RESUMEN
Coronavirus disease 2019 is responsible for a global pandemic and has impacted health care accessibility and delivery. Clinic data were reviewed for an STI clinic from September 2019 to May 2020. A significant decrease in rates of STI visits and treatments during the coronavirus disease 2019 pandemic was observed.
Asunto(s)
Instituciones de Atención Ambulatoria/estadística & datos numéricos , Atención Ambulatoria/estadística & datos numéricos , COVID-19/epidemiología , Accesibilidad a los Servicios de Salud/estadística & datos numéricos , Enfermedades de Transmisión Sexual/epidemiología , Humanos , Pandemias , Rhode Island , Enfermedades de Transmisión Sexual/prevención & controlRESUMEN
Coronavirus disease (COVID-19) is responsible for a global pandemic. It is important to balance the need for access to healthcare services, including testing and treatment for sexually transmitted infections. Sexually transmitted infection programs must consider how to use limited resources and implement novel approaches to provide continued access to care.
Asunto(s)
Instituciones de Atención Ambulatoria/provisión & distribución , Infecciones por Coronavirus/epidemiología , Accesibilidad a los Servicios de Salud/organización & administración , Neumonía Viral/epidemiología , Servicios de Salud Reproductiva/provisión & distribución , Enfermedades de Transmisión Sexual , Betacoronavirus , COVID-19 , Infecciones por Coronavirus/complicaciones , Infecciones por Coronavirus/virología , Humanos , Pandemias , Neumonía Viral/complicaciones , Neumonía Viral/virología , SARS-CoV-2 , Enfermedades de Transmisión Sexual/virologíaRESUMEN
BACKGROUND: Treponema-specific assays are widely adopted in the first step of the reverse algorithm of serologic syphilis screening. The new BioPlex 2200 Syphilis Total and rapid plasma reagin (RPR) test is designed to perform the first 2 steps of the algorithm simultaneously. However, limited data regarding the BioPlex Syphilis Total and RPR in clinical practice exist. METHODS: A total of 293 random samples at a tertiary medical center were tested by BioPlex Syphilis Total and RPR, BioPlex Syphilis IgG, Architect Syphilis TP, and BD Macro-Vue RPR card. Treponema pallidum particle agglutination (TP-PA) assay and clinical chart review were used to resolve discrepancies. Comparisons were performed among treponemal-specific assays and between 2 RPR tests. RESULTS: Good overall agreements (>91%) were achieved between BioPlex Syphilis Total, BioPlex Syphilis IgG, and Architect Syphilis TP. Overall agreement between BioPlex RPR and BD RPR was 86.8% with positive percent agreement of 66.7% and negative percent agreement of 96.3%. There were 37 discordant samples including 30 with BD RPR+/BioPlex RPR- and 7 with BD RPR-/BioPlex RPR+. Negative BioPlex RPR results were observed in samples with reactive BD RPR: 10 (91%) of 11 for BD RPR 1:1, 13 (65%) of 20 for BD RPR 1:2, 6 (35%) of 17 for BD RPR 1:4, and 1 (7%) of 14 for BD RPR 1:8. The discordant samples were predominantly from patients with high-risk of syphilis reinfection and included 9 patients with an early reinfection. CONCLUSIONS: Our results demonstrated that BioPlex Syphilis Total and Architect Syphilis TP performed similarly. The BioPlex RPR missed a small number of early syphilis reinfections, and its implementation should depend on the patient population that the laboratory serves.
Asunto(s)
Serodiagnóstico de la Sífilis/métodos , Sífilis/diagnóstico , Treponema pallidum/aislamiento & purificación , Anticuerpos Antibacterianos , Humanos , Inmunoensayo/métodos , Valor Predictivo de las Pruebas , Reaginas/sangre , Reproducibilidad de los Resultados , Sensibilidad y Especificidad , Sífilis/sangre , Sífilis/epidemiología , Treponema pallidum/inmunología , Estados UnidosRESUMEN
BACKGROUND: Medicaid expansion has led to unique opportunities for sexually transmitted disease (STD) clinics to improve the sustainability of services by billing insurance. We evaluated changes in patient visits after the implementation of insurance billing at a STD clinic in a Medicaid expansion state. METHODS: The Rhode Island STD Clinic offered HIV/STD screening services at no cost to patients until October 2016, when insurance billing was implemented. Care for uninsured patients was still provided for free. We compared the clinic visits in the preinsurance period with the postinsurance period using t-tests, Poisson regressions, and a logistic regression. RESULTS: A total of 5560 patients were seen during the preinsurance (n = 2555) and postinsurance (n = 3005) periods. Compared with the preinsurance period, the postinsurance period had a significantly higher average number of patient visits/month (212.9 vs. 250.4, P = 0.0016), including among patients who were black (36.8 vs. 50.3, P = 0.0029), Hispanic/Latino (50.8 vs. 65.8, P = 0.0018), and insured (106.3 vs. 130.1, P = 0.0025). The growth rate of uninsured (+0.10 vs. +4.11, P = 0.0026) and new patients (-4.28 vs. +1.07, P = 0.0007) also increased between the two periods. New patients whose first visit was before the billing change had greater odds (adjusted odds ratio, 2.68, 95% confidence interval, 2.09-3.44; P < 0.0001) of returning compared with new patients whose first visit was after the billing change. CONCLUSIONS: Implementation of insurance billing at a publicly funded STD clinic, with free services provided to uninsured individuals, was associated with a modest increase in patient visits and a decline in patients returning for second visits.
