Hospital , Traumatismos Faciales , Laceraciones , Pautas de la Práctica en Medicina , Derivación y Consulta , Humanos , Canadá , Laceraciones/cirugía , Estados Unidos , Derivación y Consulta/estadística & datos numéricos , Traumatismos Faciales/cirugía , Encuestas y Cuestionarios , Pautas de la Práctica en Medicina/estadística & datos numéricos , Niño , Especialidades Quirúrgicas , Masculino , Femenino , Pediatría
3.
Pediatr Emerg Care ; 40(4): 307-310, 2024 Apr 01.
Artículo en Inglés | MEDLINE | ID: mdl-37678275

RESUMEN

OBJECTIVE: The aim of the study is to assess diagnostic performance of cardiac point-of-care ultrasound (POCUS) performed by pediatric emergency medicine (PEM) physicians in children with preexisting cardiac disease. METHODS: We evaluated the use of cardiac POCUS performed by PEM physicians among a convenience sample of children with preexisting cardiac disease presenting to a tertiary care pediatric ED. We assessed patient characteristics and the indication for POCUS. The test characteristics of the sonologist interpretation for the assessment of both pericardial effusion as well as left ventricular systolic dysfunction were compared with expert POCUS review by PEM physicians with POCUS fellowship training. RESULTS: A total of 104 children with preexisting cardiac disease underwent cardiac POCUS examinations between July 2015 and December 2017. Among children with preexisting cardiac disease, structural defects were present in 72%, acquired conditions in 22%, and arrhythmias in 13% of patients. Cardiac POCUS was most frequently obtained because of chest pain (55%), dyspnea (18%), tachycardia (17%), and syncope (10%). Cardiac POCUS interpretation compared with expert review had a sensitivity of 100% (95% confidence interval [CI], 85.7-100) for pericardial effusion and 100% (95% CI, 71.5-100) for left ventricular systolic dysfunction; specificity was 97.5% (95% CI, 91.3.1-99.7) for pericardial effusion and 98.9% (95% CI, 93.8-99.8) for left ventricular systolic dysfunction. CONCLUSIONS: Cardiac POCUS demonstrates good sensitivity and specificity in diagnosing pericardial effusion and left ventricular systolic dysfunction in children with preexisting cardiac conditions when technically adequate studies are obtained. These findings support future studies of cardiac POCUS in children with preexisting cardiac conditions presenting to the ED.


Asunto(s)
Derrame Pericárdico , Disfunción Ventricular Izquierda , Humanos , Niño , Derrame Pericárdico/diagnóstico por imagen , Sistemas de Atención de Punto , Ultrasonografía , Corazón , Disfunción Ventricular Izquierda/diagnóstico por imagen , Servicio de Urgencia en Hospital
4.
J Urol ; 209(2): 399-409, 2023 02.
Artículo en Inglés | MEDLINE | ID: mdl-36383789

RESUMEN

PURPOSE: Our aim was to determine if the AUA-recommended prophylaxis (vancomycin + gentamicin alone) for primary inflatable penile prosthesis surgery is associated with a higher infection risk than nonstandard regimens. MATERIALS AND METHODS: We performed a multicenter, retrospective study of patients undergoing primary inflatable penile prosthesis surgery. Patients were divided into those receiving vancomycin + gentamicin alone and those receiving any other regimen. A Cox proportional-hazards model was constructed adjusted for major predictors. A subgroup analysis to identify the appropriate dosage of gentamicin was also performed. RESULTS: A total of 4,161 patients underwent primary inflatable penile prosthesis placement (2,411 received vancomycin + gentamicin alone and 1,750 received other regimens). The infection rate was similar between groups, 1% vs 1.2% for standard vs nonstandard prophylaxis. In the multivariable analysis, vancomycin + gentamicin (HR: 2.7, 95% CI: 1.4 to 5.4, P = .004) and diabetes (HR: 1.9, 95% CI: 1.03 to 3.4, P = .04) were significantly associated with a higher risk of infection. Antifungals (HR: 0.08, 95% CI: 0.03 to 0.19, P < .001) were associated with lower risk of infection. There was no statistically significant difference in infection rate between weight-based gentamicin compared to 80 mg gentamicin (HR: 2.9, 95% CI: 0.83 to 10, P = .1). CONCLUSIONS: Vancomycin + gentamicin alone for antibiotic prophylaxis for primary inflatable penile prosthesis surgery is associated with a higher infection risk than nonstandard antibiotic regimens while antifungal use is associated with lower infection risk. A critical review of the recommended antimicrobial prophylactic regimens is needed. Prospective research is needed to further elucidate best practices in inflatable penile prosthesis antimicrobial prophylaxis.


