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1.
Clin Microbiol Rev ; 36(3): e0016422, 2023 09 21.
Artículo en Inglés | MEDLINE | ID: mdl-37306571

RESUMEN

Bordetella pertussis and Bordetella bronchiseptica belong to the genus Bordetella, which comprises 14 other species. B. pertussis is responsible for whooping cough in humans, a severe infection in children and less severe or chronic in adults. These infections are restricted to humans and currently increasing worldwide. B. bronchiseptica is involved in diverse respiratory infections in a wide range of mammals. For instance, the canine infectious respiratory disease complex (CIRDC), characterized by a chronic cough in dogs. At the same time, it is increasingly implicated in human infections, while remaining an important pathogen in the veterinary field. Both Bordetella can evade and modulate host immune responses to support their persistence, although it is more pronounced in B. bronchiseptica infection. The protective immune responses elicited by both pathogens are comparable, while there are important characteristics in the mechanisms that differ. However, B. pertussis pathogenesis is more difficult to decipher in animal models than those of B. bronchiseptica because of its restriction to humans. Nevertheless, the licensed vaccines for each Bordetella are different in terms of formulation, route of administration and immune responses induced, with no known cross-reaction between them. Moreover, the target of the mucosal tissues and the induction of long-lasting cellular and humoral responses are required to control and eliminate Bordetella. In addition, the interaction between both veterinary and human fields are essential for the control of this genus, by preventing the infections in animals and the subsequent zoonotic transmission to humans.


Asunto(s)
Infecciones por Bordetella , Bordetella bronchiseptica , Infecciones del Sistema Respiratorio , Vacunas , Tos Ferina , Niño , Animales , Perros , Humanos , Bordetella pertussis/fisiología , Bordetella bronchiseptica/fisiología , Tos Ferina/prevención & control , Infecciones por Bordetella/prevención & control , Mamíferos
2.
Immunohorizons ; 7(11): 788-805, 2023 Nov 01.
Artículo en Inglés | MEDLINE | ID: mdl-38015460

RESUMEN

The oral route is effective and convenient for vaccine administration to stimulate a protective immune response. GALT plays a crucial role in mucosal immune responses, with Peyer's patches (PPs) serving as the primary site of induction. A comprehensive understanding of the structures and functions of these structures is crucial for enhancing vaccination strategies and comprehending disease mechanisms; nonetheless, our current knowledge of these structures in dogs remains incomplete. We performed immunofluorescence and flow cytometry studies on canine PPs to identify cell populations and structures. We also performed single-cell RNA sequencing (scRNA-seq) to investigate the immune cell subpopulations present in PPs at steady state in dogs. We generated and validated an Ab specifically targeting canine M cells, which will be a valuable tool for elucidating Ag trafficking into the GALT of dogs. Our findings will pave the way for future studies of canine mucosal immune responses to oral vaccination and enteropathies. Moreover, they add to the growing body of knowledge in canine immunology, further expanding our understanding of the complex immune system of dogs.


Asunto(s)
Complejo Antígeno-Anticuerpo , Ganglios Linfáticos Agregados , Animales , Perros , Citometría de Flujo , Técnica del Anticuerpo Fluorescente , Análisis de Secuencia de ARN
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