Asunto(s)
Atención Ambulatoria/estadística & datos numéricos , Accesibilidad a los Servicios de Salud/economía , Cobertura del Seguro/estadística & datos numéricos , Seguro de Salud/estadística & datos numéricos , Medicaid/estadística & datos numéricos , Atención Ambulatoria/psicología , Instituciones de Atención Ambulatoria/estadística & datos numéricos , Femenino , Costos de la Atención en Salud/estadística & datos numéricos , Implementación de Plan de Salud/economía , Implementación de Plan de Salud/estadística & datos numéricos , Humanos , Cobertura del Seguro/economía , Seguro de Salud/economía , Masculino , Minorías Sexuales y de Género/estadística & datos numéricos , Enfermedades de Transmisión Sexual/prevención & control , Estados UnidosAsunto(s)
Prueba de COVID-19 , COVID-19/diagnóstico , Accesibilidad a los Servicios de Salud , Disparidades en el Estado de Salud , Disparidades en Atención de Salud , Enfermedades de Transmisión Sexual/diagnóstico , Determinantes Sociales de la Salud , Negro o Afroamericano , COVID-19/prevención & control , Hispánicos o Latinos , Humanos , Salud Pública , Mejoramiento de la Calidad , SARS-CoV-2 , Minorías Sexuales y de Género , Enfermedades de Transmisión Sexual/terapiaRESUMEN
BACKGROUND: Vaccines are effective in preventing Coronavirus Disease 2019 (COVID-19). Vaccine hesitancy defined as delay of acceptance or refusal of the vaccine is a major barrier to effective implementation. METHODS: Participants were recruited statewide through an English and Spanish social media marketing campaign conducted by a local news station during a one-month period as vaccines were becoming available in Rhode Island (from December 21, 2020 to January 22, 2021). Participants completed an online survey about COVID-19 vaccines and vaccine hesitancy with constructs and items adopted from the Health Belief Model. RESULTS: A total of 2,007 individuals completed the survey. Eight percent (n = 161) reported vaccine hesitancy. The sample had a median age of 58 years (interquartile range [IQR]: 45, 67), were majority female (78%), White (96%), Non-Hispanic (94%), employed (58%), and reported an annual individual income of $50,000 (59%). COVID-19 vaccine hesitancy was associated with attitudes and behaviors related to COVID-19. A one unit increase in concern about COVID-19 was associated with a 69% (Adjusted Odds Ratio: 0.31, 95% CI: 0.26-0.37) decrease in vaccine hesitancy. A one-level increase in the likelihood of getting influenza vaccine was associated with a 55% (AOR: 0.45 95% CI: 0.41-0.50) decrease in vaccine hesitancy. CONCLUSIONS: COVID-19 vaccine hesitancy was relatively low in a state-wide survey in Rhode Island. Future research is needed to better understand and tailor messaging related to vaccine hesitancy.
Asunto(s)
COVID-19 , Vacunas contra la Influenza , Anomalías Urogenitales , COVID-19/epidemiología , COVID-19/prevención & control , Vacunas contra la COVID-19 , Femenino , Humanos , Persona de Mediana Edad , Aceptación de la Atención de Salud , Rhode Island/epidemiología , Vacilación a la VacunaciónRESUMEN
BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its associated disease (COVID-19) are a significant cause of morbidity and mortality across the United States. Internal medicine (IM) residents are a critical component of the healthcare workforce yet their seroprevalence of SARS-CoV-2 antibodies is largely unknown. The aim of this research was to ascertain the seroprevalences of SARS-CoV-2 among internal medicine residents during the first peak of COVID-19. METHODS: IM residents were enrolled in a surveillance program that included PCR and antibody testing for SARS-CoV-2 in June 2020. Residents also completed a short questionnaire to obtain sociodemographic information and characterize potential workplace exposure to COVID-19. RESULTS: A total of 101 IM residents participated in the study (out of N=162). Of the 101 samples, three (2.9%) tested positive for SARS-CoV-2 antibodies. No residents tested PCR positive for SARS-CoV-2. DISCUSSION: The implementation of COVID-19 patient cohorting and the incorporation of telemedicine to communicate with hospitalized patients into clinical practice early in the pandemic may have prevented the spread of the virus among the surveyed clinical trainees. CONCLUSION: Despite significant engagement with COVID-19 patients, IM residents demonstrated a low rate of SARS-CoV-2 seroprevalence.
