RESUMEN
The laboratory mouse shares the majority of its protein-coding genes with humans, making it the premier model organism in biomedical research, yet the two mammals differ in significant ways. To gain greater insights into both shared and species-specific transcriptional and cellular regulatory programs in the mouse, the Mouse ENCODE Consortium has mapped transcription, DNase I hypersensitivity, transcription factor binding, chromatin modifications and replication domains throughout the mouse genome in diverse cell and tissue types. By comparing with the human genome, we not only confirm substantial conservation in the newly annotated potential functional sequences, but also find a large degree of divergence of sequences involved in transcriptional regulation, chromatin state and higher order chromatin organization. Our results illuminate the wide range of evolutionary forces acting on genes and their regulatory regions, and provide a general resource for research into mammalian biology and mechanisms of human diseases.
Asunto(s)
Genoma/genética , Genómica , Ratones/genética , Anotación de Secuencia Molecular , Animales , Linaje de la Célula/genética , Cromatina/genética , Cromatina/metabolismo , Secuencia Conservada/genética , Replicación del ADN/genética , Desoxirribonucleasa I/metabolismo , Regulación de la Expresión Génica/genética , Redes Reguladoras de Genes/genética , Estudio de Asociación del Genoma Completo , Humanos , ARN/genética , Secuencias Reguladoras de Ácidos Nucleicos/genética , Especificidad de la Especie , Factores de Transcripción/metabolismo , Transcriptoma/genéticaRESUMEN
The nitrogenization of phenyl rings on DIM derivatives not only enhances molecular coplanarity but also stabilizes molecular LUMO levels, favoring charge transfer and improving air stability. Therefore, n-type organic field-effect transistors (OFETs) that are based on DIM-N2C8 with nitrogen atoms on both sides of the phenyl rings exhibit a moderate electron mobility of 0.059 cm2 V-1 s-1 under ambient conditions.
RESUMEN
The synthesis, characterization, and application of two angular-shaped naphthalene bis(1,5-diamide-2,6-diylidene)malononitriles (NBAMs) as high-performance air-stable n-type organic field effect transistor (OFET) materials are reported. NBAM derivatives exhibit deep lowest-unoccupied molecular orbital (LUMO) levels, suitable for air-stable n-type OFETs. The OFET device based on NBAM-EH fabricated by vapor deposition exhibits a maximum electron mobility of 0.63 cm2 V-1 s-1 in air with an on/off current ratio ( Ion/ Ioff) of 105.