Asunto(s)
Feto/irrigación sanguínea , Ultrasonografía Prenatal/métodos , Malformaciones de la Vena de Galeno/diagnóstico por imagen , Malformaciones de la Vena de Galeno/embriología , Aborto Eugénico , Adulto , Circulación Cerebrovascular , Femenino , Feto/anomalías , Feto/diagnóstico por imagen , Humanos , Ilustración Médica , Arteria Cerebral Media/diagnóstico por imagen , Arteria Cerebral Media/embriología , Embarazo , Pronóstico , MortinatoRESUMEN
BACKGROUND: Myelin oligodendrocyte glycoprotein (MOG) may be implicated in the immunopathogenesis of multiple sclerosis (MS) inducing demyelination in the animal model of MS. In adults reported anti-MOG antibody frequencies have been variable across a number of studies and can also be detected in controls. OBJECTIVE: To measure antibodies against MOG in paediatric patients with demyelinating disorders of the central nervous system and in controls. METHODS: Serum antibodies against MOG and myelin basic protein were measured by ELISA, flow cytometry (FACS) and in the liquid phase in 11 children with acute disseminated encephalomyelitis (ADEM), 22 children with MS, seven children with acute viral encephalitis and 13 healthy controls. The serostatus of Epstein-Barr virus (EBV) infections were assessed. RESULTS: Anti-MOG antibodies, measured either by ELISA or FACS were exclusively detected in children with demyelination. In ADEM these antibodies were highly reactive. Anti-MBP reactivity was detectable equally in all groups. The presence of either autoantibodies did not associate with EBV serostatus, age, gender or disease course. CONCLUSIONS: This study independently corroborates recently published results of seroprevalence and specificity of the assay. Due to their low sensitivity anti-MOG antibodies will not serve as disease-specific biomarkers, but could help to support the diagnosis of ADEM in difficult cases.
Asunto(s)
Autoanticuerpos/sangre , Enfermedades Desmielinizantes/diagnóstico , Encefalitis Viral/diagnóstico , Encefalomielitis Aguda Diseminada/diagnóstico , Glicoproteína Asociada a Mielina/inmunología , Adolescente , Biomarcadores/sangre , Distribución de Chi-Cuadrado , Niño , Preescolar , Enfermedades Desmielinizantes/inmunología , Diagnóstico Diferencial , Encefalitis Viral/inmunología , Encefalomielitis Aguda Diseminada/inmunología , Ensayo de Inmunoadsorción Enzimática , Infecciones por Virus de Epstein-Barr/diagnóstico , Infecciones por Virus de Epstein-Barr/inmunología , Femenino , Citometría de Flujo , Francia , Alemania , Humanos , Inmunidad Humoral , Masculino , Proteína Básica de Mielina , Proteínas de la Mielina , Glicoproteína Mielina-Oligodendrócito , Proteínas del Tejido Nervioso/inmunología , Valor Predictivo de las Pruebas , Estudios Retrospectivos , Factores de Transcripción/inmunologíaRESUMEN
Pediatric MS is better understood after a series of epidemiological studies including the French cohort following almost 500 children since more than 7 years. Pediatric MS may have an onset as early as 2 years but symptoms are different than those at adolescence. Its evolution towards a motor handicap is slower than in adults but cognitive impairment have to be evaluated carefully. Interferon beta treatment can be use, if needed, even before the age of 10. Several environmental factors might increase its risk, especially early EBV infection or passive smoking. HBV vaccination does not increase significantly its risk of occurrence.
Asunto(s)
Esclerosis Múltiple/terapia , Adolescente , Encéfalo/patología , Niño , Preescolar , Estudios de Cohortes , Progresión de la Enfermedad , Francia/epidemiología , Humanos , Esclerosis Múltiple/epidemiología , Esclerosis Múltiple/patología , Esclerosis Múltiple/fisiopatologíaRESUMEN
OBJECTIVES: Neurological causes are common diagnoses for apparent life-threatening events in infants. The objective of this study was to evaluate the relevancy of electroencephalography performed after an apparent life-threatening event. MATERIAL AND METHODS: A retrospective study was conducted in a children's hospital over a 1-year period. The charts of infants under 2 years of age who were admitted following an apparent life-threatening event were reviewed. Clinical and biological data were collected and electroencephalograms - divided into normal and abnormal - were reviewed. To evaluate the follow-up state of the patients, parents were invited to complete an evaluation form an average 13 months after the event. The yield for electroencephalography was established according to the ratio of positive results contributing to the diagnosis of the cause of the apparent life-threatening event. RESULTS: A total of 47 patients met the inclusion criteria. Fifteen had had an EEG, 32 had not. The rate of abnormal neurological signs described by parents during the apparent life-threatening event was higher in the EEG group compared to the group without EEG (53% vs. 22%, P=0.05). In the follow-up, 35% of the children presented a second event, which was described as being similar or less impressive and occurred in the 1st month after the event (91%). Of the eight abnormal electroencephalograms, six had no specific abnormalities and two contributed to the diagnosis of epileptic seizure. Therefore, the diagnostic yield of electroencephalography in this study was 13% (2/8). CONCLUSIONS: The yield of electroencephalography performed after an apparent life-threatening event is low. Neurological history and repeated physical examinations still remain the major diagnostic tools before resorting to electroencephalography.