Asunto(s)
COVID-19/epidemiología , Medicina Interna/educación , Internado y Residencia , Adulto , Anticuerpos Antivirales/sangre , Biomarcadores/sangre , COVID-19/sangre , COVID-19/diagnóstico , COVID-19/transmisión , Prueba de COVID-19 , Femenino , Humanos , Transmisión de Enfermedad Infecciosa de Paciente a Profesional , Masculino , Exposición Profesional , Prevalencia , Rhode Island/epidemiología , Factores de Riesgo , SARS-CoV-2/inmunología , Estudios SeroepidemiológicosRESUMEN
The number of people diagnosed with syphilis has increased significantly in the United States over the last decade. In Rhode Island, the number of new diagnoses has increased more than four-fold since 2008. Syphilis disproportionately impacts gay, bisexual, and other men who have sex with men (MSM), with those from African American and Hispanic/Latino communities most affected. Given these trends, physicians need to be aware of current prevention, diagnosis, and treatment practices for syphilis, especially when working with populations who are most at risk. [Full article available at http://rimed.org/rimedicaljournal-2019-02.asp].
Asunto(s)
Etnicidad/estadística & datos numéricos , Atención Primaria de Salud , Minorías Sexuales y de Género/estadística & datos numéricos , Sífilis/epidemiología , Adulto , Etnicidad/educación , Femenino , Conocimientos, Actitudes y Práctica en Salud , Humanos , Masculino , Educación del Paciente como Asunto , Rhode Island/epidemiología , Minorías Sexuales y de Género/educación , Sífilis/prevención & control , Adulto JovenRESUMEN
United States guidelines endorse one-time HCV antibody screening at HIV diagnosis. Rescreening HCV-seronegative patients on a regular basis is still not policy, although HIV-infected persons have reasonably substantial HCV incidence. We evaluated routine risk factor-independent HCV antibody re-testing in a Rhode Island HIV clinic. We instituted annual HCV antibody testing for HCV-seronegative patients who had not been rescreened in a year or more. Testing based on clinical suspicion continued. We conducted a chart review of new antibody-positive cases in the first year of rescreening, July 2006 to June 2007. Of 245 rescreened patients, 11 (4.5%) seroconverted. Five (45%) were female. Median time between last negative and first positive result was 32 months (range 8-98 months). Six (55%) had documented risk factors and 6 (55%) elevated ALT (> 45 IU/L) between antibody tests; none prompted re-testing. One seroconverter died of hepatocellular carcinoma 3.7 years after HCV diagnosis. A twelfth was rescreened for suspected acute HCV based on ALT of 515 IU/L. He had newly detectable HCV RNA then seroconversion, and achieved SVR following 6 months of treatment in the acute phase for genotype 1 infection. Incident HCV is not uncommon among HIV-infected patients in care. Rescreening identified undiagnosed HCV in this population. HCV RNA should be checked promptly in HCV-seronegative persons with ALT elevation. We observed consequences of late diagnosis (hepatocellular carcinoma) and benefits of early diagnosis (cure with treatment of acute HCV). Adding annual rescreening to the Ryan White Program would facilitate earlier identification of undiagnosed HCV and create an instant widespread surveillance system, providing HCV incidence data.
