RESUMEN
A new diterpenoid alkaloid, named bullatine H (1), along with 10 known diterpenoid alkaloids were isolated from the roots of Aconitum brachypodum Diels (Ranunculaceae). The structure of 1 was elucidated by analysis of its spectroscopic data. It should be noted that compound 1 is the first example with 11, 13-dioxygenated denudatine-type diterpenoid alkaloid isolated from Aconitum brachypodum.
Asunto(s)
Aconitum/química , Alcaloides/aislamiento & purificación , Diterpenos/aislamiento & purificación , Medicamentos Herbarios Chinos/aislamiento & purificación , Raíces de Plantas/química , Alcaloides/química , Diterpenos/química , Medicamentos Herbarios Chinos/química , Estructura Molecular , Resonancia Magnética Nuclear BiomolecularAsunto(s)
Alcaloides/farmacología , Antineoplásicos Fitogénicos/farmacología , Medicamentos Herbarios Chinos/farmacología , Hidroxibutiratos/farmacología , Niacina/análogos & derivados , Tripterygium/química , Alcaloides/química , Alcaloides/aislamiento & purificación , Animales , Antiinflamatorios , Antineoplásicos Fitogénicos/química , Antineoplásicos Fitogénicos/aislamiento & purificación , Proliferación Celular/efectos de los fármacos , Supervivencia Celular/efectos de los fármacos , Ensayos de Selección de Medicamentos Antitumorales , Medicamentos Herbarios Chinos/química , Medicamentos Herbarios Chinos/aislamiento & purificación , Hidroxibutiratos/química , Hidroxibutiratos/aislamiento & purificación , Espectroscopía de Resonancia Magnética , Ratones , Conformación Molecular , Niacina/química , Niacina/aislamiento & purificación , Niacina/farmacología , Células RAW 264.7RESUMEN
Phytochemical investigation of an extract of the rhizome of Curcuma longa L., resulted in the identification of four undescribed bisabolane sesquiterpenoids, namely as bisacurone D-G (1-4). With the aid of comprehensive spectroscopic techniques (NMR, IR, UV, MS), the structures of all isolated compounds were elucidated and subsequently screened for both anti-inflammatory and cytotoxic biological activities, Compounds 1 and 2 showed moderate inhibitory activity toward LPS-induced NO production on RAW 264.7 macrophages.
Asunto(s)
Curcuma/química , Sesquiterpenos Monocíclicos/farmacología , Rizoma/química , Animales , Antiinflamatorios/aislamiento & purificación , Antiinflamatorios/farmacología , Línea Celular Tumoral , China , Ciclohexanoles , Humanos , Ratones , Estructura Molecular , Sesquiterpenos Monocíclicos/aislamiento & purificación , Óxido Nítrico/metabolismo , Fitoquímicos/aislamiento & purificación , Fitoquímicos/farmacología , Extractos Vegetales/química , Células RAW 264.7 , SesquiterpenosRESUMEN
Two new aromatic glycosides, 2-methylphenyl O-ß-d-xylopyranosyl-(1â6)-O-ß-d-glucopyranoside (1) and 2-methylphenyl O-α-arabinofuranosyl-(1â6)-O-ß-glucopyranoside (2), together with eight known compounds were isolated from the roots of Ampelopsis delavayana. Their structures were elucidated on the basis of extensive spectroscopic analysis. Furthermore, the in vitro antibacterial activities of 1 and 2 were investigated using serial twofold dilution in three bacteria including Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus.
Asunto(s)
Ampelopsis/química , Antibacterianos/aislamiento & purificación , Glicósidos/aislamiento & purificación , Antibacterianos/química , Escherichia coli/efectos de los fármacos , Glicósidos/química , Glicósidos/farmacología , Estructura Molecular , Raíces de Plantas/química , Pseudomonas aeruginosa/efectos de los fármacos , Staphylococcus aureus/efectos de los fármacosRESUMEN
Two new biphenyls (1 and 2) and three known xanthones (3-5) were isolated from the ethanol extract of the stems of Garcinia tetralata. Structural elucidations of 1-2 were elucidated by spectroscopic methods including extensive 1D- and 2D-nuclear magnetic resonance spectroscopy techniques. Compounds 1-2 showed anti-rotavirus activities with SI above 10.
