Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 92
Filtrar
Más filtros

Banco de datos
País/Región como asunto
Tipo del documento
Intervalo de año de publicación
1.
BMC Pediatr ; 22(1): 339, 2022 06 11.
Artículo en Inglés | MEDLINE | ID: mdl-35690742

RESUMEN

BACKGROUND: Obesity is considered to be one of the most important factors reducing the sense of happiness and satisfaction with life, especially among women. This belief already exists in middle childhood, as the preschool period is a crucial point in the development of attitudes towards beauty. Preschoolers can identify physically attractive individuals, and they might already form attributions regarding the looks of adults (especially women), which in turn may constitute a foundation for their future concept of beauty-related happiness. Children's attitudes towards the body are also strongly influenced by the content of gender stereotypes that prescribe and proscribe what women and men should look like. In our study, we aimed to analyse the relationship between associations of obesity and happiness made by preschool girls and boys (5-year-olds). METHODS: A total of 680 families with five-year-old children (329 girls, 351 boys; Mage = 5.7 years) and both parents took part in the study. Children's associations of different types of body sizes with perceptions of happiness were measured with the Beauty & Health pictorial scale. RESULTS: Our results indicate that obese bodies were seen as unattractive, independent of gender (p < .001). Children associated looks with happiness-the body type identified as the most physically attractive was also seen as a happiest person. Lowest happiness scores were also ascribed to obese body types, but girls assessed men with a normal body type as happier than boys (t = 2.87, p = .004). CONCLUSIONS: Female bodies are already perceived along gender stereotypical lines at the age of 5, and are also related to potential predictions concerning women's happiness. Children assessed female individuals with slim bodies, as well as those with normal weight, as happier than obese females.


Asunto(s)
Belleza , Felicidad , Adulto , Índice de Masa Corporal , Niño , Preescolar , Escolaridad , Femenino , Humanos , Masculino , Obesidad , Padres
2.
J Relig Health ; 61(5): 4226-4244, 2022 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-35963912

RESUMEN

The coronavirus pandemic (COVID-19), as a widespread health threat, has triggered an increase in health-related behaviours, both pro-and anti-health, especially with regard to diet and physical activity. One of the factors modifying the intensity of such activities may be the religious doctrine and religiosity with which a person is associated. A total of 1502 people (1147 women) from countries that feature one dominant religion, took part in the study. Participants represented Sunni Islam (Egypt, n = 798), Roman Catholicism (Poland, n = 443) and Orthodox Christianity (Romania, n = 261). The Coronavirus Anxiety Scale, the Eating Attitudes Test and the Inventory of Physical Activity Objectives were used in the study. Fear of COVID-19 is associated with engagement in pro-health activity, although not to such a significant extent as might be expected. The type of religion in question was revealed to moderate this relationship, but the intensity of religiosity was not found to serve as a moderator.


Asunto(s)
COVID-19 , Cristianismo , Control de Enfermedades Transmisibles , Egipto/epidemiología , Femenino , Humanos , Pandemias , Polonia , Religión , Rumanía
3.
BMC Pregnancy Childbirth ; 21(1): 114, 2021 Feb 08.
Artículo en Inglés | MEDLINE | ID: mdl-33557768

RESUMEN

BACKGROUND: This retrospective study aimed to identify possible intensification of mental health difficulties among women seeking support in the postpartum period during the epidemic state in Poland. We assumed that the epidemic crisis, social isolation, and restrictions in hospitals which affect pregnant and postpartum women - lack of family labors, lack of the possibility to be with the newborn when he/she is hospitalized, may increase fear and reduce psychosocial resources of women, hinder their normal process of transition to motherhood and thus contribute to the intensified severity of depressive symptoms. METHODS: The study participants were women seeking support at the on-line platform of the project 'Next Stop: Mum', which is a part of the postpartum depression prevention's program implemented by the Ministry of Health in Poland, and enables remote self-screening for the severity of the postpartum depression symptoms with the Edinburgh Postnatal Depression Scale developed by Cox and collaborators. The analyzed data in this study were obtained from 139 women: 61 filled forms from October 1 - November 10, 2019 (non-epidemic period), and 78 filled forms from February 20-March 30 (beginning of the COVID-19 epidemic), 2020. RESULTS: A statistically significant difference in the severity of postpartum depression symptoms were observed among women making a self-assessment with EPDS scale at the beginning of the COVID-19 epidemic in Poland (M = 15.71; SD = 6.23), compared to the pre-epidemic neutral period (M = 13.56; SD = 6.46). CONCLUSIONS: The results of this study indicate that the epidemic crisis may be associated with an increased need for additional caution and support of women's mental health in the postpartum period. We believe that recommendations for medical staff, policy, and families of women struggling with postpartum depression symptoms during crisis should be widespread as the second wave of COVID-19 disease may develop in the autumn-winter 2020 and spring 2021.


