Is Asian flushing syndrome a disadvantage in the labor market?

A large fraction of people in East Asia are incapable of digesting alcohol because of a genetic deficiency. This study examines whether the variation in alcohol tolerance contributes to inequality in the labor market. We conduct our original surveys in Japan, Taiwan, and Korea with the measurement of respondents' degree of alcohol tolerance by a bio-marker test. We find that alcohol-tolerant men consume significantly more alcohol, but their earnings and hours worked do not differ from those of alcohol-intolerant men. Despite a prevalent view that drinking alcohol is indispensable to establish good relationships with colleagues and business partners, our results suggest that there is no systematic impact of alcohol tolerance on labor market outcomes.

Long-term impacts of early-life exposure to malaria: Evidence from Taiwan's Eradication Campaign in the 1950s.

This paper utilizes the eradication campaign in Taiwan in the 1950s to estimate the long-term impacts of early-life (in utero and postnatal) exposure to malaria. Matching adults in the 1992-2012 Taiwan Social Change Survey to the malaria intensity in their individual place and year of birth, difference-in-difference estimation shows strong evidence that the eradication increased men's own educational attainment as well as their family income in adulthood. We also use the 1980 census data to show there was a sharp education increase after the eradication. Furthermore, the eradication increased the educational attainment of married men's spouses. Finally, quantile regressions show that the effect concentrated on the lower percentile of the income distribution. Overall, our results suggest negative effects of early-life exposure to malaria.

HBeAg(+) and sex ratio of offspring: evidence form Taiwan's three million newborns.

OBJECTIVE: Mothers sero-positive for hepatitis B are slightly more likely to have a son. It is not known whether it is ever having HBV (HBsAg[+]) or currently active HBV (HBeAg[+]) which is associated with having a son. METHOD: Multivariable linear regression was used to assess the adjusted association of HBeAg(+) with offspring sex in all (90%) births (~3 million) in Taiwan from 1988 to 1999. RESULTS: Totally, 5% of mothers were HBeAg(+). HBeAg(+) mothers were slightly more likely to have a son (sex ratio 108 rather than 106) adjusted for HBsAg, birth order, mother's age, birth year, and area of residence. CONCLUSION: At a population level HBV status makes little difference to the sex ratio at birth.

Political ideology predicts preventative behaviors and infections amid COVID-19 in democracies.

Can one's political ideology predict his or her testing positive for COVID-19 and how? The present study leveraged a recent (April-May 2020) survey of 27,260 individuals across 27 democracies to investigate the associations between political ideology and coronavirus infections. Our individual-level data and mediation analyses allow us to tease out different correlational paths according to which one's political ideology affects his or her infection. We found a more right-leaning attitude to be associated with a higher probability of testing positive both directly and indirectly through conspiracy theory beliefs and physical distancing. Moreover, our cross-national investigation also found that becoming more right-leaning in ideology was associated with a higher level of perceived risk of COVID-19 infection, which made one less likely to test positive. Combined, we provide a more nuanced understanding of the role played by political ideology in the current pandemic, on which the design of a more effective risk communication strategy can be based.

Skin wound healing assessment via an optimized wound array model in miniature pigs.

An appropriate animal wound model is urgently needed to assess wound dressings, cell therapies, and pharmaceutical agents. Minipig was selected owing to similarities with humans in body size, weight, and physiological status. Different wound sizes (0.07-100 cm2) were created at varying distances but fail to adequately distinguish the efficacy of various interventions. We aimed to resolve potential drawbacks by developing a systematic wound healing system. No significant variations in dorsal wound closure and contraction were observed within the thoracolumbar region between boundaries of both armpits and the paravertebral region above rib tips; therefore, Lanyu pigs appear suitable for constructing a reliable dorsal wound array. Blood flow signals interfered with inter-wound distances ˂ 4 cm; a distance > 4 cm is therefore recommended. Wound sizes ≥ 4 cm × 4 cm allowed optimal differentiation of interventions. Partial- (0.23 cm) and full-thickness (0.6 cm) wounds showed complete re-epithelialization on days 13 and 18 and strongest blood flow signals at days 4 and 11, respectively. Given histological and tensile strength assessments, tissue healing resembling normal skin was observed at least after 6 months. We established some golden standards for minimum wound size and distance between adjacent wounds for effectively differentiating interventions in considering 3R principles.

National identity predicts public health support during a global pandemic.

Changing collective behaviour and supporting non-pharmaceutical interventions is an important component in mitigating virus transmission during a pandemic. In a large international collaboration (Study 1, N = 49,968 across 67 countries), we investigated self-reported factors associated with public health behaviours (e.g., spatial distancing and stricter hygiene) and endorsed public policy interventions (e.g., closing bars and restaurants) during the early stage of the COVID-19 pandemic (April-May 2020). Respondents who reported identifying more strongly with their nation consistently reported greater engagement in public health behaviours and support for public health policies. Results were similar for representative and non-representative national samples. Study 2 (N = 42 countries) conceptually replicated the central finding using aggregate indices of national identity (obtained using the World Values Survey) and a measure of actual behaviour change during the pandemic (obtained from Google mobility reports). Higher levels of national identification prior to the pandemic predicted lower mobility during the early stage of the pandemic (r = -0.40). We discuss the potential implications of links between national identity, leadership, and public health for managing COVID-19 and future pandemics.