Asunto(s)
Compuestos de Bifenilo/aislamiento & purificación , Garcinia/química , Extractos Vegetales/química , Antivirales/química , Antivirales/aislamiento & purificación , Antivirales/farmacología , Compuestos de Bifenilo/química , Compuestos de Bifenilo/farmacología , Etanol , Estructura Molecular , Resonancia Magnética Nuclear Biomolecular , Extractos Vegetales/farmacología , Rotavirus/efectos de los fármacos , Xantonas/química , Xantonas/aislamiento & purificaciónRESUMEN
Four ent-kauranoids, 6-epiangustifolin and enanderinanins F-H, as well as 11 known ent-kaurane diterpenoids, macrocalin B, xerophilusin A, trichorabdal A, trichorabdal B, effusin, angustifolin, longikaurin D, longikaurin F, enanderinanin B, xerophilusin G and shikokianin were isolated from the aerial parts of Isodon enanderianus. The new diterpenoids were identified as 6-epiangustifolin (11alpha-hydroxy-6alpha-methoxy-6,19-epoxy-6,7-seco-ent-kaur-16-en-15-one-7,20-olide), enanderinanin F (19-acetoxy-6,20:6,11beta-diepoxy-6,7-seco-ent-kaur-16-en-15-one-1beta,7-olide), enanderinanin G (1beta,6beta,7beta-trihydroxy-19-acetoxy-16beta-methoxymethyl-7alpha,20-epoxy-ent-kaur-15-one) and enanderinanin H (6beta,7beta,14beta-trihydroxy-1alpha,11beta-acetonide-7alpha,20-epoxy-ent-kaur-16-en-15-one), respectively, on the basis of spectral data, especially by 2D NMR techniques. 6-Epiangustifolin showed significant cytotoxic activity against K562 cell.
Asunto(s)
Diterpenos/química , Diterpenos/aislamiento & purificación , Lamiaceae/química , Humanos , Células K562 , Espectroscopía de Resonancia Magnética , Medicina Tradicional China , Estructura MolecularRESUMEN
The isolation from the ethanolic extract of Lagotis yunnanensis of the new compound lagotisoside A (1) and of 10 other constituents is reported.
Asunto(s)
Glicósidos/química , Fitoterapia , Extractos Vegetales/química , Scrophulariaceae , Alcoholes Bencílicos/química , HumanosRESUMEN
OBJECTIVE: To investigate the chemical constituents from the stems of Schisandra sphaerandra. METHOD: Compounds were isolated from ethanolic extract of the titled herb by silica gel column chromatography, and their structures were elucidated by physical and chemical evidences and spectroscopic analysis. RESULT: 12 compounds were obtained and identified as wuweizisu C (1), ganwuweizic acid (2), nigranoic acid (3), catechin (4), 2 alpha,24-dihytroxyursolic acid. (5), 3 beta-O-acetylursolic acid (6), ursolic acid (7), slyceryl 26-hydroxyhexacosanoate (8), slyceryl hexacosanoate (9), fat acids (10), beta-sitosterol (11), daucosterol (12), respectirely. CONCLUSION: Three pentacyclic triterpene carboxylic acid (5-7) were isolated from Schisandreae for the first time.
Asunto(s)
Plantas Medicinales/química , Schisandra/química , Triterpenos/aislamiento & purificación , Tallos de la Planta/química , Triterpenos/química , Ácido UrsólicoRESUMEN
Two new compounds, 5-O-ethylcleroindicin D (1) and bungein A (2), together with 12 known compounds (3-14), were isolated from the aerial parts of the medicinal plant Clerodendrum bungei. The structures of 1 and 2 were elucidated as a perhydrobenzofuran derivative and a peroxide dimer by spectral and chemical evidence. Compounds 3-14 have been obtained from this species for the first time.
Asunto(s)
Clerodendrum , Medicamentos Herbarios Chinos/química , Peróxidos/química , Alcohol Feniletílico/química , Fitoterapia , Aceites de Plantas/química , Terpenos/química , Humanos , Peróxidos/aislamiento & purificación , Alcohol Feniletílico/análogos & derivados , Alcohol Feniletílico/aislamiento & purificación , Terpenos/aislamiento & purificaciónRESUMEN
Two new phenylpropanoid esters of rhamnose, lagotoside B (1) and lagotoside C (2), together with three known compounds (3-5), were isolated from Lagotis yunnanensis. The structures of 1 and 2 were elucidated by spectroscopic methods. Compounds 3-5 have been obtained from this species for the first time.