Asunto(s)
Alanina Transaminasa/sangre , Infecciones por VIH/complicaciones , Hepacivirus/aislamiento & purificación , Hepatitis C/diagnóstico , Adolescente , Adulto , Instituciones de Atención Ambulatoria , Recuento de Linfocito CD4 , Femenino , Infecciones por VIH/epidemiología , Infecciones por VIH/virología , Conocimientos, Actitudes y Práctica en Salud , Hepacivirus/genética , Hepatitis C/epidemiología , Hepatitis C/virología , Anticuerpos contra la Hepatitis C/genética , Anticuerpos contra la Hepatitis C/uso terapéutico , Homosexualidad Masculina/estadística & datos numéricos , Humanos , Incidencia , Masculino , Tamizaje Masivo/métodos , Persona de Mediana Edad , ARN Viral/genética , ARN Viral/inmunología , Estudios Retrospectivos , Rhode Island/epidemiología , Factores de Riesgo , Conducta Sexual , Encuestas y Cuestionarios , Carga Viral , Adulto JovenRESUMEN
OBJECTIVES: Buprenorphine is associated with enhanced human immunodeficiency virus (HIV) treatment outcomes including increased antiretroviral therapy initiation rates, adherence, and CD4 cell counts among HIV-infected opioid-dependent individuals. Buprenorphine facilitates hepatitis C virus (HCV) treatment in opioid-dependent patients with HCV monoinfection. Less is known about buprenorphine's role in HIV/HCV coinfection. METHODS: We conducted a retrospective chart review to evaluate HCV care for HIV-infected buprenorphine patients in the first 4 years of buprenorphine's integration into a Rhode Island HIV clinic. RESULTS: Sixty-one patients initiated buprenorphine. All had HCV antibody testing; 57 (93%) were antibody-positive. All antibody-positive patients underwent HCV RNA testing; 48 (84%) were RNA-positive. Of these, 15 (31%) were not referred to HCV care. Among chronically infected patients, 3 received HCV treatment after buprenorphine; all had cirrhosis and none achieved viral eradication. At buprenorphine induction, most patients had inadequately controlled HIV infection, with detectable HIV RNA (59%) or CD4 cell count less than or equal to 350/µL (38%). CONCLUSIONS: Buprenorphine has shown limited success to date as a bridge to HCV treatment within an HIV clinic. Buprenorphine's stabilization of opioid dependence and HIV disease may permit the use of HCV therapy over time.
Asunto(s)
Antivirales/uso terapéutico , Buprenorfina/uso terapéutico , Infecciones por VIH/epidemiología , Infecciones por VIH/rehabilitación , Hepatitis C Crónica/epidemiología , Hepatitis C Crónica/rehabilitación , Naloxona/uso terapéutico , Narcóticos/uso terapéutico , Tratamiento de Sustitución de Opiáceos , Trastornos Relacionados con Opioides/epidemiología , Trastornos Relacionados con Opioides/rehabilitación , Adulto , Terapia Antirretroviral Altamente Activa , Antivirales/efectos adversos , Buprenorfina/efectos adversos , Combinación Buprenorfina y Naloxona , Comorbilidad , Relación Dosis-Respuesta a Droga , Esquema de Medicación , Combinación de Medicamentos , Humanos , Masculino , Persona de Mediana Edad , Naloxona/efectos adversos , Narcóticos/efectos adversos , Estudios Retrospectivos , Síndrome de Abstinencia a Sustancias/prevención & controlRESUMEN
BACKGROUND: A minority of HIV/HCV coinfected patients with opiate addiction undergo HCV treatment. HCV therapy for HCV-monoinfected methadone maintenance (MM) recipients is safe and effective. We evaluated treatment efficacy and adherence to pegylated interferon (pegIFN) among HIV/HCV coinfected MM recipients. METHODS: HCV treatment-naïve, HIV-infected persons 18-65 years with chronic HCV genotype 1 on MM were prospectively enrolled in an HCV treatment study at two HIV clinics. At weekly visits pegIFN alfa-2a injections were directly administered. Daily MM recipients had morning ribavirin delivered with methadone at off-site methadone clinics. Weekly take-home MM recipients took ribavirin unsupervised. Target enrollment was 30 participants. RESULTS: During 18 recruitment months, 11 participants were enrolled, 6 of whom received daily methadone. Mean age was 46, 64% were female, 5 were Caucasian, 4 Black and 2 Hispanic. At baseline, 82% had high HCV RNA and 55% had stage 2 fibrosis or greater. The majority (91%) were on HAART, and 82% had undetectable HIV RNA with a median CD4(+) of 508cells/µL. All had polysubstance use history, non-substance-based psychiatric diagnoses and were on psychotropic medications pre-enrollment. Two (18%) participants achieved a Sustained Virologic Response (SVR). Two completed 48 treatment weeks, 5 were withdrawn due to adverse events, 2 dropped out prematurely and 2 had treatment discontinued for virologic non-response. Of on-treatment weeks, adherence to pegIFN was >99%. CONCLUSIONS: SVR rate was comparable to historic controls for coinfected genotype 1 patients, with optimal pegIFN adherence. Adverse effects often prevented therapy completion in this population.