RESUMEN
Antistaphylococcal penicillins such as nafcillin and oxacillin are among the first choices of treatment for severe invasive methicillin-susceptible Staphylococcus aureus (MSSA) infections, although there has been limited safety evaluations between individual agents. Using the FDA Adverse Event Reports System (FAERS), oxacillin was observed to have a lower proportion of reports of acute renal failure (reporting odds ratio [ROR], 5.3 [95% confidence interval {CI}, 3.1 to 9.3] versus 21.3 [95% CI, 15.8 to 28.6], respectively) and hypokalemia (ROR, 0.7 [95% CI, 0.1 to 4.8] versus 11.4 [95% CI, 7.1 to 18.3], respectively) than nafcillin.
Asunto(s)
Lesión Renal Aguda/inducido químicamente , Antibacterianos/efectos adversos , Hipopotasemia/inducido químicamente , Nafcilina/efectos adversos , Oxacilina/efectos adversos , Infecciones Estafilocócicas/tratamiento farmacológico , Lesión Renal Aguda/diagnóstico , Lesión Renal Aguda/patología , Sistemas de Registro de Reacción Adversa a Medicamentos/estadística & datos numéricos , Antibacterianos/administración & dosificación , Humanos , Hipopotasemia/diagnóstico , Hipopotasemia/patología , Nafcilina/administración & dosificación , Oportunidad Relativa , Oxacilina/administración & dosificación , Seguridad del Paciente , Infecciones Estafilocócicas/microbiología , Infecciones Estafilocócicas/patología , Staphylococcus aureus/efectos de los fármacos , Staphylococcus aureus/crecimiento & desarrollo , Staphylococcus aureus/patogenicidad , Estados Unidos , United States Food and Drug AdministrationRESUMEN
Existing stereoselective routes to 2,5-cyclohexadienones involve either desymmetrization of an achiral substrate or have attempted to perform an asymmetric dearomatization of a phenol. Herein, we report proof-of-principle experiments aimed at developing a kinetic resolution as an alternative method for accessing enantioenriched 2,5-cyclohexadienones. More specifically, chiral bifunctional thiourea catalysts were used to promote the addition of 2-thionapthalene into unsymmetric para-quinols. The selectivity of the kinetic resolution was found to be quite sensitive to substitution around the substrate.