Asunto(s)
Disfunción Eréctil , Implantación de Pene , Prótesis de Pene , Masculino , Humanos , Profilaxis Antibiótica , Vancomicina/uso terapéutico , Estudios Retrospectivos , Estudios Prospectivos , Complicaciones Posoperatorias/cirugía , Prótesis de Pene/efectos adversos , Gentamicinas/uso terapéutico , Disfunción Eréctil/cirugía , Estudios Multicéntricos como Asunto
5.
Can J Urol ; 30(2): 11516-11519, 2023 04.
Artículo en Inglés | MEDLINE | ID: mdl-37074753

RESUMEN

The artificial urinary sphincter (AUS) is the "gold standard" surgical treatment for severe stress urinary incontinence.  However, a subset of patients with frail urethras may require technical adjuncts to ensure optimal cuff function.  Our objective is to provide a detailed tutorial of our institution's method for performing urethral bulking with native tissue in patients with frail urethras during AUS surgery. We have found that urethral bulking with native tissue provides a cost-efficient and durable technique for improved AUS cuff coaptation.  Our experience demonstrates adequate short and intermediate term efficacy with limited complications.  These techniques equip surgeons with an alternative surgical approach for appropriate patients receiving AUS surgery who have been previously exposed to pelvic radiation and/or significant surgical morbidity resulting in frail urethral tissue.


Asunto(s)
Incontinencia Urinaria de Esfuerzo , Esfínter Urinario Artificial , Humanos , Esfínter Urinario Artificial/efectos adversos , Uretra/cirugía , Incontinencia Urinaria de Esfuerzo/cirugía , Incontinencia Urinaria de Esfuerzo/etiología , Estudios Retrospectivos
6.
Radiographics ; 42(6): 1654-1669, 2022 10.
Artículo en Inglés | MEDLINE | ID: mdl-36190860

RESUMEN

Substantial advances in percutaneous image-guided minimally invasive musculoskeletal oncologic interventions offer a robust armamentarium for interventional radiologists for management of cancer. The authors outline the most recent advances in such interventions and the role of interventional radiologists in managing cancer in modern-era practice. Percutaneous minimally invasive musculoskeletal interventions including thermal ablation, cementation with or without osseous reinforcement by implants, osteosynthesis, neurolysis, and embolization, as well as palliative injections, have been successfully used by interventional radiologists to achieve durable, timely, safe, effective palliation in a multidisciplinary setting and have been progressively incorporated into the management paradigm for patients with cancer with musculoskeletal involvement. Familiarity with the described interventions and implementation of procedural safety measures, combined with integration of these procedures into clinical practice with the support of the National Comprehensive Cancer Network and the American College of Radiology, as well as continued technologic advances in procedural equipment design, will further enhance the role of interventional radiologists in cancer management. ©RSNA, 2022.


Asunto(s)
Técnicas de Ablación , Embolización Terapéutica , Neoplasias , Técnicas de Ablación/métodos , Humanos , Neoplasias/diagnóstico por imagen , Neoplasias/terapia , Cuidados Paliativos , Radiología Intervencionista
7.
Can J Urol ; 29(3): 11182-11186, 2022 06.
Artículo en Inglés | MEDLINE | ID: mdl-35691041

RESUMEN

Proximal positioning of the penile prosthesis cylinder is performed during inflatable penile prosthesis surgery. We describe a technique to secure a prosthetic cylinder during inflatable penile prosthesis implantation. Urologists performing prosthetic surgeries employ a variety of surgical techniques to achieve successful outcomes. A surgical technique that secures the prosthetic device may ultimately mitigate cylinder migration and erosion. This is a simple, cost-effective technique that can be readily incorporated into conventional corporotomy closure procedures. It proves to be a feasible technique for both running and interrupted corporotomy closures. The "pulley stitch" offers an adjunctive technique for prosthesis cylinder positioning and may also help prevent migration of prosthetic devices, and it can be incorporated with corporotomy closure.