Asunto(s)
COVID-19/epidemiología , COVID-19/psicología , Depresión Posparto/epidemiología , Depresión/epidemiología , Salud Materna , Pandemias , Periodo Posparto/psicología , Sistemas de Apoyo Psicosocial , SARS-CoV-2 , Adulto , COVID-19/virología , Depresión/prevención & control , Depresión/psicología , Depresión Posparto/prevención & control , Depresión Posparto/psicología , Femenino , Humanos , Recién Nacido , Salud Mental , Polonia/epidemiología , Embarazo , Escalas de Valoración Psiquiátrica , Estudios Retrospectivos , Autoinforme , Autoevaluación (Psicología)
4.
J Exp Biol ; 223(Pt 15)2020 08 13.
Artículo en Inglés | MEDLINE | ID: mdl-32561625

RESUMEN

One of the key elements of an animal's Darwinian fitness is its ability to adequately respond to and cope with challenging situations. Glucocorticoid hormones, such as corticosterone, affect an organism's ability to overcome such challenges. We hypothesized that changes in the glucocorticoid response curve contribute to the evolution of increased performance during challenging conditions, and tested it on bank voles (Myodes glareolus) from a multidirectional artificial selection experiment, which involves lines selected for high aerobic exercise metabolism achieved during swimming (A - Aerobic), predatory behavior towards a cricket (P - Predatory) and ability to maintain body mass on a low-quality herbivorous diet (H - Herbivorous), as well as unselected control lines (C - Control). We elicited a glucocorticoid response either by restraining the animal or by maximum pharmacological stimulation, and measured plasma corticosterone levels at baseline, during the response and during the recovery phase. Response-level corticosterone was higher in females, and recovery from maximal level was faster than that of males. Selection did not affect baseline or stress-induced corticosterone levels, but it decreased the maximum corticosterone level in Aerobic and Predatory lines, reducing the difference between stress-induced and maximum levels. Recovery from restraint-induced corticosterone level tended to be slower in the Herbivorous than in the other lines, an effect that was stronger in females than in males. In conclusion, successful selection for increased performance in challenging conditions was not associated with changes in absolute values of the glucocorticoid response to stress, but can affect other characteristics of the glucocorticoid response curve.


Asunto(s)
Arvicolinae , Glucocorticoides , Animales , Corticosterona , Femenino , Masculino , Fenotipo , Sistema Hipófiso-Suprarrenal , Conducta Predatoria , Natación
5.
J Exp Biol ; 222(Pt 20)2019 10 18.
Artículo en Inglés | MEDLINE | ID: mdl-31548286

RESUMEN

The locomotor performance achieved in a challenging situation depends not only on physiological limitations, such as the aerobic exercise capacity, but also on behavioral characteristics, such as adequate coping with stress. The stress response is mediated largely by the hypothalamic-pituitary-adrenal (HPA) axis, through modulated release of glucocorticoids. We used a unique experimental evolution model system to test the hypothesis that the evolution of an increased aerobic exercise performance can be facilitated by modification of the glucocorticoid-related stress-coping mechanisms. Bank voles (Myodes glareolus) from 'aerobic' (A) lines, selected for 22 generations for high maximum swim-induced rate of oxygen consumption (V̇O2,swim), achieved a 64% higher V̇O2,swim than those from unselected, control lines. The temporal pattern of exercise during the swimming trial also evolved, and the A-line voles achieved V̇O2,swim later in the course of the trial, which indicates a modification of the stress response characteristics. Both V̇O2,swim and the average metabolic rate measured during the trial tended to increase with baseline corticosterone level, and decreased with the post-exercise corticosterone level. Thus, increased baseline corticosterone level promotes high metabolic performance, but a high corticosterone response to swimming acts as an inhibitor rather than stimulator of intense activity. However, neither of the corticosterone traits differed between the A-selected and control lines. Thus, the experiment did not provide evidence that evolution of increased aerobic performance is facilitated by the modification of glucocorticoid levels. The results, however, do not exclude the possibility that other aspects of the HPA axis function evolved in response to the selection.


