RESUMEN
Deterministic approximations to stochastic Susceptible-Infectious-Susceptible models typically predict a stable endemic steady-state when above threshold. This can be hard to relate to the underlying stochastic dynamics, which has no endemic steady-state but can exhibit approximately stable behaviour. Here, we relate the approximate models to the stochastic dynamics via the definition of the quasi-stationary distribution (QSD), which captures this approximately stable behaviour. We develop a system of ordinary differential equations that approximate the number of infected individuals in the QSD for arbitrary contact networks and parameter values. When the epidemic level is high, these QSD approximations coincide with the existing approximation methods. However, as we approach the epidemic threshold, the models deviate, with these models following the QSD and the existing methods approaching the all susceptible state. Through consistently approximating the QSD, the proposed methods provide a more robust link to the stochastic models.
Asunto(s)
Enfermedades Transmisibles , Epidemias , Enfermedades Transmisibles/epidemiología , Humanos , Conceptos Matemáticos , Modelos Biológicos , Procesos EstocásticosRESUMEN
Qualitative research and comprehensive public awareness to nip the transmission of Ebola virus in the bud before it becomes a global threat is fast becoming imperative especially now that the Gambia Ebola virus is mutated. It is therefore necessary to consider and investigate a vector-host transmission model for possible control strategy of this deadly disease. Hence, in this study, we presented a novel and feasible human-bat (host-vector) S h E h I h R h i s R h n i - S b E b I b model which foretells the spread and severity of the Ebola virus from bats to humans to investigate the combined effects of three control strategies viz: (1) allowing specialized and designated agencies to bury deceased from Ebola infection without relatives touching or curdling the remains as usually practiced in most part of Africa as last respect for their departed love ones ( k 1 ), (2) systematic and deliberate depopulation of bats in the metropolis (through persecution with pesticide exposure, pre capturing, chemical timber treatment for roosts destruction) to discourage hunting them for food by virtue of their proximity ( k 2 ) and (3) immediate treatment of infected individuals in isolation ( k 3 ). We established, among others, the endemic equilibrium, disease-free equilibrium, global and local stability, non-negativity, and boundedness of the model to prove the epidemiological feasibility of the model. The reality of the presence of optimal control remarkably influences the dynamics of transmission of the virus and simulated results also confirm the great effect of the combination of the control strategies k 1 , k 2 and k 3 in flattening the curve of Ebola transmission (fig 1 - fig 8). Health workers and policy makers are better informed with fundamental precautions that could help eradicate Ebola from the populace.
RESUMEN
In this research, an unrivalled hybrid scheme which involves the coupling of the new Elzaki integral transform (an improved version of Laplace transform) and a modified differential transform called the projected differential transform (PDTM) have been implemented to solve the generalized Burgers-Fisher's equation; which springs up due to the fusion of the Burgers' and the Fisher's equation; describing convective effects, diffusion transport or interaction between reaction mechanisms, traffic flows; and turbulence; consequently finding meaningful applicability in the applied sciences viz: gas dynamics, fluid dynamics, turbulence theory, reaction-diffusion theory, shock-wave formation, traffic flows, financial mathematics, and so on. Using the proposed Elzaki projected differential transform method (EPDTM), a generalized exact solution (Solitary solution) in form of a Taylor multivariate series has been obtained; of which the highly nonlinear terms and derivatives handled by PDTM have been decomposed without expansion, computation of Adomian or He's polynomials, discretization, restriction of parameters, and with less computational work whilst achieving a highly convergent results when compared to other existing analytical/exact methods in the literature, via comparison tables, 3D plots, convergence plots and fluid-like plots. Thus showing the distinction, novelty and huge advantage of the proposed method as an asymptotic alternative, in providing generalized or solitary wave solution to a wider class of differential equations.