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We address the electron-spin-phonon coupling in an effective model Hamiltonian for DNA to assess its role in spin transfer involved in the Chiral-Induced Spin Selectivity (CISS) effect. The envelope function approach is used to describe semiclassical electron transfer in a tight-binding model of DNA at half filling in the presence of intrinsic spin-orbit coupling. Spin-phonon coupling arises from the orbital-configuration dependence of the spin-orbit interaction. We find spin-phonon coupling only for the acoustic modes, while the optical modes exhibit electron-phonon interaction without coupling to spin. We derive an effective Hamiltonian whose eigenstates carry spin currents that are protected by spin-inactive stretching optical modes. As optical phonons interact more strongly than acoustic phonons, side buckling and tilting optical base modes will be more strongly associated with decoherence, which allows for the two terminal spin filtering effects found in CISS.
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ADN , Fonones , Transporte de Electrón , ElectronesRESUMEN
BACKGROUND: Women bodybuilders build their ideal physique by manipulating their diet, supplement, and exercise regimens to extreme levels. Excess protein intake and dietary supplement use is ubiquitous in women bodybuilders preparing for a competition, i.e., in-season competitors, however the impetus for these two dietary behaviors are relatively unknown. The Theory of Planned Behavior (TPB) has been used to explain dietary behaviors. The purpose of the study was to examine how the TPB can explain protein intake and dietary supplement use in in-season competitors. METHODS: Using a cross-sectional design, an online questionnaire was developed, validated, and administered to collect dietary supplement use, TPB variables, and other measures from 112 in-season competitors. Protein intake was assessed using multiple 24-h dietary recalls. Associations between TPB and protein intake and dietary supplement use were determined with multiple regression analysis while adjusting for confounders. RESULTS: For protein intake: attitude, subjective norm, and perceived behavioral control explained 8% of the variance in intention; subjective norm independently predicted intention. Behavioral beliefs predicted attitude; subjective norm was predicted by trainer/coach, workout partners, and social media influencers. For dietary supplement use: intention explained 5% of the variance in dietary supplement use; attitude, subjective norm, and perceived behavioral control together explained 38% of the variance in intention. Attitudes towards dietary supplements use were predicted by five factors (not a waste of money, help improve physique, sustain energy levels, provide enough calories, help with recovery). Primary determinants of subjective norm were fellow competitors, social media influencers, and trainer/coach. Perceived behavioral control was predicted by three factors (ease of purchase, affordability to purchase, availability to purchase). CONCLUSIONS: TPB predicted dietary supplement use in women bodybuilders during in-season but there was little evidence for the prediction of protein intake using the TPB. Health professionals should develop effective interventions using strategies that align health education messages with in-season competitors' outcome beliefs and collaborate with their referent others to influence safer and effective dietary supplement use.
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Control de la Conducta , Teoría del Comportamiento Planificado , Femenino , Humanos , Estudios Transversales , Suplementos Dietéticos , IntenciónRESUMEN
A joint probability formalism for quantum games with noise is proposed, inspired by the formalism of non-factorizable probabilities that connects the joint probabilities to quantum games with noise. Using this connection, we show that the joint probabilities are non-factorizable; thus, noise does not generically destroy entanglement. This formalism was applied to the Prisoner's Dilemma, the Chicken Game, and the Battle of the Sexes, where noise is coupled through a single parameter µ. We find that for all the games except for the Battle of the Sexes, the Nash inequalities are maintained up to a threshold value of the noise. Beyond the threshold value, the inequalities no longer hold for quantum and classical strategies. For the Battle of the sexes, the Nash inequalities always hold, no matter the noise strength. This is due to the symmetry and anti-symmetry of the parameters that determine the joint probabilities for that game. Finally, we propose a new correlation measure for the games with classical and quantum strategies, where we obtain that the incorporation of noise, when we have quantum strategies, does not affect entanglement, but classical strategies result in behavior that approximates quantum games with quantum strategies without the need to saturate the system with the maximum value of noise. In this manner, these correlations can be understood as entanglement for our game approach.