Asunto(s)
Adaptación Psicológica , Arvicolinae/fisiología , Condicionamiento Físico Animal , Estrés Psicológico/fisiopatología , Animales , Metabolismo Basal , Peso Corporal , Corticosterona/metabolismo , Femenino , Masculino , Modelos Biológicos , Consumo de Oxígeno/fisiología
6.
Artículo en Inglés | MEDLINE | ID: mdl-31004810

RESUMEN

The maximum rate of aerobic exercise metabolism (VO2max) is a trait informative from both medical and evolutionary perspective, and both the physiological mechanisms limiting its level and its evolution are subject to vivid debate. Both comparative analyses and studies on the effects of training or acclimation to aerobically-demanding conditions suggest a role of oxygen transport-related properties of blood in limiting VO2max. Here we used a unique experimental evolution model - lines of bank voles selected for high rate of swim-induced aerobic metabolism (VO2swim; A lines), which evolved a 60% higher VO2swim than that observed in unselected control lines (C) - and asked how the hematological parameters evolved in response to the selection. Voles from the A lines had a decreased hemoglobin concentration in cardiac blood samples (adjusted means ±â€¯SE, A: 14.7 ±â€¯1.1, C: 15.3 ±â€¯1.1 g/dl; p = .008), hematocrit (A: 51.7 ±â€¯4.5, C: 53.8 ±â€¯4.2%; p = .042) and tended to have less erythrocytes per microliter of blood (A: 11.5 ±â€¯1.4, C: 12.7 ±â€¯1.3 mln/µl; p = .083). The effect of selection was more pronounced in males than in females. Thus, selection for high aerobic-exercise performance resulted in a paradoxical decrease in traits positively associated with oxygen-carrying capacity per unit of blood volume, and the effect was sex-dependent. However, as a decreased blood viscosity associated with the lowered hematocrit reduces the costs of blood circulation, it can be hypothesized that the change can actually boost the oxygen supply to peripheral tissues.


Asunto(s)
Arvicolinae/fisiología , Metabolismo Energético/genética , Condicionamiento Físico Animal , Selección Genética , Animales , Arvicolinae/genética , Respiración de la Célula/genética , Ejercicio Físico/fisiología , Femenino , Corazón/fisiología , Hemoglobinas/genética , Humanos , Masculino , Consumo de Oxígeno/genética , Natación/fisiología
7.
Inorganica Chim Acta ; 486: 529-537, 2019 Feb 24.
Artículo en Inglés | MEDLINE | ID: mdl-30804606

RESUMEN

Ligands that coordinate via dianionic phosphonate groups have not been widely utilized in radiopharmaceuticals. N-(phosphonomethyl)iminodiacetic acid (1, PMIDA) and N-(phosphonomethyl)glycine (2, PMG) were investigated as new chelators for the 99mTc/Re-tricarbonyl "core" (fac-M(CO)3, M = 99mTc, Re) present in a major class of radiopharmaceuticals. fac-M(CO)3(PMIDA) and fac-M(CO)3(PMG) complexes were studied by HPLC and 1H/13C/31P NMR methods for M = Re (Re-1 and Re-2) and by HPLC for M = 99mTc ( 99m Tc-1 and 99m Tc-2). Re-1 and 99m Tc-1 complexes exhibit a similar pH-dependent equilibrium between geometric linkage isomers (M-1a and M-1b). However, only one isomer exists for M-2 under all conditions. Structural characterization by X-ray crystallography reveals the presence of a bond between a phosphonate oxygen and the Re(I) center in fac-Re(CO)3(PMG) (Re-2). Detailed comparisons of NMR data for Re-2 conclusively demonstrate that the phosphonate group is coordinated in Re-1b (isomer favored at high pH) but not in Re-1a, which has a dangling N-(phosphonomethyl) group. To our knowledge, Re-1b and Re-2 and their 99mTc analogs are the first well-documented examples of complexes with these metal-tricarbonyl cores having a dianionic phosphonate group directly coordinated in a fac-M(CO)3-O-P grouping. Pharmacokinetic studies using Sprague-Dawley rats reveal that 99m Tc-2 is a robust tracer. Hence, phosphonate groups should be considered in designing 99mTc and 186/188Re radiopharmaceuticals, including agents with bioactive moieties attached to dangling carboxylate or phosphonate groups.