Asunto(s)
Disfunción Eréctil , Implantación de Pene , Prótesis de Pene , Disfunción Eréctil/cirugía , Humanos , Masculino , Implantación de Pene/métodos , Pene/cirugía , Implantación de Prótesis
8.
Pediatr Emerg Care ; 38(2): e805-e810, 2022 Feb 01.
Artículo en Inglés | MEDLINE | ID: mdl-35100780

RESUMEN

OBJECTIVES: Risk tolerance and risk perceptions may impact clinicians' decisions to obtain diagnostic tests. We sought to determine whether physician risk perception was associated with the decision to obtain blood or imaging tests among children who present to the emergency department with fever. METHODS: We conducted a retrospective, cross-sectional study in the Boston Children's Hospital emergency department. We included children aged 6 months to 18 years from May 1, 2014 to April 30, 2019, with fever. Our primary outcome was diagnostic testing: obtaining a blood and/or imaging test. We assessed risk perception using 3 scales: the Risk Tolerance Scale (RTS), Stress From Uncertainty Scale (SUS), and Malpractice Fear Scale (MFS). A z score was assigned to each physician for each scale. Mixed-effects logistic regression assessed the association between physician risk perception and blood or imaging testing. We also examined the relationship between each risk perception scale and several secondary outcomes: blood testing, urine testing, diagnostic imaging, specialist consultation, hospitalization, and revisit within 72 hours. RESULTS: The response rate was 55/56 (98%). We analyzed 12,527 encounters. Blood/imaging testing varied between physicians (median, 48%; interquartile range, 41%-53%; range, 30%-71%). Risk Tolerance Scale responses were not associated with blood/imaging testing (odds ratio [OR], 1.03 per SD of increased risk perception; 95% confidence interval [CI], 0.95-1.13). Stress From Uncertainty Scale responses were not associated with blood/imaging testing (OR, 1.04 per SD; 95% CI, 0.95-1.14). Malpractice Fear Scale responses were not associated with blood/imaging testing (OR, 1.00 per SD; 95% CI, 0.91-1.09). There was no significant association between RTS, MFS, or SUS and any secondary outcome, except that there was a weak association between SUS and specialist consultation (OR, 1.12; 95% CI, 1.00-1.24). CONCLUSIONS: Across 55 pediatric emergency physicians with variable testing practices, there was no association between risk perception and blood/imaging testing in febrile children.


Asunto(s)
Médicos , Niño , Estudios Transversales , Servicio de Urgencia en Hospital , Humanos , Percepción , Estudios Retrospectivos
9.
Pediatr Emerg Care ; 38(1): e300-e305, 2022 Jan 01.
Artículo en Inglés | MEDLINE | ID: mdl-33122503

RESUMEN

OBJECTIVES: We sought to describe the test characteristics of cardiac point-of-care ultrasound (POCUS) performed by pediatric emergency medicine (PEM) physicians after structured cardiac POCUS training. METHODS: We evaluated the use of clinically indicated cardiac POCUS by PEM physicians in a single tertiary care pediatric emergency department after implementation of a focused cardiac POCUS training curriculum. The test characteristics of the sonologist interpretation were compared with expert POCUS review, by PEM physicians who have completed PEM POCUS fellowship training, for the assessment of both pericardial effusion and left ventricular systolic dysfunction. RESULTS: A total of 1241 cardiac POCUS examinations were performed between July 2015 and December 2017, of which 456 were clinically indicated and underwent expert POCUS review and comprised the study sample. These examinations were performed by 33 different PEM attending sonologists. Chest pain (52%), dyspnea (20%), and tachycardia (18%) were the most common indications for cardiac POCUS. Prevalence of pericardial effusion and global systolic dysfunction based on expert POCUS review were 11% (48/443) and 4% (16/435), respectively. Real-time cardiac POCUS interpretation had a sensitivity and specificity of 100% and 99.5%, respectively, for both pericardial effusion and left ventricular systolic dysfunction when compared with expert POCUS review. CONCLUSIONS: Cardiac POCUS is both sensitive and specific for identifying pericardial effusion and left ventricular systolic dysfunction when performed by PEM attendings with focused training.