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Desórdenes Civiles , Política , Investigadores , Ciencia , Justicia Social , Animales , Conflictos Armados , Bolivia , Chile , Desórdenes Civiles/economía , Ecuador , Hong Kong , Humanos , Irán , Líbano , Ciencia/economía , España , Sudán , Siria , Incertidumbre , Universidades , VenezuelaRESUMEN
We analyze the influence of electron-phonon (e-ph) interaction in a model for electron transfer (ET) processes in DNA in terms of the envelope function approach for spinless electrons. We are specifically concerned with the effect of e-ph interaction on the coherence of the ET process and how to model the interaction of DNA with phonon reservoirs of biological relevance. We assume that the electron bearing orbitals are half filled and derive the physics of e-ph coupling in the vicinity in reciprocal space. We find that at half filling, the acoustical modes are decoupled to ET at first order, while optical modes are predominant. The latter are associated with inter-strand vibrational modes in consistency with previous studies involving polaron models of ET. Coupling to acoustic modes depends on electron doping of DNA, while optical modes are always coupled within our model. Our results yield e-ph coupling consistent with estimates in the literature, and we conclude that large polarons are the main result of such e-ph interactions. This scenario will have strong consequences on decoherence of ET under physiological conditions due to relative isolation from thermal equilibration of the ET mechanism.
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ADN/química , Electrones , Modelos Moleculares , Transporte de ElectrónRESUMEN
The coronavirus infectious disease (COVID-19) pandemic emerged at the end of 2019, and was caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), which has resulted in an unprecedented health and economic crisis worldwide. One key aspect, compared to other recent pandemics, is the level of urgency, which has started a race for finding adequate answers. Solutions for efficient prevention approaches, rapid, reliable, and high throughput diagnostics, monitoring, and safe therapies are needed. Research across the world has been directed to fight against COVID-19. Biomedical science has been presented as a possible area for combating the SARS-CoV-2 virus due to the unique challenges raised by the pandemic, as reported by epidemiologists, immunologists, and medical doctors, including COVID-19's survival, symptoms, protein surface composition, and infection mechanisms. While the current knowledge about the SARS-CoV-2 virus is still limited, various (old and new) biomedical approaches have been developed and tested. Here, we review the current status and future perspectives of biomedical science in the context of COVID-19, including nanotechnology, prevention through vaccine engineering, diagnostic, monitoring, and therapy. This review is aimed at discussing the current impact of biomedical science in healthcare for the management of COVID-19, as well as some challenges to be addressed.
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Betacoronavirus/aislamiento & purificación , Investigación Biomédica/normas , Infecciones por Coronavirus/prevención & control , Pandemias/prevención & control , Neumonía Viral/prevención & control , Betacoronavirus/efectos de los fármacos , COVID-19 , Infecciones por Coronavirus/diagnóstico , Infecciones por Coronavirus/transmisión , Infecciones por Coronavirus/virología , Manejo de la Enfermedad , Humanos , Neumonía Viral/diagnóstico , Neumonía Viral/transmisión , Neumonía Viral/virología , SARS-CoV-2RESUMEN
We consider molecular straining as a probe to understand the mobility and spin active features of complex molecules. The strength of the spin-orbit interaction relevant to transport in a low dimensional structure depends critically on the relative geometrical arrangement of current-carrying orbitals. Understanding the origin of the enhanced spin-orbit interaction in chiral systems is crucial to be able to control the spin selectivity observed in the experiments, which is a hallmark of the Chiral-Induced Selectivity Effect (CISS). Recent tight-binding orbital models for spin transport in DNA-like molecules, have surmised that the band spin-orbit (SO) coupling arises from the particular angular relations between orbitals of neighboring bases on the helical chain. Such arrangements could be probed by straining the molecule in a conductive probe AFM/Break junction type setup, as was recently reported by Kiran, Cohen and Naaman. Here we report strain-dependent kinetic and SO coupling when a double-strand DNA model is compressed or stretched in two experimentally feasible setups with peculiar deformation properties. We find that the mobility and the SO coupling can be tuned appreciably by strain, and the analytical model bears out the qualitative trends of the experiments.
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ADN/química , Conformación de Ácido Nucleico , RotaciónRESUMEN
The electronic spin filtering capability of a single chiral helical peptide is measured. A ferromagnetic electrode source is employed to inject spin-polarized electrons in an asymmetric single-molecule junction bridging an α-helical peptide sequence of known chirality. The conductance comparison between both isomers allows the direct determination of the polarization power of an individual chiral molecule.