8.
Bioorg Med Chem Lett ; 25(11): 2335-9, 2015 Jun 01.
Artículo en Inglés | MEDLINE | ID: mdl-25908514

RESUMEN

To develop the first radiotracer targeting GPR91, a cell membrane-bound receptor that modulates the cellular response to hyperglycemia and hypoxia, we designed and prepared a small series of compounds based on a published series of 1,8-naphthyridines with high affinity to GPR91. Our approach provides a mechanism to incorporate radioactive atoms ((99m)Tc and (18)F) into the GPR91 pharmacophore as the final synthetic step. Pharmacological assays confirmed lead compounds for (99m)Tc and (18)F GPR91 radiotracers within the series.


Asunto(s)
Flúor/química , Naftiridinas/farmacocinética , Receptores Acoplados a Proteínas G/metabolismo , Tecnecio/química , Animales , Descubrimiento de Drogas , Radioisótopos de Flúor , Riñón/metabolismo , Estructura Molecular , Naftiridinas/química , Naftiridinas/farmacología , Trazadores Radiactivos , Ratas , Receptores Acoplados a Proteínas G/química
9.
Inorg Chem ; 54(13): 6281-90, 2015 Jul 06.
Artículo en Inglés | MEDLINE | ID: mdl-26068141

RESUMEN

We previously identified two new agents based on the [(99m)Tc(V)O](3+) core with renal clearances in human volunteers 30% higher than that of the widely used clinical tracer (99m)Tc-MAG3 (MAG3(5-) = penta-anion of mercaptoacetyltriglycine). However, renal agents with even higher clearances are needed. More recently, we changed our focus from the [(99m)Tc(V)O](3+) core to the discovery of superior tracers based on the fac-[(99m)Tc(I)(CO)3](+) core. Compared to (99m)Tc-MAG3, fac-[(99m)Tc(I)(CO)3(NTA)](2-) (NTA(3-) = trianion of nitrilotriacetic acid) holds great promise by virtue of its efficient renal clearance via tubular secretion and the absence of hepatobiliary elimination, even in patients with severely reduced renal function. We report here NMR, molecular (X-ray) structure, and solution data on fac-[Re(I)(CO)3(NTA)](2-) with a -CH2CO2(-) dangling monoanionic chain and on two fac-[Re(I)(CO)3(L)](-) analogues with either a -CH2CONH2 or a -CH2CH2OH dangling neutral chain. In these three fac-[Re(I)(CO)3(L)](n-) complexes, the fac-[Re(I)(CO)3(N(CH2CO2)2)](-) moiety is structurally similar and has similar electronic properties (as assessed by NMR data). In reported and ongoing studies, the two fac-[(99m)Tc(I)(CO)3(L)](-) analogues with these neutral dangling chains were found to have pharmacokinetic properties very similar to those of fac-[(99m)Tc(I)(CO)3(NTA)](2-). Therefore, we reach the unexpected conclusion that in fac-[(99m)Tc(I)(CO)3(L)](n-) agents, renal clearance is affected much more than anticipated by features of the core plus the chelate rings (the [(99m)Tc(I)(CO)3(N(CH2CO2)2)](-) moiety) than by the presence of a negatively charged dangling carboxylate chain.


Asunto(s)
Complejos de Coordinación/química , Modelos Moleculares , Ácido Nitrilotriacético/química , Compuestos de Organotecnecio/química , Fármacos Renales/química , Renio/química , Biomarcadores/análisis , Humanos , Espectroscopía de Resonancia Magnética , Estructura Molecular
10.
Small ; 10(3): 544-55, 2014 Feb 12.
Artículo en Inglés | MEDLINE | ID: mdl-24038985

RESUMEN

Despite advances in cancer diagnosis and treatment, ovarian cancer remains one of the most fatal cancer types. The development of targeted nanoparticle imaging probes and therapeutics offers promising approaches for early detection and effective treatment of ovarian cancer. In this study, HER-2 targeted magnetic iron oxide nanoparticles (IONPs) are developed by conjugating a high affinity and small size HER-2 affibody that is labeled with a unique near infrared dye (NIR-830) to the nanoparticles. Using a clinically relevant orthotopic human ovarian tumor xenograft model, it is shown that HER-2 targeted IONPs are selectively delivered into both primary and disseminated ovarian tumors, enabling non-invasive optical and MR imaging of the tumors as small as 1 mm in the peritoneal cavity. It is determined that HER-2 targeted delivery of the IONPs is essential for specific and sensitive imaging of the HER-2 positive tumor since we are unable to detect the imaging signal in the tumors following systemic delivery of non-targeted IONPs into the mice bearing HER-2 positive SKOV3 tumors. Furthermore, imaging signals and the IONPs are not detected in HER-2 low expressing OVCAR3 tumors after systemic delivery of HER-2 targeted-IONPs. Since HER-2 is expressed in a high percentage of ovarian cancers, the HER-2 targeted dual imaging modality IONPs have potential for the development of novel targeted imaging and therapeutic nanoparticles for ovarian cancer detection, targeted drug delivery, and image-guided therapy and surgery.