Asunto(s)
Medicina de Emergencia , Medicina de Urgencia Pediátrica , Niño , Servicio de Urgencia en Hospital , Humanos , Sistemas de Atención de Punto , Ultrasonografía
10.
Pediatr Emerg Care ; 37(12): e1265-e1269, 2021 Dec 01.
Artículo en Inglés | MEDLINE | ID: mdl-31913246

RESUMEN

OBJECTIVE: Traditionally, patient-reported fasting time has been the primary objective presedation measure of aspiration risk. Recently, gastric ultrasound has been used to assess gastric volume for the determination of aspiration risk in patients undergoing anesthesia in the operative setting. We sought to determine the correlation of gastric volume estimated by point-of-care ultrasound (POCUS) to reported fasting time. METHODS: We included children 4 to 18 years of age who presented with an acute traumatic injury. Enrolled children underwent POCUS to calculate gastric volume, which was calculated using a validated formula: Volume (mL) = -7.8 + (3.5 × Cross-sectional Area [CSA]) + (0.127 × Age in months). The CSA was measured (CSA = (anterior-posterior diameter × craniocaudal diameter × π)/4). We analyzed the relationship between time since last reported oral intake and measured gastric volume using Spearman rank correlation (ρ). RESULTS: A total of 103 patients with a median age of 10.5 years (interquartile range, 7.3-13.7 years) were enrolled. The gastric antrum was identified and measured in 88 (85%) patients; air obstructing the posterior surface of the gastric antrum prevented measurement in 14 of the 15 remaining patients. We observed a weak inverse correlation between fasting time (either liquid or solid) and estimated gastric volume (ρ = -0.33), with no significant difference based on type of intake (solids, ρ = 0.28; liquids, ρ = 0.22). CONCLUSION: Gastric volume can be estimated by POCUS and is not strongly correlated with fasting time in children in the emergency department setting.


Asunto(s)
Ayuno , Sistemas de Atención de Punto , Adolescente , Niño , Contenido Digestivo/diagnóstico por imagen , Humanos , Estudios Prospectivos , Ultrasonografía
11.
J Vasc Interv Radiol ; 31(11): 1745-1752, 2020 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-33129427

RESUMEN

PURPOSE: To evaluate the effectiveness of radiofrequency (RF) ablation as measured by change in worst pain score from baseline to 3 mo after RF ablation for the palliative treatment of painful bone metastases. MATERIALS AND METHODS: One hundred patients (mean age, 64.6 y) underwent RF ablation for metastatic bone disease and were followed up to 6 mo. Subjects' pain and quality of life were measured before RF ablation and postoperatively by using the Brief Pain Index and European Quality of Life questionnaires. Opioid agent use and device-, procedure-, and/or therapy-related adverse events (AEs) were collected. RESULTS: Eighty-seven patients were treated for tumors involving the thoracolumbar spine and 13 for tumors located in the pelvis and/or sacrum. All ablations were technically successful, and 97% were followed by cementoplasty. Mean worst pain score decreased from 8.2 ± 1.7 at baseline to 3.5 ± 3.2 at 6 mo (n = 22; P < 0.0001 for all visits). Subjects experienced significant improvement for all visits in average pain (P < .0001), pain interference (P < .0001), and quality of life (P < .003). Four AEs were reported, of which 2 resulted in hospitalization for pneumonia and respiratory failure. All 30 deaths reported during the study were attributed to the underlying malignancy and not related to the study procedure. CONCLUSIONS: Results from this study show rapid (within 3 d) and statistically significant pain improvement with sustained long-term relief through 6 mo in patients treated with RF ablation for metastatic bone disease.


