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Emerg Infect Dis ; 27(1): 196-204, 2021 01.
Artículo en Inglés | MEDLINE | ID: mdl-33350913

RESUMEN

Initial cases of coronavirus disease in Hong Kong were imported from mainland China. A dramatic increase in case numbers was seen in February 2020. Most case-patients had no recent travel history, suggesting the presence of transmission chains in the local community. We collected demographic, clinical, and epidemiologic data from 50 patients, who accounted for 53.8% of total reported case-patients as of February 28, 2020. We performed whole-genome sequencing to determine phylogenetic relationship and transmission dynamics of severe acute respiratory syndrome coronavirus 2 infections. By using phylogenetic analysis, we attributed the community outbreak to 2 lineages; 1 harbored a common mutation, Orf3a-G251V, and accounted for 88.0% of the cases in our study. The estimated time to the most recent common ancestor of local coronavirus disease outbreak was December 24, 2019, with an evolutionary rate of 3.04 × 10-3 substitutions/site/year. The reproduction number was 1.84, indicating ongoing community spread.


Asunto(s)
COVID-19/epidemiología , COVID-19/virología , Brotes de Enfermedades , Adulto , Anciano , Anciano de 80 o más Años , COVID-19/transmisión , Análisis por Conglomerados , Punto Alto de Contagio de Enfermedades , Evolución Molecular , Femenino , Hong Kong/epidemiología , Humanos , Masculino , Persona de Mediana Edad , Mutación , Filogenia , Filogeografía , SARS-CoV-2/genética , SARS-CoV-2/aislamiento & purificación , Proteínas Viroporinas/genética , Secuenciación Completa del Genoma , Adulto Joven
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