Asunto(s)
Diagnóstico por Imagen/métodos , Nanopartículas de Magnetita , Neoplasias Ováricas/diagnóstico , Receptor ErbB-2/metabolismo , Proteínas Recombinantes de Fusión , Animales , Línea Celular Tumoral , Femenino , Neoplasias de la Vesícula Biliar/diagnóstico , Neoplasias de la Vesícula Biliar/patología , Neoplasias de la Vesícula Biliar/secundario , Humanos , Ratones , Metástasis de la Neoplasia , Estadificación de Neoplasias , Imagen Óptica , Neoplasias Ováricas/patología , Sensibilidad y Especificidad
11.
J Magn Reson Imaging ; 40(5): 1071-81, 2014 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-25485347

RESUMEN

PURPOSE: The purpose of this study was to investigate an ultrashort echo time (UTE) imaging approach for improving the detection of receptor targeted magnetic nanoparticles in cancer xenograft models using positive contrast. MATERIALS AND METHODS: Iron oxide nanoparticle (IONP) conjugated with tumor targeting ligands were prepared. A 3D UTE gradient echo sequence with the shortest TE of 0.07 msec was evaluated on a 3T magnetic resonance imaging (MRI) scanner using IONP solution, cancer cells bound with targeted IONPs and orthotopic human pancreatic, and breast cancer mouse models administered tumor targeting IONPs. A simulation was performed to analyze contrast-to-noise ratios (CNR) of UTE images and subtraction of the images obtained UTE and longer TE (SubUTE). T2-weighted imaging and T2 relaxometry mapping were applied for comparison and validation. RESULTS: UTE and SubUTE images showed positive contrast in pancreatic tumors accumulated with EGFR targeted ScFvEGFR-IONPs and mammary tumors accumulated with uPAR targeted ATF-IONPs. The positive contrast observed in UTE images was consistent with the negative contrast observed in the T2-weighted images. A flip angle of 10° and a maximal possible TE for the second echo are suitable for SubUTE imaging. CONCLUSION: UTE imaging is capable of detecting tumor targeted IONPs in vivo with positive contrast in molecular MRI applications.


Asunto(s)
Medios de Contraste , Aumento de la Imagen/métodos , Interpretación de Imagen Asistida por Computador/métodos , Imagenología Tridimensional/métodos , Imagen por Resonancia Magnética/métodos , Nanopartículas de Magnetita , Neoplasias Mamarias Experimentales/diagnóstico , Imagen Molecular/métodos , Neoplasias Pancreáticas/diagnóstico , Animales , Femenino , Xenoinjertos , Humanos , Técnicas In Vitro , Ratones , Trasplante de Neoplasias , Fantasmas de Imagen , Sensibilidad y Especificidad
12.
Health Psychol Rep ; 12(2): 173-181, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-38628281

RESUMEN

BACKGROUND: Having a disabled sibling can be a source of extremely important and enriching experiences that foster the development of social and emotional competences, as well as broadening the child's perspective and knowledge. On the other hand, it also poses many challenges for the siblings, especially in adolescence. Thus, the aim of the proposed project is to investigate the specificity of the growing up process in young people with disabled siblings. PARTICIPANTS AND PROCEDURE: A total of 160 dyads (320 participants) - an adolescent and one of his/her parents - will take part in this cross-sectional case-control study. Participants will be assigned to four groups, having a sibling with: 1) intellectual disability, 2) motor disability, 3) chronic somatic disease, and 4) the control group - having a sibling without any disability. Both the healthy adolescent and one of the parents will fill out a set of questionnaires regarding the study variables: Questionnaire of Relationships with Siblings, Parental Attitude Scale-2, KidScreen-27, Parentification Questionnaire for Youth, Teenage Rebellion Questionnaire, Child Behavior Checklist 6-18. RESULTS: The primary outcomes include investigating the healthy adolescent functioning in three environments: family, peers and school. The proposed research model focuses both on the difficulties associated with having a disabled sibling (e.g. possible occurrence of disorders) and resources (e.g. higher quality of relationships in the family, especially in the sibling subsystem). CONCLUSIONS: The proposed comprehensive approach to the issue of disability in the family from the perspective of a healthy child will allow for a better understanding of the mechanisms underlying the process of growing up with disabled siblings.