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Péptidos/química , Marcadores de Spin , Secuencia de Aminoácidos , Conductividad Eléctrica , Electrodos , Electrones , Oro/química , Níquel/química , EstereoisomerismoRESUMEN
A minimal model is exactly solved for electron spin transport on a helix. Electron transport is assumed to be supported by well oriented p(z) type orbitals on base molecules forming a staircase of definite chirality. In a tight binding interpretation, the spin-orbit coupling (SOC) opens up an effective π(z) - π(z) coupling via interbase p(x,y) - p(z) hopping, introducing spin coupled transport. The resulting continuum model spectrum shows two Kramers doublet transport channels with a gap proportional to the SOC. Each doubly degenerate channel satisfies time reversal symmetry; nevertheless, a bias chooses a transport direction and thus selects for spin orientation. The model predicts (i) which spin orientation is selected depending on chirality and bias, (ii) changes in spin preference as a function of input Fermi level and (iii) back-scattering suppression protected by the SO gap. We compute the spin current with a definite helicity and find it to be proportional to the torsion of the chiral structure and the non-adiabatic Aharonov-Anandan phase. To describe room temperature transport, we assume that the total transmission is the result of a product of coherent steps.
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OBJECTIVE: This study describes the frequency of obstetric anal sphincter injuries (OASIS) in patients after instrumental delivery according to the type of forceps used. METHODS: A retrospective comparative cohort study was conducted on patients who underwent instrumental delivery from January 2017 to April 2022. The primary outcome was the presence of OASIS following delivery. Patients were categorized into Cohort A if only rotation forceps were used, Cohort B for only traction forceps, and Cohort C if both types were used sequentially. Statistical analysis was performed with SPSS (IBM, New York, NY) with χ2, Fisher's exact, and analysis of variance testing. A P-value <0.05 was considered significant. RESULTS: OASIS occurred in 45 of 328 instrumental deliveries. OASIS after rotation forceps occurred in 12.9% (n = 8) of cases, after traction forceps in 13.2% (n = 34), and after sequential use of rotation and traction forceps in 37.5% (n = 3) of cases (p = 0.141). An odds ratio (OR) of 0.91 (95% confidence interval [CI] 0.40-2.08) for OASIS was obtained with the use of rotation forceps, 0.81 (95% CI 0.38-1.70) for traction forceps, and 3.97 (95% CI 0.91-17.2) for the sequential use of rotation and traction forceps. CONCLUSION: There were no significant differences in the presence of OASIS comparing traction and rotation forceps. A non-significant trend of higher OASIS following the sequential use of traction and rotation forceps was observed.
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(1) Background: Women bodybuilders use extreme diets, dietary supplementation, and training regimes to sculpt their physiques. Women's participation in bodybuilding competitions has increased since the 1980s. Currently, studies on their dietary intake and supplement use are limited. Their dietary intake may be of poor quality and low in several micronutrients, while supplement use appears to be omnipresent. Thus, the aim of this study was to examine and compare the dietary intake, supplement use, and diet quality of in-season and off-season women bodybuilders. (2) Methods: In a cross-sectional design, we compared dietary intake, supplement use, and diet quality between seasons in women bodybuilders (n = 227). An online questionnaire was developed, validated, and administered to assess all non-dietary and supplement variables. The Automated Self-Administered 24 h Dietary Assessment Tool was used to collect four 24 h dietary recalls. The Healthy Eating Index-2015 (HEI-2015) was used to calculate diet quality. The analysis of covariance and Welch's t-tests were used to assess the differences between in-season and off-season women bodybuilders' dietary intake, supplement, and HEI-2015 variables. (3) Results: In-season competitors reported consuming significantly less energy, carbohydrates, and fat but more protein than off-season competitors. All competitors consumed excess protein, while in-season competitors consumed excess fat and off-season competitors consumed less energy than the physique athlete nutrition recommendations. All competitors' micronutrient intakes were above the Dietary Reference Intakes. Supplements were used by all competitors, and the mean number used was similar between seasons. The HEI-2015 scores were not significantly different between seasons yet were below the US Dietary Guidelines for Americans. (4) Conclusion: Women bodybuilders would benefit from health education to achieve physique athlete nutrition recommendations, improve diet quality, and safe/efficacious supplement use to reach physique goals and improve overall health.
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Classical games get fundamentally modified in the quantum realm because of non-locality and entanglement, that bypass some of the crucial features of the classical problem that define a dilemma. We will analyze how the dilemma can be shunted and even completely eliminated by the players using quantum strategies from the viewpoint of joint probabilities. In this approach, the game information (entropy) needs to be incorporated into the game strategies. We also connect the potential of the formalism of quantum games with the transmission of quantum information in quantum noisy channels and recent considerations of the connection between thermalization mechanisms in statistical mechanics, the many body problem and cooperative games considered here in the quantum regime.
