1.
Bioorg Med Chem Lett
; 19(8): 2299-304, 2009 Apr 15.
Artículo
en Inglés
| MEDLINE
| ID: mdl-19282171
RESUMEN
New structural classes of K(V)1.3 and IK-1 ion channel blockers have been identified based on a virtual high throughput screening approach using a homology model of KcsA. These compounds display inhibitory effects on T-cell and/or keratinocyte proliferation and immunosuppressant activity within a DTH animal model.