Using Facebook data to predict the 2016 U.S. presidential election.

We use 19 billion likes on the posts of top 2000 U.S. fan pages on Facebook from 2015 to 2016 to measure the dynamic ideological positions for politicians, news outlets, and users at the national and state levels. We then use these measures to derive support rates for 2016 presidential candidates in all 50 states, to predict the election, and to compare them with state-level polls and actual vote shares. We find that: (1) Assuming that users vote for candidates closer to their own ideological positions, support rates calculated using Facebook predict that Trump will win the electoral college vote while Clinton will win the popular vote. (2) State-level Facebook support rates track state-level polling averages and pass the cointegration test, showing two time series share similar trends. (3) Compared with actual vote shares, polls generally have smaller margin of errors, but polls also often overestimate Clinton's support in right-leaning states. Overall, we provide a method to forecast elections at low cost, in real time, and based on passively revealed preference and little researcher discretion.

Do lower birth weight babies have lower grades? Twin fixed effect and instrumental variable method evidence from Taiwan.

By combining two unique Taiwanese datasets, this paper investigates how birth weight affects grades at age 15 years. To tackle the endogeneity problem caused by omitted variables, we first compare birth weight and grade variation within twins. We find that birth weight does increase grades but only when both twins weigh less than 3000g at birth, which indicates that the effect is non-linear, and when the weight difference between the twins is larger than 200g. Furthermore, twin fixed effect estimates are similar to the ordinary least squares (OLSs) ones. We then use the public health budget and the number of doctors in the county where the children were born as instrumental variables for the children's birth weight. We found that instrumental variable estimates are significant only for the less educated (<9 years) and young (<25 years) mothers. We conclude that the effect of birth weight is real and non-linear and its effect on less educated and young mothers is the most severe. Furthermore, the bias produced by OLS may not be large if the correct subgroup of the population has been identified.

Toward reliable retrieval of functional information of papillary dermis using spatially resolved diffuse reflectance spectroscopy.

Spatially resolved diffuse reflectance spectroscopy (SRDRS) has been employed to quantify tissue optical properties and its interrogation volume is majorly controlled by the source-to-detector separations (SDSs). To noninvasively quantify properties of dermis, a SRDRS setup that includes SDS shorter than 1 mm is required. It will be demonstrated in this study that Monte Carlo simulations employing the Henyey-Greenstein phase function cannot always precisely predict experimentally measured diffuse reflectance at such short SDSs, and we speculated this could be caused by the non-negligible backward light scattering at short SDSs that cannot be properly modeled by the Henyey-Greenstein phase function. To accurately recover the optical properties and functional information of dermis using SRDRS, we proposed the use of the modified two-layer (MTL) geometry. Monte Carlo simulations and phantom experiment results revealed that the MTL probing geometry was capable of faithfully recovering the optical properties of upper dermis. The capability of the MTL geometry in probing the upper dermis properties was further verified through a swine study, and it was found that the measurement results were reasonably linked to histological findings. Finally, the MTL probe was utilized to study psoriatic lesions. Our results showed that the MTL probe was sensitive to the physiological condition of tissue volumes within the papillary dermis and could be used in studying the physiology of psoriasis.

Does in utero exposure to Illness matter? The 1918 influenza epidemic in Taiwan as a natural experiment.

This paper tests whether in utero conditions affect long-run developmental outcomes using the 1918 influenza pandemic in Taiwan as a natural experiment. Combining several historical and current datasets, we find that cohorts in utero during the pandemic are shorter as children/adolescents and less educated compared to other birth cohorts. We also find that they are more likely to have serious health problems including kidney disease, circulatory and respiratory problems, and diabetes in old age. Despite possible positive selection on health outcomes due to high infant mortality rates during this period (18%), our paper finds a strong negative impact of in utero exposure to influenza.

As low birth weight babies grow, can well-educated parents buffer this adverse factor? A research note.

This research note combines two national Taiwanese data sets to investigate the relationships among low birth weight (LBW) babies, their parents' educational levels, and their future academic outcomes. We find that LBW is negatively correlated with the probability of such children attending college at age 18; however, when both parents are college or high school graduates, such negative effects may be partially offset. We also show that discrimination against daughters occurs, but only for daughters who were LBW babies. Moreover high parental education can buffer the LBW shock only among moderately LBW children (as compared with very LBW children) and full-term LBW children (as compared with preterm LBW children).