1.
Org Biomol Chem
; 10(25): 4933-42, 2012 Jul 07.
Artículo
en Inglés
| MEDLINE
| ID: mdl-22614284
RESUMEN
The design, synthesis and biological evaluation of a novel C,D-spirolactone analogue of paclitaxel is described. This is the first paclitaxel analogue without an oxetane D-ring that shows a significant cytotoxic effect (activity one order of magnitude lower than paclitaxel). More importantly, its cytotoxicity is a result of a different mechanism of action, involving mTOR inhibition-dependent autophagy instead of G(2)/M cell cycle arrest-dependent apoptosis.