13.
J Appl Genet ; 2024 Feb 10.
Artículo en Inglés | MEDLINE | ID: mdl-38340286

RESUMEN

This case study illustrates a multidisciplinary diagnostic and therapeutic model of care for a 7-year-old male with Lamb-Shaffer syndrome (LAMSHF). LAMSHF is an ultra-rare genetic neurodevelopmental disorder, caused by heterozygous alterations in the SOX5 gene. An integrative model of therapy of cognitive functions and speech is described. The presented approach allows the development of language competences through stimulation of basic cognitive functions, which allows the learning of the abstract rules of an inflected language. A surprising, unexpected improvement in the cognitive functioning of the child was observed (both in terms of reasoning and speech), as well as an increase in his independence. The clinically important problem of the need for continued stimulation of cognitive development, in spite of the unfavourable prognosis associated with LAMSHF, is highlighted.

14.
Nutrients ; 16(13)2024 Jun 28.
Artículo en Inglés | MEDLINE | ID: mdl-38999813

RESUMEN

This cross-sectional study conducted in Poland explored the relationship between the fear of negative appearance evaluations, eating disorders, and physical activity objectives, particularly during the COVID-19 pandemic. The Fear of Negative Appearance Evaluation Scale (FNAES), the Eating Attitude Test (EAT-26), and the Physical Activity Goals Inventory (IPAO) were administered to 644 participants (455 males with a mean age of 35.2 ± 6.2 years and 189 females with a mean age of 30.18 ± 5.7 years). This study explored the effects of gender, age, and body mass index (BMI) on FNAES, EAT-26, and IPAO scores. The results of this study demonstrated that females scored higher on fear of negative appearance, peaking at 41-50 years of age. Distinct BMI categories were associated with different negative appearance fear scores, eating attitudes, and physical activity objectives. Significant correlations were also found between the fear of negative appearance, dietary attitudes, and physical activity goals. Eating attitudes completely moderated the relationship between the fear of negative appearance and physical activity objectives. A significant interaction effect of age and body mass index on physical activity objectives was also revealed. These results highlight the relevance of considering gender, age, and body mass index when examining the associations between the fear of negative appearance, eating attitudes, and physical activity objectives.


Asunto(s)
Índice de Masa Corporal , COVID-19 , Ejercicio Físico , Miedo , SARS-CoV-2 , Humanos , COVID-19/psicología , COVID-19/prevención & control , COVID-19/epidemiología , Masculino , Femenino , Ejercicio Físico/psicología , Adulto , Estudios Transversales , Polonia , Conducta Alimentaria/psicología , Adulto Joven , Imagen Corporal/psicología , Persona de Mediana Edad , Trastornos de Alimentación y de la Ingestión de Alimentos/psicología , Encuestas y Cuestionarios , Factores Sexuales
15.
Heliyon ; 10(10): e31435, 2024 May 30.
Artículo en Inglés | MEDLINE | ID: mdl-38818196

RESUMEN

Background: Previous cross-sectional studies have found a beneficial relationship between greenspace and children's behaviour. Nevertheless, evidence on the mechanisms underlying this association remains scant. We examined whether the availability of greenspace was related to fewer behavioural problems in Polish children and investigated potential mechanisms. Methods: Data were obtained from the case-control NeuroSmog study, in which children with and without attention deficit hyperactivity disorder (ADHD) were tested from October 2020 to September 2022. The analytic sample comprised 679 children aged 10-13 years. Parents reported internalizing, externalizing, and total behavioural problems using the Child Behaviour Check List (CBCL), as well as information about the presence of a domestic garden and potential mediators: greenspace perception, neighbourhood social cohesion, and physical activity. Tree and grass covers were extracted in 500 m and 1 km buffers around lifelong residences. Structural equation modelling (SEM) was used to examine the psychosocial pathways linking the greenspace metrics to behavioural problems. Results: Greenspace was only indirectly related to fewer behavioural problems. Specifically, tree cover was related to greater levels of physical activity which, in turn, was related to fewer internalizing and total behavioural problems. Tree cover and presence of garden were related to greenspace perception which, in turn, was associated with higher neighbourhood social cohesion which, in turn, was linked to fewer behavioural problems. The patterns of associations in children without ADHD were very similar to those in the full sample except that the associations from garden to greenspace perception and from physical activity to total behavioural problems were no longer significant. The only association persisted among girls was from neighbourhood social cohesion to behavioural problems and among boys were from tree cover to physical activity and tree cover and garden to greenspace perception. Conclusion: Trees and garden, but not grass, are linked to fewer behavioural problems through greenspace perception, neighbourhood social cohesion, and physical activity in Polish children.