Asunto(s)
Neoplasias Óseas/cirugía , Dolor/prevención & control , Cuidados Paliativos , Ablación por Radiofrecuencia , Adulto , Anciano , Anciano de 80 o más Años , Neoplasias Óseas/complicaciones , Neoplasias Óseas/mortalidad , Neoplasias Óseas/secundario , Cementoplastia , Femenino , Humanos , Masculino , Persona de Mediana Edad , Dolor/diagnóstico , Dolor/etiología , Dolor/mortalidad , Dimensión del Dolor , Estudios Prospectivos , Calidad de Vida , Ablación por Radiofrecuencia/efectos adversos , Ablación por Radiofrecuencia/mortalidad , Factores de Tiempo , Resultado del Tratamiento
12.
Am J Emerg Med ; 38(1): 1-6, 2020 01.
Artículo en Inglés | MEDLINE | ID: mdl-30795947

RESUMEN

OBJECTIVE: We sought to assess interrater reliability (IRR) of lung point-of-care ultrasound (POCUS) findings among pediatric patients with suspected pneumonia. METHODS: A convenience sample of patients between the ages of 6 months and 18 years with a clinical suspicion of pneumonia had a lung ultrasound performed by a POCUS-credentialed emergency medicine physician with subsequent expert review. Each lung zone was assessed as either normal or abnormal, and specific ultrasound findings were recorded. IRR was assessed by intraclass correlation coefficient (ICC) and kappa statistics. RESULTS: Seventy-one patients, with a total of 852 lung zones imaged, were included. The sonographer assessment of normal versus abnormal, across each of the zones, demonstrated moderate agreement with ICC 0.46 (95% CI: 0.41, 0.52) and kappa 0.56. Right-sided zones demonstrated moderate agreement [0.43 (CI 0.35, 0.51)] while left-sided zones, specifically left-sided anterior zones, showed only fair agreement [0.36 (0.28, 0.44)]. IRR varied between specific findings: ICC for B-lines 0.52 (95% CI: 0.46, 0.57), pleural effusion 0.40 (0.34, 0.45), consolidation 0.39 (0.33, 0.44), subpleural consolidation 0.31 (0.25, 0.37), and pleural line irregularity 0.16 (0.10, 0.23). A composite indicator of typical pneumonia findings (consolidation, B-lines, and pleural effusion) demonstrated moderate [ICC 0.52 (0.46, 0.57)] reliability. CONCLUSIONS: We found moderate interrater reliability of lung POCUS findings for the assessment of pediatric patients with suspected pneumonia. B-lines had the highest reliability. Further assessment of lung POCUS is necessary to guide proper training and optimal scanning techniques to ensure adequate reliability of ultrasound findings in the assessment of pediatric pneumonia.


Asunto(s)
Servicio de Urgencia en Hospital , Pulmón/diagnóstico por imagen , Neumonía/diagnóstico por imagen , Sistemas de Atención de Punto , Adolescente , Niño , Preescolar , Femenino , Humanos , Lactante , Masculino , Reproducibilidad de los Resultados , Ultrasonografía/métodos
13.
Nature ; 494(7438): 480-3, 2013 Feb 28.
Artículo en Inglés | MEDLINE | ID: mdl-23446419

RESUMEN

Biologists have long been concerned about what constrains variation in cell size, but progress in this field has been slow and stymied by experimental limitations. Here we describe a new method, ergodic rate analysis (ERA), that uses single-cell measurements of fixed steady-state populations to accurately infer the rates of molecular events, including rates of cell growth. ERA exploits the fact that the number of cells in a particular state is related to the average transit time through that state. With this method, it is possible to calculate full time trajectories of any feature that can be labelled in fixed cells, for example levels of phosphoproteins or total cellular mass. Using ERA we find evidence for a size-discriminatory process at the G1/S transition that acts to decrease cell-to-cell size variation.


Asunto(s)
Ciclo Celular/fisiología , Tamaño de la Célula , Retroalimentación Fisiológica , Análisis de la Célula Individual/métodos , Recuento de Células , Ciclo Celular/efectos de los fármacos , Línea Celular , Proliferación Celular , Tamaño de la Célula/efectos de los fármacos , Cicloheximida , Dimetilsulfóxido , Fase G1/efectos de los fármacos , Fase G1/fisiología , Células HeLa , Humanos , Leupeptinas , Fosfoproteínas , Fase S/fisiología , Sirolimus
15.
J Emerg Med ; 54(1): 96-101, 2018 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-29110982

