Detalles de la búsqueda
1.
Selective Estrogen Receptor Modulators Enhance CNS Remyelination Independent of Estrogen Receptors.
J Neurosci
; 39(12): 2184-2194, 2019 03 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-30696729
2.
Discovery of potent and selective PPARα/δ dual antagonists and initial biological studies.
Bioorg Med Chem Lett
; 29(3): 503-508, 2019 02 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30594433
3.
Identification of the Kappa-Opioid Receptor as a Therapeutic Target for Oligodendrocyte Remyelination.
J Neurosci
; 36(30): 7925-35, 2016 07 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-27466337
4.
Identification of the first potent, selective and bioavailable PPARα antagonist.
Bioorg Med Chem Lett
; 24(10): 2267-72, 2014 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24745969
5.
Identification and In Vivo Evaluation of Myelination Agent PIPE-3297, a Selective Kappa Opioid Receptor Agonist Devoid of ß-Arrestin-2 Recruitment Efficacy.
ACS Chem Neurosci
; 15(3): 685-698, 2024 Feb 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-38265210
6.
Discovery of a brain penetrant small molecule antagonist targeting LPA1 receptors to reduce neuroinflammation and promote remyelination in multiple sclerosis.
Sci Rep
; 14(1): 10573, 2024 05 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-38719983
7.
DP2 (CRTh2) antagonism reduces ocular inflammation induced by allergen challenge and respiratory syncytial virus.
Int Arch Allergy Immunol
; 157(3): 259-68, 2012.
Artículo
en Inglés
| MEDLINE | ID: mdl-22042170
8.
Amelioration of dermal fibrosis by genetic deletion or pharmacologic antagonism of lysophosphatidic acid receptor 1 in a mouse model of scleroderma.
Arthritis Rheum
; 63(5): 1405-15, 2011 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-21305523
9.
Previous exposure to delta9-tetrahydrocannibinol enhances locomotor responding to but not self-administration of amphetamine.
J Pharmacol Exp Ther
; 337(3): 724-33, 2011 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-21389094
10.
Pharmacology of AM211, a potent and selective prostaglandin D2 receptor type 2 antagonist that is active in animal models of allergic inflammation.
J Pharmacol Exp Ther
; 338(1): 290-301, 2011 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-21487069
11.
Discovery and optimization of a biphenylacetic acid series of prostaglandin D2 receptor DP2 antagonists with efficacy in a murine model of allergic rhinitis.
Bioorg Med Chem Lett
; 21(21): 6608-12, 2011 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21958540
12.
Sodium [2'-[(cyclopropanecarbonyl-ethyl-amino)-methyl]-4'-(6-ethoxy-pyridin-3-yl)-6-methoxy-biphenyl-3-yl]-acetate (AM432): a potent, selective prostaglandin D2 receptor antagonist.
Bioorg Med Chem Lett
; 21(3): 1036-40, 2011 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21211969
13.
Discovery of PIPE-359, a Brain-Penetrant, Selective M1 Receptor Antagonist with Robust Efficacy in Murine MOG-EAE.
ACS Med Chem Lett
; 12(1): 155-161, 2021 Jan 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-33488977
14.
Pharmacological blockade of the DP2 receptor inhibits cigarette smoke-induced inflammation, mucus cell metaplasia, and epithelial hyperplasia in the mouse lung.
J Pharmacol Exp Ther
; 332(3): 764-75, 2010 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-19996299
15.
5-Lipoxygenase-activating protein inhibitors. Part 3: 3-{3-tert-Butylsulfanyl-1-[4-(5-methoxy-pyrimidin-2-yl)-benzyl]-5-(5-methyl-pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM643)-A potent FLAP inhibitor suitable for topical administration.
Bioorg Med Chem Lett
; 20(15): 4598-601, 2010 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20566292
16.
5-Lipoxygenase-activating protein inhibitors. Part 2: 3-{5-((S)-1-Acetyl-2,3-dihydro-1H-indol-2-ylmethoxy)-3-tert-butylsulfanyl-1-[4-(5-methoxy-pyrimidin-2-yl)-benzyl]-1H-indol-2-yl}-2,2-dimethyl-propionic acid (AM679)--a potent FLAP inhibitor.
Bioorg Med Chem Lett
; 20(1): 213-7, 2010 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19914828
17.
Pharmacological characterization of 3-[3-tert-butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM103), a novel selective 5-lipoxygenase-activating protein inhibitor that reduces acute and chronic inflammation.
J Pharmacol Exp Ther
; 331(3): 1042-50, 2009 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-19749079
18.
Novel tricyclic antagonists of the prostaglandin D2 receptor DP2 with efficacy in a murine model of allergic rhinitis.
Bioorg Med Chem Lett
; 19(16): 4647-51, 2009 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19608418
19.
Distribution of metabotropic glutamate 2 and 3 receptors in the rat forebrain: Implication in emotional responses and central disinhibition.
Brain Res
; 1197: 47-62, 2008 Mar 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-18242587
20.
In vitro and in vivo pharmacology of NXT629, a novel and selective PPARα antagonist.
Eur J Pharmacol
; 809: 130-140, 2017 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28483457