16.
J Xray Sci Technol ; 21(1): 43-52, 2013.
Artículo en Inglés | MEDLINE | ID: mdl-23507851

RESUMEN

PURPOSE: To demonstrate diffuse optical tomography (DOT) corrected fluorescence molecular tomography (FMT) for quantitatively imaging tumor-targeted contrast agents in a 4T1 mouse mammary tumor model. PROCEDURES: In the first set of experiments, we validated our DOT corrected FMT method using subcutaneously injected 4T1 cells pre-labeled with a near-infrared (NIR) Cy 5.5 dye labeled recombinant amino-terminal fragment (ATF) of the receptor binding domain of urokinase plasminogen activator (uPA), which binds to uPA receptor (uPAR) that is highly expressed in breast cancer tissues. Next, we apply the DOT corrected FMT method to quantitatively evaluate the ability of sensitive tumor imaging after systemic delivery of new uPAR-targeted optical imaging probes in the mice bearing 4T1 mammary tumors. These uPAR-targeted optical imaging probes are ATF peptides labeled with a newly developed NIR-830 dye being conjugated to magnetic iron oxide nanoparticles (IONPs). RESULTS: Our results have shown that DOT corrected FMT can accurately quantify and localize the injected imaging probe labeled 4T1 cells. Following systemic delivery of the targeted imaging nanoprobes into the mice bearing orthotopic mammary tumors, specific accumulation of the imaging probes in the orthotopic mammary tumors was detected in the mice that received uPAR targeted NIR-830-ATF-IONP probes but not in the mice injected with non-targeted NIR-830-mouse serum albumin (MSA)-IONPs. Additionally, DOT corrected FMT also enables the detection of both locally recurrent tumor and lung metastasis in the mammary tumor model 72 hrs after systemic administration of the uPAR-targeted NIR-830-labeled ATF peptide imaging probes. CONCLUSIONS: DOT corrected FMT and uPAR-targeted optical imaging probes have great potential for detection of breast cancer, recurrent tumor and metastasis in small animals.


Asunto(s)
Medios de Contraste/farmacocinética , Neoplasias Experimentales/patología , Imagen Óptica/métodos , Tomografía Óptica/métodos , Animales , Carbocianinas/química , Carbocianinas/farmacocinética , Línea Celular Tumoral , Medios de Contraste/química , Femenino , Colorantes Fluorescentes/química , Colorantes Fluorescentes/farmacocinética , Procesamiento de Imagen Asistido por Computador , Ratones , Ratones Endogámicos BALB C , Neoplasias Experimentales/metabolismo , Receptores del Activador de Plasminógeno Tipo Uroquinasa/metabolismo , Activador de Plasminógeno de Tipo Uroquinasa/química , Activador de Plasminógeno de Tipo Uroquinasa/metabolismo , Activador de Plasminógeno de Tipo Uroquinasa/farmacocinética , Imagen de Cuerpo Entero/métodos
17.
Percept Mot Skills ; 130(2): 714-731, 2023 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-36779276

RESUMEN

Our main aim in this study was to investigate cognitive functioning in young gymnasts. The study group consisted of 86 children, aged 10-12 years: (a) a criterion group of 41 juvenile athletes (Mage = 11.23; SDage = 0.93) who trained six times per week; and (b) a comparison group of 45 children (Mage = 11.11; SDage = 0.61) who were not involved competitively in sports but who were mostly quite physically active. We measured attention, memory processes, and bioelectrical brain activity in the central region (Cz; where there are connections to motor control, movement, and sensation). We found significant differences between our two participant groups in short-term memory, deferred naming memory, and long-term memory of visual material. Children who practiced gymnastics had a better attention span than those who did not, and children who were non-athletes but who undertook physical activity more frequently than five times per week had a different theta/sensory motor rhythm (SMR) brain wave ratio (with SMR higher), meaning that they felt calmer and more relaxed.