RESUMEN

BACKGROUND: Point-of-care ultrasound (POCUS) is increasingly being used to differentiate cellulitis from abscess in the pediatric emergency department (ED). POCUS has also been shown to decrease length of stay (LOS) for other applications among adult patients. OBJECTIVE: We sought to determine if ED LOS differed for children presenting with skin and soft tissue infections who received POCUS versus radiology-performed ultrasound. METHODS: We performed a retrospective cohort study of children presenting to an urban pediatric ED between January 2011 and June 2013 with a diagnosis of cellulitis or abscess who underwent soft tissue ultrasound. Patients who received a surgical consult, had significant medical comorbidities, or had a lesion located on the face, hands, feet, or groin were excluded. We compared ED LOS among children who received radiology-performed ultrasound to children who received POCUS, adjusting for relevant clinical variables. RESULTS: Among 3094 children with a diagnosis of cellulitis or abscess, we identified 202 who underwent a POCUS and 118 who underwent radiology-performed ultrasound. The POCUS group had a shorter median LOS than the radiology-performed ultrasound group (adjusted median difference -73 min; 95% confidence interval -93.6 to -52.4 min). In the subset of patients discharged from the ED, this difference was more pronounced (adjusted median difference -89 min; 95% confidence interval -109.9 to -68.1 min). CONCLUSION: Among children presenting to a pediatric ED with superficial skin and soft tissue infections, children receiving POCUS experienced shorter LOS compared to children receiving radiology-performed ultrasound.


Asunto(s)
Tiempo de Internación/estadística & datos numéricos , Pediatría/métodos , Infecciones de los Tejidos Blandos/diagnóstico , Ultrasonografía/métodos , Adolescente , Niño , Preescolar , Medicina de Emergencia/métodos , Medicina de Emergencia/normas , Servicio de Urgencia en Hospital/organización & administración , Servicio de Urgencia en Hospital/tendencias , Femenino , Humanos , Lactante , Masculino , Pediatría/normas , Sistemas de Atención de Punto/normas , Sistemas de Atención de Punto/tendencias , Ultrasonografía/normas
16.
Can J Urol ; 24(4): 8934-8936, 2017 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-28832315

RESUMEN

Gross hematuria is a common occurrence in adults. The differential diagnosis is extensive, including: malignancy, trauma, inflammation of the urinary tract, and stones. While, urinary tract amyloidosis represents only a small percentage of causative gross hematuria, it is concerning because of its superficial resemblance to malignant processes. We report the case of an 82-year-old male with concurrent primary amyloidosis of the kidney, ureter and bladder in the setting of acute hemorrhage. Histopathological examination of several biopsied samples confirmed our diagnosis. A nephroureterectomy with bladder cuff was successfully performed without complication along with watchful waiting for the bladder amyloidosis.


Asunto(s)
Amiloidosis/complicaciones , Hemorragia/etiología , Enfermedades Renales/complicaciones , Enfermedades Ureterales/complicaciones , Enfermedades de la Vejiga Urinaria/complicaciones , Enfermedad Aguda , Anciano de 80 o más Años , Humanos , Masculino
17.
Emerg Med J ; 34(1): 8-12, 2017 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-27694335

RESUMEN

OBJECTIVES: The presence of critically ill patients may impact care for other ED patients. We sought to evaluate whether the presence of a critically ill child was associated with the time to (1) receipt of the first medication among other patients, and (2) administration of diagnosis-specific medications. METHODS: We performed a retrospective cohort study of all paediatric ED visits over 3 years. Patients were exposed if they arrived during the first hour of a critically ill patient's care. The primary outcome was the time from arrival to first medication administration. Secondary outcomes were time to corticosteroids in asthma and time to antibiotics for fever/neutropenia. We modelled times to medication using median regression, adjusting for demographics, arrival time and weekday, and census (number of patients in the ED). RESULTS: We analysed 170 112 visits. Median times to first medication for those exposed to 0, 1 and >1 simultaneous critically ill patients were 90 min (IQR 54-146), 96 min (IQR 58-157) and 113 min (IQR 72-166), respectively (p<0.001). The increase in time to corticosteroids among exposed patients versus unexposed was 6 min (IQR 2-14, p=0.11) and in time to antibiotic for fever/neutropenia was -4 min (IQR -4 to -11, p=0.13). Modelled time to first medication increased 3.1 min (95% CI 0.5 to 5.7) among all exposed patients (p=0.02). Time to first medication increased 15.3 min (95% CI 14.7 to 15.9) for each 10 patient increase in census. CONCLUSIONS: The presence of critically ill patients was associated with a delay in medication administration to others. Census independently predicted medication delays.