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The spin activity in macromolecules such as DNA and oligopeptides, in the context of the chiral induced spin selectivity has been proposed to be due to the atomic spin-orbit coupling (SOC) and the associated chiral symmetry of the structures. This coupling, associated with carbon, nitrogen and oxygen atoms in biological molecules, albeit small (meV), can be enhanced by the geometry, and strong local polarization effects such as hydrogen bonding. A novel way to manipulate the spin degree of freedom is by modifying the spectrum using a coupling to the appropriate electromagnetic radiation field. Here we use the Floquet formalism in order to show how the half filled band Hamiltonian for DNA, can be modulated by the radiation to produce up to a tenfold increase of the effective SOC once the intrinsic coupling is present. On the other hand, the chiral model, once incorporating the orbital angular momentum of electron motion on the helix, opens a gap for different helicity states (helicity splitting) that chooses spin polarization according to transport direction and chirality, without breaking time reversal symmetry. The observed effects are feasible in physically reasonable parameter ranges for the radiation field amplitude and frequency.
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ADN , Electrones , ADN/química , Enlace de Hidrógeno , Movimiento (Física) , Oligopéptidos/químicaRESUMEN
The development of sustainable, cost-efficient, and high-performance nanofluids is one of the current research topics within drilling applications. The inclusion of tailorable nanoparticles offers the possibility of formulating water-based fluids with enhanced properties, providing unprecedented opportunities in the energy, oil, gas, water, or infrastructure industries. In this work, the most recent and relevant findings related with the development of customizable nanofluids are discussed, focusing on those based on the incorporation of 2D (two-dimensional) nanoparticles and environmentally friendly precursors. The advantages and drawbacks of using 2D layered nanomaterials including but not limited to silicon nano-glass flakes, graphene, MoS2, disk-shaped Laponite nanoparticles, layered magnesium aluminum silicate nanoparticles, and nanolayered organo-montmorillonite are presented. The current formulation approaches are listed, as well as their physicochemical characterization: rheology, viscoelastic properties, and filtration properties (fluid losses). The most influential factors affecting the drilling fluid performance, such as the pH, temperature, ionic strength interaction, and pressure, are also debated. Finally, an overview about the simulation at the microscale of fluids flux in porous media is presented, aiming to illustrate the approaches that could be taken to supplement the experimental efforts to research the performance of drilling muds. The information discussed shows that the addition of 2D nanolayered structures to drilling fluids promotes a substantial improvement in the rheological, viscoelastic, and filtration properties, additionally contributing to cuttings removal, and wellbore stability and strengthening. This also offers a unique opportunity to modulate and improve the thermal and lubrication properties of the fluids, which is highly appealing during drilling operations.
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There is increasing interest in the study of chiral degrees of freedom occurring in matter and in electromagnetic fields. Opportunities in quantum sciences will likely exploit two main areas that are the focus of this Review: (1) recent observations of the chiral-induced spin selectivity (CISS) effect in chiral molecules and engineered nanomaterials and (2) rapidly evolving nanophotonic strategies designed to amplify chiral light-matter interactions. On the one hand, the CISS effect underpins the observation that charge transport through nanoscopic chiral structures favors a particular electronic spin orientation, resulting in large room-temperature spin polarizations. Observations of the CISS effect suggest opportunities for spin control and for the design and fabrication of room-temperature quantum devices from the bottom up, with atomic-scale precision and molecular modularity. On the other hand, chiral-optical effects that depend on both spin- and orbital-angular momentum of photons could offer key advantages in all-optical and quantum information technologies. In particular, amplification of these chiral light-matter interactions using rationally designed plasmonic and dielectric nanomaterials provide approaches to manipulate light intensity, polarization, and phase in confined nanoscale geometries. Any technology that relies on optimal charge transport, or optical control and readout, including quantum devices for logic, sensing, and storage, may benefit from chiral quantum properties. These properties can be theoretically and experimentally investigated from a quantum information perspective, which has not yet been fully developed. There are uncharted implications for the quantum sciences once chiral couplings can be engineered to control the storage, transduction, and manipulation of quantum information. This forward-looking Review provides a survey of the experimental and theoretical fundamentals of chiral-influenced quantum effects and presents a vision for their possible future roles in enabling room-temperature quantum technologies.
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The chiral-induced spin selectivity (CISS) effect, which describes the spin-filtering ability of diamagnetic structures like DNA or peptides having chiral symmetry, has emerged in the past years as the central mechanism behind a number of important phenomena, like long-range biological electron transfer, enantiospecific electrocatalysis, and molecular recognition. Also, CISS-induced spin polarization has a considerable promise for new spintronic devices and the design of quantum materials. The CISS effect is attributed to spin-orbit coupling, but a sound theoretical understanding of the surprising magnitude of this effect in molecules without heavy atoms is currently lacking. We are taking an essential step into this direction by analyzing the importance of imaginary terms in the Hamiltonian as a necessary condition for nonvanishing spin polarization in helical structures. On the basis of first-principles calculations and analytical considerations, we perform a symmetry analysis of the key quantities determining transport probabilities of electrons of different spin orientations. These imaginary terms originate from the spin-orbit coupling, and they preserve the Hermitian nature of the Hamiltonian. Hence, they are not related to the breaking of time-reversal symmetry resulting from the fact that molecules are open systems in a junction. Our symmetry analysis helps to identify essential constraints in the theoretical description of the CISS effect. We further draw an analogy with the appearance of imaginary terms in simple models of barrier scattering, which may help understanding the unusually effective long-range electron transfer in biological systems.
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ADN/química , Teoría Funcional de la Densidad , Péptidos/química , Transporte de Electrón , Electrones , Oro/químicaRESUMEN
We present a model for the transmission of spin-polarized electrons through oriented chiral molecules, where the chiral structure is represented by a helix. The scattering potential contains a confining term and a spin-orbit contribution that is responsible for the spin-dependent scattering of electrons by the molecular target. The differential scattering cross section is calculated for right- and left-handed helices and for arbitrary electron spin polarizations. We apply our model to explain chiral effects in the intensity of photoemitted polarized electrons transmitted through thin organic layers. These are molecular interfaces that exhibit spin-selective scattering with surprisingly large asymmetry factors as well as a number of remarkable magnetic properties. In our model, differences in intensity are generated by the preferential transmission of electron beams whose polarization is oriented in the same direction as the sense of advance of the helix. This model can be easily extended to the Landauer regime of conductance where conductance is due to elastic scattering, so that we can consider the conductance of chiral molecular junctions.
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We address hysteresis of three-dimensional polydisperse granular packs, comparing macro- and microscopic viewpoints, to reveal their elastic/inelastic mechanics and force network anisotropy. During the uniaxial loading-unloading cycle of an appropriately prepared pack, one can decompose the force network into weak and strong subnetworks. The first stages of loading exhibit arching, where all the fabric displays negative anisotropy. For later stages, the strong (weak) network shows positive (negative) anisotropy. On unloading, the force network progresses to a fabric wide hydrostatic point, where the anisotropies of the weak and strong subnetworks switch signs. During the loading stage, a Mohr circle analysis permits the identification of a well-defined macroscopic internal friction angle, whose value is larger than that of grain-grain interactions. To analyze unloading, a generalized local Coulomb-friction argument predicts a continuously changing friction angle, that vanishes at the hydrostatic point. A suggestive interplay between microscopic friction and fabric structure, at different loding stages, is proposed as the mechanism for the emergence of a macro internal friction angle.
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We study the effect of grain polydispersity on the bulk modulus in noncohesive two-dimensional granular solids. Molecular dynamics simulations in two dimensions are used to describe polydisperse samples that reach a stationary limit after a number of hysteresis cycles. For stationary samples, we obtain that the packing with the highest polydispersity has the lowest bulk modulus. We compute the correlation between normal and tangential forces with grain size using the concept of branch vector or contact length. Classifying the contact lengths and forces by their size compared to the average length and average force, respectively, we find that strong normal and tangential forces are carried by large contact lengths, generally composed of at least one large grain. This behavior is more dominant as polydispersity increases, making force networks more anisotropic and removing the support, from small grains, in the loading direction thus reducing the bulk modulus of the granular pack. Our results for two dimensions describe qualitatively the results of three-dimensional experiments.
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A practical electrophilic bromination procedure for phenols and phenol-ethers was developed under efficient and very mild reaction conditions. A broad scope of arenes was investigated, including the benzimidazole and carbazole core as well as analgesics such as naproxen and paracetamol. The new I(iii)-based brominating reagent PhIOAcBr is operationally easy to prepare by mixing PIDA and AlBr3. Our DFT calculations suggest that this is likely the brominating active species, which is prepared in situ or isolated after centrifugation. Its stability at 4 °C after preparation was confirmed over a period of one month and no significant loss of its reactivity was observed. Additionally, the gram-scale bromination of 2-naphthol proceeds with excellent yields. Even for sterically hindered substrates, a moderately good reactivity is observed.