Asunto(s)
Cinamatos/aislamiento & purificación , Flavonoides/aislamiento & purificación , Ramnosa/aislamiento & purificación , Scrophulariaceae/química , Cinamatos/química , Flavonoides/química , Ramnosa/análogos & derivados , Ramnosa/química , Análisis EspectralRESUMEN
Eight new abietane diterpenoids, coleon U 11-acetate (1), 16-acetoxycoleon U 11-acetate (2), and xanthanthusins F-K (3-8), together with five known analogues, coleon U (9), 16-O-acetylcoleon C (10), coleon U-quinone (11), 8alpha,9alpha-epoxycoleon U-quinone (12), and xanthanthusin E (13), were isolated from the aerial parts of Coleus xanthanthus. The structures of 1-8 were elucidated on the basis of spectral methods. Compounds 1, 5, and 11-13 were evaluated for their cytotoxicity against K562 human leukemia cells.
Asunto(s)
Antineoplásicos Fitogénicos/aislamiento & purificación , Diterpenos/aislamiento & purificación , Medicamentos Herbarios Chinos/química , Lamiaceae/química , Plantas Medicinales/química , Antineoplásicos Fitogénicos/química , Antineoplásicos Fitogénicos/farmacología , Diterpenos/química , Diterpenos/farmacología , Ensayos de Selección de Medicamentos Antitumorales , Humanos , Leucemia , Conformación Molecular , Estructura Molecular , Resonancia Magnética Nuclear Biomolecular , Sales de Tetrazolio , Tiazoles , Células Tumorales Cultivadas/efectos de los fármacosRESUMEN
Four new ent-kaurane diterpenoids, laxiflorins J-M (1-4), along with maoecrystal A (5) and maoecrystal P (6), were isolated from the leaves of Isodon eriocalyx var. laxiflora. Their structures were determined by spectroscopic analyses. All the compounds were assayed for their cytotoxic effects on human tumor K562, A549, and T24 cell lines. Compounds 1 and 6 showed significant inhibitory effects on human tumor K562 and T24 cells, with IC(50) values less than 0.5 microg/mL. Compound 3 also demonstrated cytotoxic activities against all three types of human tumor cells, with IC(50) values in the range of 1-25 microg/mL.
Asunto(s)
Antineoplásicos Fitogénicos/aislamiento & purificación , Diterpenos/aislamiento & purificación , Isodon/química , Plantas Medicinales/química , Antineoplásicos Fitogénicos/química , Antineoplásicos Fitogénicos/farmacología , China , Diterpenos/química , Diterpenos/farmacología , Ensayos de Selección de Medicamentos Antitumorales , Humanos , Concentración 50 Inhibidora , Células K562/efectos de los fármacos , Neoplasias Pulmonares , Conformación Molecular , Estructura Molecular , Resonancia Magnética Nuclear Biomolecular , Hojas de la Planta/química , Estereoisomerismo , Relación Estructura-Actividad , Células Tumorales Cultivadas/efectos de los fármacosRESUMEN
Three new ent-kaurane diterpenoids laxiflorin E (1), laxiflorin H (6) and laxiflorin I (8) were isolated from the leaves of Isodon eriocalyx var. laxiflora, along with nine known diterpenoids, eriocalyxin A (2), laxiflorin C (3), laxiflorin D (4), laxiflorin A (5), maoecrystal S (7), maoecrystal Q (9), eriocalyxin B (10), maoecrystal C (11) and enmelol (12). The structures of the new compounds were determined by spectroscopic methods. Compounds 1-5 are 6,7-seco-ent-kaurane-7,20-olide diterpenoids, and 6-12 belong to 7,20-epoxy-ent-kauranoids. The spectral data of enmelol (12) are reported here for the first time. Ten of these compounds were tested for their cytotoxicity toward K562 and T24 human tumor cells. Compounds 1, 3 and 10 showed significant inhibitory effects on K562 cells with IC50 values 0.077, 0.569 and 0.373 microg/mL, and compounds 1 and 10 also demonstrated significant inhibitory activities toward T24 cells with IC50 values 0.709 and 0.087 microg/mL. Compounds 8 and 11 also displayed inhibitory effect on both two kinds of cells with IC 50 value less than 6.5 microg/mL.