Asunto(s)
Asma/tratamiento farmacológico , Enfermedad Crítica , Servicio de Urgencia en Hospital/organización & administración , Fiebre/tratamiento farmacológico , Gastroenteritis/tratamiento farmacológico , Tiempo de Tratamiento , Niño , Aglomeración , Femenino , Humanos , Masculino , Estudios Retrospectivos , Centros Traumatológicos , Estados Unidos
18.
Pediatr Emerg Care ; 33(10): 700-702, 2017 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-28968307

RESUMEN

We report a case of a patient presenting with abdominal pain after cardiac surgery who was noted on point-of-care ultrasound (POCUS) to have pericardial and pleural effusion, in addition to ascites. The most notable findings were pleural and pericardial effusions, which combined with symptomatology met criteria for postpericardiotomy syndrome. Point-of-care ultrasound expedited the diagnosis of a pericardial effusion with impending tamponade and transfer for pericardiocentesis and placement of pericardial drain.


Asunto(s)
Sistemas de Atención de Punto , Síndrome Pospericardiotomía/diagnóstico por imagen , Ultrasonografía/métodos , Niño , Humanos , Masculino , Derrame Pericárdico/diagnóstico por imagen , Derrame Pericárdico/etiología , Pericardiocentesis/métodos , Derrame Pleural/diagnóstico por imagen , Derrame Pleural/etiología , Síndrome Pospericardiotomía/cirugía
19.
J Pediatr ; 169: 122-7.e1, 2016 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-26563535

RESUMEN

OBJECTIVES: To determine the test characteristics of point-of-care ultrasonography for the identification of a drainable abscess and to compare the test characteristics of ultrasonography with physical examination. In addition, we sought to measure the extent to which ultrasonography impacts clinical management of children with skin and soft tissue infections (SSTIs). STUDY DESIGN: We performed a prospective study of children with SSTIs evaluated in a pediatric emergency department. Treating physicians recorded their initial impression of whether a drainable abscess was present based on physical examination. Another physician, blinded to the treating physician's assessment, performed an ultrasound study and conveyed their interpretation and recommendations to the treating physician. Any management change was recorded. An abscess was defined as a lesion from which purulent fluid was expressed during a drainage procedure in the emergency department or during the 2- to 5-day follow-up period. We defined a change in management as correct when the ultrasound diagnosis was discordant from physical examination and matched the ultimate lesion classification. RESULTS: Of 151 SSTIs evaluated among 148 patients, the sensitivity and specificity of point-of-care ultrasonography for the presence of abscess were 96% (95% CI 90%-99%) and 87% (74%-95%), respectively. The sensitivity and specificity of physical examination for the presence of abscess were 84% (75%-90%) and 60% (44%-73%), respectively. For every 4 ultrasound examinations performed, there was 1 correct change in management. CONCLUSIONS: Point-of-care ultrasonography demonstrates excellent test characteristics for the identification of skin abscess and has superior test characteristics compared with physical examination alone.


Asunto(s)
Absceso/diagnóstico por imagen , Sistemas de Atención de Punto , Infecciones de los Tejidos Blandos/diagnóstico por imagen , Adolescente , Niño , Preescolar , Femenino , Humanos , Masculino , Examen Físico , Estudios Prospectivos , Sensibilidad y Especificidad , Infecciones de los Tejidos Blandos/diagnóstico , Ultrasonografía
20.
Pediatr Emerg Care ; 32(5): 315-7, 2016 May.
Artículo en Inglés | MEDLINE | ID: mdl-27139293

RESUMEN

We present the clinical and radiological findings involving a mesenteric lymphatic malformation causing volvulus in a toddler presenting with acute abdominal pain, as well as its treatment options.


Asunto(s)
Abdomen Agudo/diagnóstico , Vólvulo Intestinal/diagnóstico , Sistema Linfático/anomalías , Mesenterio/anomalías , Abdomen Agudo/cirugía , Preescolar , Diagnóstico Diferencial , Diagnóstico por Imagen , Humanos , Vólvulo Intestinal/cirugía , Sistema Linfático/cirugía , Masculino , Mesenterio/cirugía
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA