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Clin Investig Arterioscler ; 36(4): 210-217, 2024.
Artículo en Inglés, Español | MEDLINE | ID: mdl-38216380

RESUMEN

BACKGROUND: Atherosclerosis is an inflammatory disease. Interleukin 18 (IL-18) is an inflammatory molecule that has been linked to the development of atherosclerosis and cardiovascular disease. OBJECTIVE: To evaluate the possible relationship between plasma levels of IL-18 and the presence of atherosclerosis evaluated at the carotid level, as well as to analyze the possible modulation by different polymorphisms in a Mediterranean population. MATERIAL AND METHODS: Seven hundred and forty-six individuals from the metropolitan area of Valencia were included, recruited over a period of 2 years. Hydrocarbon and lipid metabolism parameters were determined using standard methodology and IL-18 using ELISA. In addition, carotid ultrasound was performed and the genotype of four SNPs related to the IL-18 signaling pathway was analyzed. RESULTS: Patients with higher plasma levels of IL-18 had other associated cardiovascular risk factors. Elevated IL-18 levels were significantly associated with higher carotid IMT and the presence of atheromatous plaques. The genotype with the A allele of the SNP rs2287037 was associated with a higher prevalence of carotid atheromatous plaque. On the contrary, the genotype with the C allele of the SNP rs2293224 was associated with a lower prevalence of atheromatous plaque. CONCLUSIONS: High levels of IL-18 were significantly associated with a higher carotid IMT and the presence of atheromatous plaques, which appear to be influenced by genetic factors, as evidenced by associations between SNPs in the IL-18 receptor gene and the presence of atheroma plaque.


Asunto(s)
Enfermedades de las Arterias Carótidas , Grosor Intima-Media Carotídeo , Genotipo , Interleucina-18 , Placa Aterosclerótica , Polimorfismo de Nucleótido Simple , Anciano , Femenino , Humanos , Masculino , Persona de Mediana Edad , Alelos , Aterosclerosis/genética , Enfermedades de las Arterias Carótidas/genética , Ensayo de Inmunoadsorción Enzimática , Factores de Riesgo de Enfermedad Cardiaca , Interleucina-18/genética , Placa Aterosclerótica/genética , Receptores de Interleucina-18/genética , Factores de Riesgo , España
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