Validity and clinical applicability of the 60-second sit-to-stand test in people with acute exacerbations of COPD.

BACKGROUND: The 60-s sit-to-stand test (60STS) is a simple and increasingly popular test of physical function, however evidence to support its appropriateness for assessing people with acute exacerbations of chronic obstructive pulmonary disease (AECOPD) is lacking. AIMS: To evaluate the concurrent, convergent, predictive and discriminant validity, and responsiveness of the 60STS against the 6-min walk test (6MWT) in people hospitalised due to AECOPD. METHODS: Prospective cohort study involving 54 inpatients with AECOPD (53% males, mean age 69.0 years, FEV1 46.5% predicted). 60STS was performed 30 min after a 6-min walk test (6MWT) upon discharge, with follow-up testing repeated one-month later (n = 39). Outcome measures included 60STS repetitions (60STSr), 6-min walk distance (6MWD), heart rate, oxyhaemoglobin saturation (SpO2), perceived dyspnoea (Borg scale), and rate of perceived exertion (RPE). Concurrent validity was assessed via correlation, convergent validity via Bland-Altman plots, predictive validity via multivariate linear regression (adjusted for confounders), discriminant validity via unpaired t tests and responsiveness via χ2 tests. RESULTS: Discharge 60STSr and 6MWD were strongly correlated (r = 0.61). Bland-Altman plots for nadir SpO2, peak HR, Borg and RPE scores showed acceptable agreement in terms of mean differences, but wide limits of agreement. Poor 60STSr performers were older, had weaker quadriceps, and had lower 6MWD than high performers (p < 0.05 for all). 60STSr was not retained as a significant predictor of 6MWD in multivariate regression analyses. 80% of 60STSr improvers also improved >30 m on 6MWT at follow-up. CONCLUSION: The 60STS demonstrates satisfactory validity and responsiveness as a measure of exercise performance in people with AECOPD.

Prevalence and correlates of sexual risk behaviors among Jamaican adolescents.

CONTEXT: Despite high levels of sexual activity and risk behaviors among Jamaican youth, few population-based studies have examined their prevalence or correlates. METHODS: The prevalence of three sexual risk behaviors was assessed using data from the 2008-2009 Jamaican ?Reproductive Health Survey on a subsample of adolescents aged 15-19 who neither were in a union nor had a child. Factors associated with the risk behaviors were examined separately for females and males, using bivariate analysis and multivariate logistic regression. RESULTS: In the year prior to the survey, 32% of females and 54% of males had had sexual intercourse; of those, 12% and 52%, respectively, had had more than one sexual partner, and 49% and 46% had used condoms ?inconsistently or not at all. School enrollment was protective against females being sexually active and males having multiple partners. Females who were enrolled in an age-appropriate or higher grade had decreased odds of using condoms inconsistently or not at all, and males who were enrolled in a lower than age-appropriate grade had a decreased risk of being sexually active. Males in the lowest wealth tercile were less likely than those in the highest tercile to have been sexually active or to have had multiple partners. Weekly attendance at religious services was protective against all three risk behaviors for both genders, with the exception of inconsistent or no condom use among males. CONCLUSIONS: Future reproductive health programs should continue to target adolescents in venues other than schools and churches, and should also address the varying needs of females and males.

One versus multiple packs for women starting oral contraceptive pills: a comparison of two distribution regimens.

BACKGROUND: Despite World Health Organization and International Planned Parenthood Federation recommendations to provide multiple pill cycles to new users, many programs in developing countries still give only one pill cycle to new acceptors. STUDY DESIGN: To compare provision of a single versus multiple packs of pills, new pill users in 20 matched public sector clinics in Jamaica were assigned to one of two pill regimens in which they received either one (then subsequently three) or four pill cycles at method initiation. The primary outcome was the proportion of women who used pills beyond 4 months. RESULTS: Among 655 women, those receiving one cycle of pills at initiation, followed by counseling and a three-pack resupply, were no more likely to be using pills after 4 months than women who received four packs at initiation (odds ratio=1.33; 95% confidence interval=0.88-2.0). In both pill regimen groups, returning late to the clinic for resupply was a problem. However, more women in the 1+3-pack regimen group returned late to study clinics to obtain their fifth cycle of pills than their counterparts in the 4-pack regimen group (53% vs. 28%). CONCLUSION: Our findings support the recommendation that pill users should be given more than one cycle to start, because an extra visit for resupply contributes to clinic and provider costs. Moreover, providing more pill cycles at initiation would decrease the likelihood that women experience a gap in pill use between cycles.