Asunto(s)
Cognición , Gimnasia , Niño , Humanos , Ejercicio Físico , Atletas , Encéfalo
18.
Front Public Health ; 11: 1170413, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-37465176

RESUMEN

Introduction: Parents' supportiveness and health-promoting habits significantly affect the intensity of children's physical activity (PA) and the involvement of parents in their engagement in PA; in this domain, both the hours devoted to PA and PA goals can be assessed. The family plays an important role in shaping the physical and social organization of the environment for children aged 4-6 years. Methods: A total of 680 families with 5-year-old children (330 girls, 350 boys) took part in the study. Data were collected from these participants, who were recruited from preschools and primary schools in the Pomeranian region of Poland. The aim of this study was to determine whether the involvement of parents in PA mediates the influence of parental attitudes on the ways in which their children spend their leisure time. Results: The results showed that not all parental attitudes had direct impact on children's leisure time in PA and outside PA. Other aspects parental attitude had no significant impact on offspring's free time. Among fathers, only four aspects of parental attitude (namely, acceptance-rejection, inconsistency, autonomy, and overprotectiveness) had an impact on PA goals. Mothers' goals were influenced by the strength of a larger number of aspects of attitude (namely, acceptance-rejection, autonomy, inconsistency, over-demandingness, and overprotectiveness). Similarly, the strength of mothers' and fathers' acceptance-rejection attitudes, attitudes of autonomy, and overprotectiveness had an impact on their PA goals but were not directly linked to their children's leisure-time engagement in PA. Discussion: Not all parental attitudes have a direct impact on children's PA or non-PA leisure time. However, the goals of PA parents have been recognized influence the leisure time of children in PA and outside PA. The most statistically significant relationship for both mothers and fathers was between parental attitudes and PA goals. Parental attitudes do not play a significant role in explaining involvement in PA or lack of it in leisure time among 5-year-old children.


Asunto(s)
Objetivos , Relaciones Padres-Hijo , Niño , Masculino , Femenino , Preescolar , Humanos , Padres , Ejercicio Físico , Actividades Recreativas , Actitud
19.
Front Psychiatry ; 14: 1171489, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-37415696

RESUMEN

Objective: Based on the theory of Job Demands-Resources, this study has been set out to examine how parenting demands, parenting resources affect parental burnout of primary school students' parents. Methods: An online survey with four scales (Parenting Stress Scale, Perceived Family Support Scale, Psychological Resilience Scale and Parental Burnout Scale) was completed by 600 parents of students from three primary schools in Central China. Structural equation models were implemented. Results: Parenting stress had a positive impact on parental burnout (ß = 0.486, p < 0.001). Both perceived family support (ß = -0.228, p < 0.001) and psychological resilience (ß = -0.332, p = 0.001) had a negative impact on parental burnout. Perceived family support played a moderating role between parenting stress and parental burnout (ß = -0.121, p < 0.001). Psychological resilience also played a moderating role between parenting stress and parental burnout (ß = -0.201, p < 0.001). Psychological resilience partially mediated the relationship between perceived family support and parental burnout. The total effect was -0.290, with 95% CI (-0.350, -0.234). Direct effect was -0.228, with 95% CI (-0.283, -0.174), and indirect effect was -0.062, with 95% CI (-0.092, -0.037). Conclusion: Parental burnout may be reduced by increasing family support and self-improvement of psychological resilience. In the same way, the impact of parenting stress on parental burnout may be buffered under high-pressure situations.

20.
Int J Public Health ; 68: 1604777, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-37325173

RESUMEN

Objectives: Sensation seeking (SS) is associated with engaging in risk behaviors and it is also positively correlated with engaging in physical activity and building beneficial personality resources for coping processes. This study investigates the role of SS in building resiliency and the risk of tobacco and alcohol use. Methods: A total of 649 adolescents, who either practice or do not practice sports, took part in this study. Participants completed a set of questionnaires which verify level of: SS, resiliency, tobacco and alcohol use. Results: No statistically significant gender- or sports-related differences were observed on the tobacco and alcohol use, as well as for SS according to the ANOVA results. Furthermore, mediation analysis showed that the effect of SS on tobacco and alcohol use through resiliency was significant for the female PE and the male athlete group. Conclusion: Higher influence of SS on resiliency was noted in the male athlete group, and in this case resiliency was a factor protecting against tobacco use. Engaging in sports fosters resiliency, the mechanisms underlying the development of resiliency seem to be aided by SS.


Asunto(s)
Deportes , Adolescente , Humanos , Masculino , Femenino , Consumo de Bebidas Alcohólicas/epidemiología , Asunción de Riesgos , Sensación
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA